Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LRRN2 Gene

Aliases for LRRN2 Gene

  • Leucine Rich Repeat Neuronal 2 2 3 5
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domain 7 2 3
  • Glioma Amplified On Chromosome 1 Protein 3 4
  • Leucine-Rich Repeat Neuronal Protein 5 3 4
  • Leucine Rich And Ankyrin Repeats 1 2 3
  • Leucine Rich Repeat Neuronal 5 2 3
  • LRRN5 3 4
  • GAC1 3 4
  • Leucine-Rich Repeat Neuronal Protein 2 3
  • FIGLER7 3
  • LRANK1 3

External Ids for LRRN2 Gene

Previous HGNC Symbols for LRRN2 Gene

  • LRRN5

Previous GeneCards Identifiers for LRRN2 Gene

  • GC00U911621
  • GC01M202853
  • GC01M175751

Summaries for LRRN2 Gene

Entrez Gene Summary for LRRN2 Gene

  • The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRN2 Gene

LRRN2 (Leucine Rich Repeat Neuronal 2) is a Protein Coding gene. An important paralog of this gene is LRRN1.

Gene Wiki entry for LRRN2 Gene

Additional gene information for LRRN2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRN2 Gene

Genomics for LRRN2 Gene

GeneHancer (GH) Regulatory Elements for LRRN2 Gene

Promoters and enhancers for LRRN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J204685 Promoter 1.1 Ensembl 650.7 +0.5 532 0.4 MXI1 KLF1 LEF1 KLF17 SIN3A RFX5 ZNF335 E2F1 GLIS2 ZBTB48 LRRN2 ENSG00000228153
GH01J204686 Promoter 1.1 EPDnew 650.7 0.0 -20 0.1 KLF17 ZBTB7B YY1 ZNF335 GLIS2 KLF7 EGR2 SP3 YY2 GATAD2B LRRN2 GC01P204706
GH01J204687 Promoter 0.8 EPDnew 650.7 +0.3 283 0.1 E2F1 MXI1 LEF1 SIN3A ZBTB26 ZFX ZBTB17 LRRN2 ENSG00000228153
GH01J204671 Promoter 0.6 EPDnew 650.4 +14.1 14072 0.1 ZNF512 LRRN2 ENSG00000228153
GH01J204684 Enhancer 0.4 FANTOM5 659.1 +1.4 1371 0.3 SCRT1 ZNF341 LRRN2 TMEM81 PLEKHA6 NFASC ENSG00000228153
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRN2 gene promoter:
  • E47
  • Lmo2
  • Hand1
  • HNF-4alpha1
  • GCNF-1
  • GCNF

Genomic Locations for LRRN2 Gene

Genomic Locations for LRRN2 Gene
chr1:204,617,170-204,685,733
(GRCh38/hg38)
Size:
68,564 bases
Orientation:
Minus strand
chr1:204,586,298-204,654,861
(GRCh37/hg19)
Size:
68,564 bases
Orientation:
Minus strand

Genomic View for LRRN2 Gene

Genes around LRRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRN2 Gene

Proteins for LRRN2 Gene

  • Protein details for LRRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75325-LRRN2_HUMAN
    Recommended name:
    Leucine-rich repeat neuronal protein 2
    Protein Accession:
    O75325
    Secondary Accessions:
    • B2R624
    • Q5T0Y0
    • Q6UXM0
    • Q8N182

    Protein attributes for LRRN2 Gene

    Size:
    713 amino acids
    Molecular mass:
    78859 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRN2 Gene

Post-translational modifications for LRRN2 Gene

  • Glycosylation at posLast=583583, posLast=555555, posLast=381381, and posLast=9494
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRN2 Gene

No data available for DME Specific Peptides for LRRN2 Gene

Domains & Families for LRRN2 Gene

Gene Families for LRRN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LRRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRN2: view

No data available for UniProtKB/Swiss-Prot for LRRN2 Gene

Function for LRRN2 Gene

Phenotypes From GWAS Catalog for LRRN2 Gene

Gene Ontology (GO) - Molecular Function for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0038023 signaling receptor activity TAS 9662332
genes like me logo Genes that share ontologies with LRRN2: view
genes like me logo Genes that share phenotypes with LRRN2: view

Animal Models for LRRN2 Gene

MGI Knock Outs for LRRN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRN2

miRNA for LRRN2 Gene

miRTarBase miRNAs that target LRRN2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRN2 Gene

Localization for LRRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRN2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRN2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRN2: view

Pathways & Interactions for LRRN2 Gene

SuperPathways for LRRN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9662332
GO:0007165 signal transduction TAS 9662332
GO:0007409 axonogenesis IBA --
genes like me logo Genes that share ontologies with LRRN2: view

No data available for Pathways by source and SIGNOR curated interactions for LRRN2 Gene

Drugs & Compounds for LRRN2 Gene

No Compound Related Data Available

Transcripts for LRRN2 Gene

Unigene Clusters for LRRN2 Gene

Leucine rich repeat neuronal 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for LRRN2 Gene

GeneLoc Exon Structure for
LRRN2
ECgene alternative splicing isoforms for
LRRN2

Expression for LRRN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of LRRN2 Gene:

LRRN2

SOURCE GeneReport for Unigene cluster for LRRN2 Gene:

Hs.26312

mRNA Expression by UniProt/SwissProt for LRRN2 Gene:

O75325-LRRN2_HUMAN
Tissue specificity: Overamplified in malignant gliomas.

Evidence on tissue expression from TISSUES for LRRN2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with LRRN2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRN2 Gene

Orthologs for LRRN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRN2 34 33
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRN2 34 33
  • 90.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrn2 16 34 33
  • 87.27 (n)
rat
(Rattus norvegicus)
Mammalia Lrrn2 33
  • 87.08 (n)
cow
(Bos Taurus)
Mammalia LRRN5 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRN2 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRN2 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRN2 34 33
  • 71.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRN2 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100150431 33
  • 60.17 (n)
LRRN2 34
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011378 33
  • 49.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta trn 34 33
  • 44.29 (n)
ManyToMany
caps 34
  • 25 (a)
ManyToMany
CG14762 34
  • 22 (a)
ManyToMany
Fili 34
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lron-11 34
  • 23 (a)
OneToMany
Species where no ortholog for LRRN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LRRN2 Gene

ENSEMBL:
Gene Tree for LRRN2 (if available)
TreeFam:
Gene Tree for LRRN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRN2: view image

Paralogs for LRRN2 Gene

(2) SIMAP similar genes for LRRN2 Gene using alignment to 1 proteins:

  • LRRN2_HUMAN
genes like me logo Genes that share paralogs with LRRN2: view

Variants for LRRN2 Gene

Sequence variations from dbSNP and Humsavar for LRRN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000083764 -- 204,645,798(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000139022 -- 204,672,455(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000241757 -- 204,631,526(-) A/G intron_variant
rs1000259079 -- 204,622,382(-) C/T intron_variant
rs1000435995 -- 204,616,855(-) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRN2 Gene

Variant ID Type Subtype PubMed ID
esv3328620 CNV insertion 20981092
esv3336117 CNV insertion 20981092
esv3588622 CNV gain 21293372
nsv4154 CNV insertion 18451855

Variation tolerance for LRRN2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.36; 94.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRN2 Gene

Disorders for LRRN2 Gene

Additional Disease Information for LRRN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRN2 Gene

Publications for LRRN2 Gene

  1. GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas. (PMID: 9662332) Almeida A … Hanash S (Oncogene 1998) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for LRRN2 Gene

Sources for LRRN2 Gene

Content
Loading form....