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Aliases for PGRMC2 Gene

Aliases for PGRMC2 Gene

  • Progesterone Receptor Membrane Component 2 2 3 5
  • Steroid Receptor Protein DG6 3 4
  • PMBP 3 4
  • DG6 3 4
  • Membrane-Associated Progesterone Receptor Component 2 3
  • Progesterone Membrane Binding Protein 3
  • Progesterone Membrane-Binding Protein 4

External Ids for PGRMC2 Gene

Previous GeneCards Identifiers for PGRMC2 Gene

  • GC04M130123
  • GC04M129484
  • GC04M129650
  • GC04M129548
  • GC04M129190
  • GC04M124921

Summaries for PGRMC2 Gene

GeneCards Summary for PGRMC2 Gene

PGRMC2 (Progesterone Receptor Membrane Component 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC1.

UniProtKB/Swiss-Prot for PGRMC2 Gene

  • Receptor for steroids.

Additional gene information for PGRMC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC2 Gene

Genomics for PGRMC2 Gene

GeneHancer (GH) Regulatory Elements for PGRMC2 Gene

Promoters and enhancers for PGRMC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J128284 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.9 +1.3 1254 6.3 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PGRMC2 MFSD8 ABHD18 FOSL1P1
GH04J128551 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 20.8 -264.6 -264611 3 PKNOX1 SMAD1 FOXA2 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B LOC101927259 MFSD8 PGRMC2 RPL21P53 ABHD18 INTU JADE1 C4orf33 GC04P128333
GH04J127963 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 +323.6 323585 2.9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 MFSD8 ABHD18 PGRMC2 RNU6-583P
GH04J128383 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -97.4 -97446 5.9 PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 GLIS2 ZNF213 FOS REST TSHZ1 LOC100507487 PGRMC2 GC04P128333 LOC101927259
GH04J128320 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.7 -34.1 -34076 4.2 PKNOX1 RAD21 BRCA1 RFX5 RCOR1 FOS CAVIN1 CEBPB ZEB2 ZNF217 LOC100507487 PGRMC2 GC04P128333
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGRMC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGRMC2 gene promoter:
  • FOXO1a
  • FOXO1
  • TBP
  • E47
  • ZID
  • c-Myb
  • Lmo2
  • FOXD1
  • POU2F1a
  • POU2F1

Genomic Locations for PGRMC2 Gene

Genomic Locations for PGRMC2 Gene
19,593 bases
Minus strand
19,593 bases
Minus strand

Genomic View for PGRMC2 Gene

Genes around PGRMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGRMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGRMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC2 Gene

Proteins for PGRMC2 Gene

  • Protein details for PGRMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-associated progesterone receptor component 2
    Protein Accession:
    Secondary Accessions:
    • Q569H1

    Protein attributes for PGRMC2 Gene

    223 amino acids
    Molecular mass:
    23818 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PGRMC2 Gene


neXtProt entry for PGRMC2 Gene

Post-translational modifications for PGRMC2 Gene

  • Ubiquitination at isoforms=2193, isoforms=2191, isoforms=2135, and Lys126
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PGRMC2 Gene

Domains & Families for PGRMC2 Gene

Gene Families for PGRMC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PGRMC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC2: view

Function for PGRMC2 Gene

Molecular function for PGRMC2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for steroids.

Gene Ontology (GO) - Molecular Function for PGRMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity TAS 9705155
GO:0005496 steroid binding TAS,IEA --
GO:0005515 protein binding IPI 27599036
GO:0008289 lipid binding IEA --
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with PGRMC2: view
genes like me logo Genes that share phenotypes with PGRMC2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC2 Gene

Localization for PGRMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGRMC2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGRMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 25468996
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with PGRMC2: view

Pathways & Interactions for PGRMC2 Gene

SuperPathways for PGRMC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PGRMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043401 steroid hormone mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with PGRMC2: view

No data available for Pathways by source and SIGNOR curated interactions for PGRMC2 Gene

Drugs & Compounds for PGRMC2 Gene

(2) Drugs for PGRMC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator, Agonist, Inhibition, Pore Blocker Endogenous progesterone receptor agonist 600
heme Pharma Agonist 0

(1) Additional Compounds for PGRMC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
genes like me logo Genes that share compounds with PGRMC2: view

Transcripts for PGRMC2 Gene

mRNA/cDNA for PGRMC2 Gene

Unigene Clusters for PGRMC2 Gene

Progesterone receptor membrane component 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for PGRMC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGRMC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGRMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC2 Gene

This gene is overexpressed in Nasal epithelium (12.5), Bone (12.3), and Adipocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PGRMC2 Gene

Protein tissue co-expression partners for PGRMC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGRMC2 Gene:


SOURCE GeneReport for Unigene cluster for PGRMC2 Gene:


Evidence on tissue expression from TISSUES for PGRMC2 Gene

  • Kidney(4.4)
  • Liver(4.4)
  • Nervous system(4)
  • Muscle(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with PGRMC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGRMC2 Gene

Orthologs for PGRMC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGRMC2 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia PGRMC2 34 33
  • 95.67 (n)
(Bos Taurus)
Mammalia PGRMC2 34 33
  • 94.47 (n)
(Ornithorhynchus anatinus)
Mammalia PGRMC2 34
  • 89 (a)
(Mus musculus)
Mammalia Pgrmc2 16 34 33
  • 87.25 (n)
(Rattus norvegicus)
Mammalia Pgrmc2 33
  • 86.02 (n)
(Monodelphis domestica)
Mammalia PGRMC2 34
  • 64 (a)
(Gallus gallus)
Aves PGRMC2 34 33
  • 83.13 (n)
(Anolis carolinensis)
Reptilia PGRMC2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgrmc2 33
  • 75.31 (n)
LOC394928 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33468 33
(Danio rerio)
Actinopterygii pgrmc2 34 33
  • 69.46 (n)
wufb25g12 33
fruit fly
(Drosophila melanogaster)
Insecta CG9066 35
  • 53 (a)
  • 35 (a)
(Caenorhabditis elegans)
Secernentea vem-1 34
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4516 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4516 33
Species where no ortholog for PGRMC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC2 Gene

Gene Tree for PGRMC2 (if available)
Gene Tree for PGRMC2 (if available)
Evolutionary constrained regions (ECRs) for PGRMC2: view image

Paralogs for PGRMC2 Gene

Paralogs for PGRMC2 Gene

(1) SIMAP similar genes for PGRMC2 Gene using alignment to 4 proteins:

  • U3KQ70_HUMAN
genes like me logo Genes that share paralogs with PGRMC2: view

Variants for PGRMC2 Gene

Sequence variations from dbSNP and Humsavar for PGRMC2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs41298555 uncertain-significance, Hirschsprung disease 1 128,287,678(-) C/T coding_sequence_variant, missense_variant
rs1000068824 -- 128,278,800(-) T/G intron_variant
rs1000069955 -- 128,281,080(-) T/G intron_variant
rs1000098126 -- 128,276,466(-) G/A intron_variant
rs1000126285 -- 128,276,740(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PGRMC2 Gene

Variant ID Type Subtype PubMed ID
esv3307446 CNV mobile element insertion 20981092
esv3310213 CNV mobile element insertion 20981092
esv3435397 CNV insertion 20981092
nsv292512 CNV insertion 16902084

Variation tolerance for PGRMC2 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGRMC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGRMC2 Gene

Disorders for PGRMC2 Gene

Additional Disease Information for PGRMC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PGRMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGRMC2 Gene

Publications for PGRMC2 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D … Falkenstein E (Biological chemistry 1998) 2 3 4 58
  2. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 44 58
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  4. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez DR … Menon R (American journal of obstetrics and gynecology 2009) 3 44 58
  5. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PMID: 19527514) Menon R … Thorsen P (Reproductive biology and endocrinology : RB&E 2009) 3 44 58

Products for PGRMC2 Gene

Sources for PGRMC2 Gene

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