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Aliases for TUBA1B Gene

Aliases for TUBA1B Gene

  • Tubulin Alpha 1b 2 3 5
  • Tubulin Alpha-Ubiquitous Chain 3 4
  • Tubulin, Alpha, Ubiquitous 2 3
  • Alpha-Tubulin Ubiquitous 3 4
  • Tubulin K-Alpha-1 3 4
  • Tubulin Alpha-1B Chain 3
  • Alpha Tubulin 3
  • K-ALPHA-1 3

External Ids for TUBA1B Gene

Previous GeneCards Identifiers for TUBA1B Gene

  • GC12M047809
  • GC12M049523
  • GC12M046552

Summaries for TUBA1B Gene

GeneCards Summary for TUBA1B Gene

TUBA1B (Tubulin Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include Kenny-Caffey Syndrome and Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Signaling events mediated by PRL and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA1A.

UniProtKB/Swiss-Prot for TUBA1B Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Tocris Summary for TUBA1B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBA1B Gene

Additional gene information for TUBA1B Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1B Gene

Genomics for TUBA1B Gene

GeneHancer (GH) Regulatory Elements for TUBA1B Gene

Promoters and enhancers for TUBA1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J049186 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.2 -57.0 -56983 4.3 PKNOX1 ATF1 ARNT SIN3A GLI4 YY1 ETS1 GLIS2 ZNF213 KLF7 TUBA1A TUBA1C TUBA1B LOC105369760 CCNT1 LOC390314 DDX23 KANSL2 KMT2D LMBR1L
GH12J049129 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.2 154 4.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000200309 GC12M049133 TUBA1B DDX23 LMBR1L SMARCD1 KMT2D LOC390314 KANSL2 BCDIN3D
GH12J049263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.7 -135.0 -135008 6.6 CLOCK DMAP1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC ZFP41 MEF2D TUBA1C ENSG00000258101 DDX23 KMT2D CCNT1 LMBR1L SMARCD1 LOC390314 KANSL2 BCDIN3D
GH12J048809 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 4.6 +318.2 318205 6.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B CACNB3 LOC101927241 DDX23 LMBR1L CCNT1 LOC390314 KMT2D SENP1 KANSL2 LOC101927267
GH12J049230 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -101.6 -101643 5.5 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 LMBR1L LOC105369760 KANSL2 TUBA1C KMT2D SMARCD1 TUBA1A CCNT1 PRKAG1 LOC390314
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUBA1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBA1B gene promoter:
  • TBP
  • C/EBPalpha
  • C/EBPbeta
  • p53
  • HNF-1
  • HNF-1A

Genomic Locations for TUBA1B Gene

Genomic Locations for TUBA1B Gene
chr12:49,127,782-49,131,521
(GRCh38/hg38)
Size:
3,740 bases
Orientation:
Minus strand
chr12:49,521,565-49,525,304
(GRCh37/hg19)
Size:
3,740 bases
Orientation:
Minus strand

Genomic View for TUBA1B Gene

Genes around TUBA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1B Gene

Proteins for TUBA1B Gene

  • Protein details for TUBA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68363-TBA1B_HUMAN
    Recommended name:
    Tubulin alpha-1B chain
    Protein Accession:
    P68363
    Secondary Accessions:
    • P04687
    • P05209
    • Q27I68
    • Q8WU19

    Protein attributes for TUBA1B Gene

    Size:
    451 amino acids
    Molecular mass:
    50152 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Three dimensional structures from OCA and Proteopedia for TUBA1B Gene

    Alternative splice isoforms for TUBA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBA1B Gene

Post-translational modifications for TUBA1B Gene

  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).
  • Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
  • Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
  • Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Tubulin alpha-1B chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
  • Detyrosinated tubulin alpha-1B chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
  • Ubiquitination at posLast=370370 and isoforms=2326
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBA1B Gene

Antibody Products

  • Abcam antibodies for TUBA1B

No data available for DME Specific Peptides for TUBA1B Gene

Domains & Families for TUBA1B Gene

Gene Families for TUBA1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TUBA1B Gene

Graphical View of Domain Structure for InterPro Entry

P68363

UniProtKB/Swiss-Prot:

TBA1B_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA1B: view

Function for TUBA1B Gene

Molecular function for TUBA1B Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Phenotypes From GWAS Catalog for TUBA1B Gene

Gene Ontology (GO) - Molecular Function for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 12090300
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 11698390
genes like me logo Genes that share ontologies with TUBA1B: view
genes like me logo Genes that share phenotypes with TUBA1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBA1B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBA1B Gene

Localization for TUBA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBA1B gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA,TAS 12090300
GO:0005881 cytoplasmic microtubule IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with TUBA1B: view

Pathways & Interactions for TUBA1B Gene

genes like me logo Genes that share pathways with TUBA1B: view

SIGNOR curated interactions for TUBA1B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000278 mitotic cell cycle IBA --
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA,TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
genes like me logo Genes that share ontologies with TUBA1B: view

Drugs & Compounds for TUBA1B Gene

(43) Drugs for TUBA1B Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2040
Taxol Approved August 1997 Pharma Agonist Promotes assembly and inhibits disassembly of microtubules 0
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Experimental Pharma Target 0
Epothilone D Experimental, Investigational Pharma Target 0

(31) Additional Compounds for TUBA1B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Noscapine hydrochloride
912-60-7

(5) Tocris Compounds for TUBA1B Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBA1B: view

Transcripts for TUBA1B Gene

mRNA/cDNA for TUBA1B Gene

Unigene Clusters for TUBA1B Gene

Tubulin, alpha 1b:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TUBA1B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1B Gene

No ASD Table

Relevant External Links for TUBA1B Gene

GeneLoc Exon Structure for
TUBA1B
ECgene alternative splicing isoforms for
TUBA1B

Expression for TUBA1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBA1B Gene

Protein differential expression in normal tissues from HIPED for TUBA1B Gene

This gene is overexpressed in Bone (29.6) and Brain (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TUBA1B Gene



Protein tissue co-expression partners for TUBA1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBA1B Gene:

TUBA1B

SOURCE GeneReport for Unigene cluster for TUBA1B Gene:

Hs.524390

Evidence on tissue expression from TISSUES for TUBA1B Gene

  • Lung(5)
  • Skin(5)
  • Nervous system(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Liver(4.9)
  • Kidney(4.8)
  • Muscle(4.8)
  • Pancreas(4.8)
  • Blood(4.7)
  • Stomach(4.5)
  • Heart(4.4)
  • Bone(4.1)
  • Spleen(3.3)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Gall bladder(2.3)
  • Adrenal gland(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with TUBA1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBA1B Gene

Orthologs for TUBA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
ManyToMany
LOC610636 33
  • 85.37 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBA1B 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBA1B 34 33
  • 99.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TUBA1B 34 33
  • 95.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tuba1b 16 34 33
  • 94.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 94 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TUBAL3 33
  • 81.85 (n)
-- 34
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 100 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tuba4a 33
  • 87.21 (n)<