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Aliases for RABAC1 Gene

Aliases for RABAC1 Gene

  • Rab Acceptor 1 2 3 5
  • Rab Acceptor 1 (Prenylated) 2 3
  • Prenylated Rab Acceptor 1 2 3
  • PRA1 Family Protein 1 3 4
  • PRA1 Domain Family 1 2 3
  • PRAF1 3 4
  • PRA1 3 4
  • Prenylated Rab Acceptor Protein 1 3
  • YIP3 3

External Ids for RABAC1 Gene

Previous GeneCards Identifiers for RABAC1 Gene

  • GC19M043100
  • GC19M042852
  • GC19M047136
  • GC19M047152
  • GC19M042460
  • GC19M038891

Summaries for RABAC1 Gene

GeneCards Summary for RABAC1 Gene

RABAC1 (Rab Acceptor 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and proline-rich region binding.

UniProtKB/Swiss-Prot for RABAC1 Gene

  • General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Gene Wiki entry for RABAC1 Gene

Additional gene information for RABAC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABAC1 Gene

Genomics for RABAC1 Gene

GeneHancer (GH) Regulatory Elements for RABAC1 Gene

Promoters and enhancers for RABAC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041957 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 681.6 +0.8 755 2.9 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B RABAC1 ZNF526 HNRNPUL1 CCDC97 ZNF574 RPS19 CYP2G2P CEACAMP1 ENSG00000271299 MEGF8
GH19J041928 Promoter/Enhancer 1.5 Ensembl ENCODE 31.4 +30.4 30421 1.5 HDGF ARNT SIN3A ZNF2 POLR2B ZNF766 E2F8 ZNF143 ZNF263 SP3 LOC390937 LOC100505585 ZNF526 ZNF574 HNRNPUL1 CCDC97 RABAC1 CIC ARHGEF1
GH19J041937 Enhancer 1.4 FANTOM5 Ensembl ENCODE 31.8 +19.7 19670 4.3 HDGF PKNOX1 ZNF133 SIN3A ZNF48 GLIS2 ZNF213 KLF7 RUNX3 SP3 RABAC1 CD79A ARHGEF1 POU2F2 LOC100505585
GH19J041859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.1 +97.4 97381 5.9 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC RPS19 PIR51753 ZNF526 CCDC97 HNRNPUL1 ZNF574 RABAC1 CIC ARHGEF1 MIR6797
GH19J041882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.1 +72.7 72731 9.2 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ARHGEF1 ZNF526 CCDC97 HNRNPUL1 ZNF574 RPS19 RABAC1 ENSG00000271299 CEACAMP1 CYP2G2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RABAC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RABAC1 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • Pax-5
  • GATA-2
  • p300
  • MIF-1
  • SEF-1 (1)
  • TGIF

Genomic Locations for RABAC1 Gene

Genomic Locations for RABAC1 Gene
chr19:41,956,681-41,959,390
(GRCh38/hg38)
Size:
2,710 bases
Orientation:
Minus strand
chr19:42,460,833-42,463,542
(GRCh37/hg19)
Size:
2,710 bases
Orientation:
Minus strand

Genomic View for RABAC1 Gene

Genes around RABAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABAC1 Gene

Proteins for RABAC1 Gene

  • Protein details for RABAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI14-PRAF1_HUMAN
    Recommended name:
    Prenylated Rab acceptor protein 1
    Protein Accession:
    Q9UI14
    Secondary Accessions:
    • Q7Z4Y2
    • Q9Y3R1

    Protein attributes for RABAC1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20648 Da
    Quaternary structure:
    • Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.

neXtProt entry for RABAC1 Gene

Post-translational modifications for RABAC1 Gene

  • Ubiquitination at posLast=118118 and Lys24
  • Modification sites at PhosphoSitePlus

Other Protein References for RABAC1 Gene

No data available for DME Specific Peptides for RABAC1 Gene

Domains & Families for RABAC1 Gene

Gene Families for RABAC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for RABAC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RABAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI14

UniProtKB/Swiss-Prot:

PRAF1_HUMAN :
  • Belongs to the PRA1 family.
Family:
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with RABAC1: view

Function for RABAC1 Gene

Molecular function for RABAC1 Gene

UniProtKB/Swiss-Prot Function:
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Gene Ontology (GO) - Molecular Function for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IEA --
GO:0042802 identical protein binding IPI 16169070
GO:0070064 proline-rich region binding IEA --
genes like me logo Genes that share ontologies with RABAC1: view
genes like me logo Genes that share phenotypes with RABAC1: view

Animal Models for RABAC1 Gene

MGI Knock Outs for RABAC1:
  • Rabac1 Rabac1<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RABAC1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RABAC1 Gene

Localization for RABAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RABAC1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250 UniProtKB:O35394}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RABAC1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
peroxisome 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RABAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with RABAC1: view

Pathways & Interactions for RABAC1 Gene

SuperPathways for RABAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RABAC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RABAC1 Gene

Drugs & Compounds for RABAC1 Gene

No Compound Related Data Available

Transcripts for RABAC1 Gene

mRNA/cDNA for RABAC1 Gene

Unigene Clusters for RABAC1 Gene

Rab acceptor 1 (prenylated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RABAC1

Alternative Splicing Database (ASD) splice patterns (SP) for RABAC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for RABAC1 Gene

GeneLoc Exon Structure for
RABAC1
ECgene alternative splicing isoforms for
RABAC1

Expression for RABAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RABAC1 Gene

Protein differential expression in normal tissues from HIPED for RABAC1 Gene

This gene is overexpressed in Stomach (11.7), Oral epithelium (10.4), and Bone (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RABAC1 Gene



Protein tissue co-expression partners for RABAC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RABAC1 Gene:

RABAC1

SOURCE GeneReport for Unigene cluster for RABAC1 Gene:

Hs.11417

mRNA Expression by UniProt/SwissProt for RABAC1 Gene:

Q9UI14-PRAF1_HUMAN
Tissue specificity: Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.

Evidence on tissue expression from TISSUES for RABAC1 Gene

  • Nervous system(4.7)
  • Kidney(4.5)
  • Pancreas(4.4)
  • Intestine(2.3)
  • Muscle(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RABAC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RABAC1 Gene

Orthologs for RABAC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RABAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABAC1 34 33
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RABAC1 34 33
  • 91.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RABAC1 34 33
  • 90.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rabac1 16 34 33
  • 89.37 (n)
rat
(Rattus norvegicus)
Mammalia Rabac1 33
  • 87.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RABAC1 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABAC1 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabac1 33
  • 67.03 (n)
Str.10823 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23872 33
zebrafish
(Danio rerio)
Actinopterygii rabac1 34 33
  • 62.16 (n)
OneToOne
wufe26d12 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003662 33
  • 52.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1418 34 33
  • 49.25 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIP3 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9753 34
  • 41 (a)
OneToOne
Species where no ortholog for RABAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RABAC1 Gene

ENSEMBL:
Gene Tree for RABAC1 (if available)
TreeFam:
Gene Tree for RABAC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RABAC1: view image

Paralogs for RABAC1 Gene

No data available for Paralogs for RABAC1 Gene

Variants for RABAC1 Gene

Sequence variations from dbSNP and Humsavar for RABAC1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000236989 -- 41,957,790(-) T/G intron_variant
rs1002177196 -- 41,959,159(-) C/G intron_variant
rs1003010239 -- 41,956,247(-) C/G downstream_transcript_variant
rs1003227137 -- 41,960,928(-) C/T upstream_transcript_variant
rs1003584262 -- 41,960,546(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RABAC1 Gene

Variant ID Type Subtype PubMed ID
dgv3550n100 CNV gain 25217958
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv953580 CNV deletion 24416366

Variation tolerance for RABAC1 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RABAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RABAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABAC1 Gene

Disorders for RABAC1 Gene

Additional Disease Information for RABAC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RABAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABAC1 Gene

Publications for RABAC1 Gene

  1. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo CS … Bachmann AS (Gene 2006) 3 4 22 58
  2. Expression analysis and chromosomal assignment of PRA1 and RILP genes. (PMID: 11520070) Bucci C … Bruni CB (Biochemical and biophysical research communications 2001) 3 4 22 58
  3. Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). (PMID: 10329441) Bucci C … Bruni CB (Biochemical and biophysical research communications 1999) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin. (PMID: 16930546) Kim JT … Lim JS (Biochemical and biophysical research communications 2006) 3 22 58

Products for RABAC1 Gene

Sources for RABAC1 Gene

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