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Aliases for TUBGCP3 Gene

Aliases for TUBGCP3 Gene

  • Tubulin Gamma Complex Associated Protein 3 2 3 5
  • Spindle Pole Body Protein Spc98 Homolog 3 4
  • Gamma-Ring Complex Protein 104 KDa 3 4
  • GCP3 3 4
  • Tubulin, Gamma Complex Associated Protein 3 2
  • Gamma-Tubulin Complex Component 3 3
  • Spindle Pole Body Protein 2
  • HGrip104 4
  • Grip104 3
  • SPBC98 3
  • Spc98p 3
  • HSpc98 4
  • Spc98 3
  • GCP-3 4
  • H104p 4
  • HGCP3 4
  • 104p 3
  • ALP6 3

External Ids for TUBGCP3 Gene

Previous GeneCards Identifiers for TUBGCP3 Gene

  • GC13M111749
  • GC13M107776
  • GC13M112225
  • GC13M111087
  • GC13M112187
  • GC13M113139
  • GC13M093580

Summaries for TUBGCP3 Gene

GeneCards Summary for TUBGCP3 Gene

TUBGCP3 (Tubulin Gamma Complex Associated Protein 3) is a Protein Coding gene. Diseases associated with TUBGCP3 include Cardiomyopathy, Dilated, 1P. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include structural molecule activity and gamma-tubulin binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot for TUBGCP3 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP3 Gene

Additional gene information for TUBGCP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP3 Gene

Genomics for TUBGCP3 Gene

GeneHancer (GH) Regulatory Elements for TUBGCP3 Gene

Promoters and enhancers for TUBGCP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J112586 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 691.4 +18.6 18605 2.8 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 E2F8 TUBGCP3 GC13P112588 PCID2 LOC102724489 LINC02337 CUL4A LINC01043 SPACA7 LINC01044 LDHBP1
GH13J112605 Promoter/Enhancer 1.4 Ensembl ENCODE 665.4 +0.2 205 1.7 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 ZNF143 RUNX3 DEK SP3 SP5 TUBGCP3 ENSG00000277159 ATP11AUN ATP11A-AS1 MCF2L GC13P112588
GH13J113206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 102.4 -602.4 -602400 5 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 PCID2 CUL4A TUBGCP3 PROZ GAS6-AS1 GAS6 LINC01043 DCUN1D2-AS SPACA7 LDHBP1
GH13J113296 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.4 -691.3 -691252 2.6 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 LAMP1 CDC16 TUBGCP3 PCID2 UPF3A GAS6-DT GAS6 LINC01043 CUL4A SPACA7
GH13J113583 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 34.9 -978.6 -978606 2.5 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF766 GLIS2 ARID2 ZNF143 ATF7 TFDP1 TUBGCP3 CDC16 PCID2 GRK1 GAS6 LDHBP1 GAS6-AS1 LINC00454 TMCO3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBGCP3 gene promoter:
  • PPAR-alpha
  • En-1
  • YY1
  • GR
  • GR-alpha

Genomic Locations for TUBGCP3 Gene

Genomic Locations for TUBGCP3 Gene
chr13:112,485,005-112,606,442
(GRCh38/hg38)
Size:
121,438 bases
Orientation:
Minus strand
chr13:113,139,325-113,242,481
(GRCh37/hg19)
Size:
103,157 bases
Orientation:
Minus strand

Genomic View for TUBGCP3 Gene

Genes around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP3 Gene

Proteins for TUBGCP3 Gene

  • Protein details for TUBGCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW5-GCP3_HUMAN
    Recommended name:
    Gamma-tubulin complex component 3
    Protein Accession:
    Q96CW5
    Secondary Accessions:
    • O43631
    • O60852
    • O60853
    • Q5T8L2
    • Q7Z4K1
    • Q96I79

    Protein attributes for TUBGCP3 Gene

    Size:
    907 amino acids
    Molecular mass:
    103571 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2. Interacts with NIN (via N-terminus); the interaction may promote recruitment of the gamma-tubulin ring complex to the centrosome (By similarity).

    Alternative splice isoforms for TUBGCP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP3 Gene

Post-translational modifications for TUBGCP3 Gene

  • Ubiquitination at posLast=379379, posLast=303303, posLast=280280, isoforms=2, 3276, and isoforms=2, 3220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBGCP3 Gene

Domains & Families for TUBGCP3 Gene

Gene Families for TUBGCP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBGCP3 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96CW5

UniProtKB/Swiss-Prot:

GCP3_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP3: view

Function for TUBGCP3 Gene

Molecular function for TUBGCP3 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Phenotypes From GWAS Catalog for TUBGCP3 Gene

Gene Ontology (GO) - Molecular Function for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 9566967
GO:0005200 structural constituent of cytoskeleton NAS,IBA 9566969
GO:0005515 protein binding IPI 9566969
GO:0043015 gamma-tubulin binding IDA,IEA 9566969
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view
genes like me logo Genes that share phenotypes with TUBGCP3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP3 Gene

Localization for TUBGCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0000930 gamma-tubulin complex IBA --
GO:0005737 cytoplasm IDA,IEA 9566969
GO:0005813 centrosome NAS 11694571
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUBGCP3 Gene

Pathways & Interactions for TUBGCP3 Gene

genes like me logo Genes that share pathways with TUBGCP3: view

Gene Ontology (GO) - Biological Process for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation NAS,IEA 9566969
GO:0007338 single fertilization NAS 9138452
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
GO:0051321 meiotic cell cycle IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for SIGNOR curated interactions for TUBGCP3 Gene

Drugs & Compounds for TUBGCP3 Gene

(1) Drugs for TUBGCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP3: view

Transcripts for TUBGCP3 Gene

Unigene Clusters for TUBGCP3 Gene

Tubulin, gamma complex associated protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP3 Gene

No ASD Table

Relevant External Links for TUBGCP3 Gene

GeneLoc Exon Structure for
TUBGCP3
ECgene alternative splicing isoforms for
TUBGCP3

Expression for TUBGCP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBGCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBGCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Testis (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBGCP3 Gene



Protein tissue co-expression partners for TUBGCP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP3 Gene:

TUBGCP3

SOURCE GeneReport for Unigene cluster for TUBGCP3 Gene:

Hs.224152

mRNA Expression by UniProt/SwissProt for TUBGCP3 Gene:

Q96CW5-GCP3_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TUBGCP3 Gene

  • Nervous system(4.4)
  • Eye(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TUBGCP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBGCP3 Gene

Orthologs for TUBGCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP3 34 33
  • 99.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBGCP3 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP3 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP3 34 33
  • 86.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tubgcp3 16 34 33
  • 85.08 (n)
cow
(Bos Taurus)
Mammalia TUBGCP3 34 33
  • 81.37 (n)
OneToOne
chicken
(Gallus gallus)
Aves TUBGCP3 34 33
  • 81.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBGCP3 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp3 33
  • 77.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69134 33
zebrafish
(Danio rerio)
Actinopterygii tubgcp3 34 33
  • 71.65 (n)
OneToOne
wufc09h08 33
fruit fly
(Drosophila melanogaster)
Insecta l(1)dd4 34 33
  • 46.57 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003865 33
  • 45.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 36 34
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SPC98 33
  • 48.11 (n)
rice
(Oryza sativa)
Liliopsida Os09g0446200 33
  • 46.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Cin.1647 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1647 33
Species where no ortholog for TUBGCP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP3 Gene

ENSEMBL:
Gene Tree for TUBGCP3 (if available)
TreeFam:
Gene Tree for TUBGCP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUBGCP3: view image

Paralogs for TUBGCP3 Gene

Paralogs for TUBGCP3 Gene

genes like me logo Genes that share paralogs with TUBGCP3: view

Variants for TUBGCP3 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000005414 -- 112,560,237(-) C/T intron_variant
rs1000025970 -- 112,535,281(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000036519 -- 112,559,917(-) T/G intron_variant
rs1000037656 -- 112,601,892(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000040743 -- 112,567,675(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP3 Gene

Variant ID Type Subtype PubMed ID
dgv1122e59 CNV duplication 20981092
dgv1123e59 CNV duplication 20981092
dgv3417n54 CNV gain 21841781
esv1008083 CNV loss 20482838
esv2222613 CNV deletion 18987734
esv23229 CNV loss 19812545
esv2433291 CNV deletion 19546169
esv2748156 CNV deletion 23290073
esv2748157 CNV deletion 23290073
esv2748158 CNV deletion 23290073
esv2748159 CNV deletion 23290073
esv2748160 CNV deletion 23290073
esv3448947 CNV duplication 20981092
esv3580908 CNV loss 25503493
esv3633580 CNV gain 21293372
esv5608 CNV loss 19470904
esv8189 CNV gain 19470904
nsv1044644 CNV gain 25217958
nsv1045238 CNV gain 25217958
nsv1053676 CNV gain 25217958
nsv820877 CNV duplication 20802225

Variation tolerance for TUBGCP3 Gene

Residual Variation Intolerance Score: 4.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBGCP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBGCP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Disorders for TUBGCP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUBGCP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1p
  • cmd1p
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TUBGCP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TUBGCP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBGCP3 Gene

Publications for TUBGCP3 Gene

  1. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy SM … Stearns T (The Journal of cell biology 1998) 2 3 4 22 58
  2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin AM … Bornens M (The Journal of cell biology 1998) 2 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X … Merdes A (Journal of cell science 2009) 3 22 58
  5. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. (PMID: 17959831) Fong KW … Qi RZ (Molecular biology of the cell 2008) 3 4 58

Products for TUBGCP3 Gene

Sources for TUBGCP3 Gene

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