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Aliases for CLEC4M Gene

Aliases for CLEC4M Gene

  • C-Type Lectin Domain Family 4 Member M 2 3 3 5
  • CD299 Antigen 2 3 4
  • Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin 2 3 4
  • CD209 Antigen-Like Protein 1 3 4
  • DC-SIGN-Related Protein 3 4
  • DC-SIGN2 3 4
  • DC-SIGNR 3 4
  • CD209L 3 4
  • L-SIGN 3 4
  • CD299 3 4
  • Liver/Lymph Node-Specific ICAM-3 Grabbing Non-Integrin 3
  • Liver/Lymph Node-Specific ICAM-3-Grabbing Non-Integrin 4
  • C-Type Lectin Domain Family 4, Member M 2
  • Mannose Binding C-Type Lectin DC-SIGNR 3
  • DCSIGNR 3
  • HP10347 3
  • CD209L1 4
  • LSIGN 3

External Ids for CLEC4M Gene

Previous HGNC Symbols for CLEC4M Gene

  • CD209L
  • CD299

Previous GeneCards Identifiers for CLEC4M Gene

  • GC19P007735
  • GC19P007828
  • GC19P007498

Summaries for CLEC4M Gene

Entrez Gene Summary for CLEC4M Gene

  • This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for CLEC4M Gene

CLEC4M (C-Type Lectin Domain Family 4 Member M) is a Protein Coding gene. Diseases associated with CLEC4M include Japanese Encephalitis and Severe Acute Respiratory Syndrome. Among its related pathways are C-type lectin receptor signaling pathway and Phagosome. Gene Ontology (GO) annotations related to this gene include calcium-dependent protein binding. An important paralog of this gene is CD209.

UniProtKB/Swiss-Prot for CLEC4M Gene

  • Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

  • (Microbial infection) Acts as an attachment receptor for Ebolavirus.

  • (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.

  • (Microbial infection) Acts as an attachment receptor for HIV-1.

  • (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.

  • (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.

  • (Microbial infection) Acts as an attachment receptor for Influenzavirus.

  • (Microbial infection) Acts as an attachment receptor for SARS coronavirus.

  • (Microbial infection) Acts as an attachment receptor for West-nile virus.

  • (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.

  • (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.

  • (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

Gene Wiki entry for CLEC4M Gene

Additional gene information for CLEC4M Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC4M Gene

Genomics for CLEC4M Gene

GeneHancer (GH) Regulatory Elements for CLEC4M Gene

Promoters and enhancers for CLEC4M Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007763 Promoter 0.6 EPDnew 650.7 +0.2 171 0.1 NR2F2 CLEC4M LOC105372263
GH19J007751 Enhancer 0.9 FANTOM5 ENCODE 5.1 -11.6 -11576 0.4 PKNOX1 EBF1 MEF2B IKZF1 ZNF143 NBN RUNX3 IKZF2 BCLAF1 RPL21P129 GC19P007750 CLEC4M FCER2 XAB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CLEC4M on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CLEC4M gene promoter:
  • ARP-1
  • FOXO1a
  • FOXO1
  • RP58
  • ISGF-3
  • Evi-1
  • c-Myb
  • Brachyury
  • NRSF form 2
  • NRSF form 1

Genomic Locations for CLEC4M Gene

Genomic Locations for CLEC4M Gene
chr19:7,763,054-7,770,558
(GRCh38/hg38)
Size:
7,505 bases
Orientation:
Plus strand
chr19:7,828,035-7,834,491
(GRCh37/hg19)
Size:
6,457 bases
Orientation:
Plus strand

Genomic View for CLEC4M Gene

Genes around CLEC4M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC4M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC4M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC4M Gene

Proteins for CLEC4M Gene

  • Protein details for CLEC4M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2X3-CLC4M_HUMAN
    Recommended name:
    C-type lectin domain family 4 member M
    Protein Accession:
    Q9H2X3
    Secondary Accessions:
    • A6NKI4
    • A8K8B3
    • Q69F40
    • Q969M4
    • Q96QP3
    • Q96QP4
    • Q96QP5
    • Q96QP6
    • Q9BXS3
    • Q9H2Q9
    • Q9H8F0
    • Q9Y2A8

    Protein attributes for CLEC4M Gene

    Size:
    399 amino acids
    Molecular mass:
    45350 Da
    Quaternary structure:
    • Homotetramer.
    • (Microbial infection) Interacts with ebola virus glycoprotein (PubMed:12050398, PubMed:12502850).
    • (Microbial infection) Interacts with hepatitis C virus E1 and E2 protein (PubMed:15371595, PubMed:16816373).
    • (Microbial infection) Interacts with HIV-1 gp120 (PubMed:21277928, PubMed:12502850).
    • (Microbial infection) Interacts with human coronavirus 229E spike glycoprotein.
    • (Microbial infection) Interacts with human cytomegalovirus/HHV-5 gB protein.
    • (Microbial infection) Interacts with influenzavirus hemagglutinin.
    • (Microbial infection) Interacts with SARS coronavirus spike glycoprotein.
    • (Microbial infection) Interacts with west-nile virus envelope protein E.
    • (Microbial infection) Interacts with Japanese encephalitis virus E protein.
    • (Microbial infection) Interacts with Marburg virus glycoprotein.
    • (Microbial infection) Interacts with M.bovis LprG.
    Miscellaneous:
    • In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells.
    SequenceCaution:
    • Sequence=AAR04559.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CLEC4M Gene

    Alternative splice isoforms for CLEC4M Gene

neXtProt entry for CLEC4M Gene

Post-translational modifications for CLEC4M Gene

  • Glycosylation at posLast=361361 and posLast=9292
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLEC4M Gene

Domains & Families for CLEC4M Gene

Gene Families for CLEC4M Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q9H2X3

UniProtKB/Swiss-Prot:

CLC4M_HUMAN :
  • The tandem repeat domain, also called neck domain, mediates oligomerization.
Domain:
  • The tandem repeat domain, also called neck domain, mediates oligomerization.
genes like me logo Genes that share domains with CLEC4M: view

Function for CLEC4M Gene

Molecular function for CLEC4M Gene

UniProtKB/Swiss-Prot Function:
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for HIV-1.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Influenzavirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for SARS coronavirus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for West-nile virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

Phenotypes From GWAS Catalog for CLEC4M Gene

Gene Ontology (GO) - Molecular Function for CLEC4M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IMP 15496474
GO:0005515 protein binding IPI 16246332
GO:0005537 mannose binding IEA --
GO:0030246 carbohydrate binding NAS 11337487
GO:0030369 ICAM-3 receptor activity NAS 11257134
genes like me logo Genes that share ontologies with CLEC4M: view
genes like me logo Genes that share phenotypes with CLEC4M: view

Animal Models for CLEC4M Gene

MGI Knock Outs for CLEC4M:

Animal Model Products

CRISPR Products

miRNA for CLEC4M Gene

miRTarBase miRNAs that target CLEC4M

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC4M

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC4M Gene

Localization for CLEC4M Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC4M Gene

Isoform 1: Cell membrane; Single-pass type II membrane protein.
Isoform 2: Cell membrane; Single-pass type II membrane protein.
Isoform 3: Cell membrane; Single-pass type II membrane protein.
Isoform 5: Secreted.
Isoform 6: Secreted.
Isoform 7: Secreted.
Isoform 10: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC4M gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for CLEC4M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm NAS 11337487
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10072769
GO:0016020 membrane TAS 11337487
genes like me logo Genes that share ontologies with CLEC4M: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CLEC4M Gene

Pathways & Interactions for CLEC4M Gene

genes like me logo Genes that share pathways with CLEC4M: view

Pathways by source for CLEC4M Gene

Gene Ontology (GO) - Biological Process for CLEC4M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006897 endocytosis IEA --
GO:0007159 leukocyte cell-cell adhesion NAS 11337487
GO:0009988 cell-cell recognition TAS 11337487
genes like me logo Genes that share ontologies with CLEC4M: view

No data available for SIGNOR curated interactions for CLEC4M Gene

Drugs & Compounds for CLEC4M Gene

(3) Drugs for CLEC4M Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0

(3) Additional Compounds for CLEC4M Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLEC4M: view

Transcripts for CLEC4M Gene

Unigene Clusters for CLEC4M Gene

C-type lectin domain family 4, member M:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CLEC4M

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC4M Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5: - - -

Relevant External Links for CLEC4M Gene

GeneLoc Exon Structure for
CLEC4M
ECgene alternative splicing isoforms for
CLEC4M

Expression for CLEC4M Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC4M Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC4M Gene

This gene is overexpressed in Liver (x38.1).

Protein differential expression in normal tissues from HIPED for CLEC4M Gene

This gene is overexpressed in Testis (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CLEC4M Gene



NURSA nuclear receptor signaling pathways regulating expression of CLEC4M Gene:

CLEC4M

SOURCE GeneReport for Unigene cluster for CLEC4M Gene:

Hs.421437

mRNA Expression by UniProt/SwissProt for CLEC4M Gene:

Q9H2X3-CLC4M_HUMAN
Tissue specificity: Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.

Evidence on tissue expression from TISSUES for CLEC4M Gene

  • Liver(4.6)
  • Nervous system(4.1)
  • Lymph node(2.9)
  • Spleen(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CLEC4M: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC4M Gene

Orthologs for CLEC4M Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC4M Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100611969 33
  • 98.21 (n)
CLEC4M 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd209a 33
  • 67.06 (n)
mouse
(Mus musculus)
Mammalia Cd209a 16 34 33
  • 64.62 (n)
Cd209e 34
  • 58 (a)
ManyToMany
Cd209d 34
  • 57 (a)
ManyToMany
Cd209c 34
  • 57 (a)
ManyToMany
Cd209b 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CD209 34
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CD209 34
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:174904 34 33
  • 49.36 (n)
ManyToMany
si:ch73-343l4.1 34
  • 39 (a)
ManyToMany
si:ch73-343l4.4 34
  • 36 (a)
ManyToMany
si:ch73-343l4.5 34
  • 36 (a)
ManyToMany
si:ch73-343l4.3 34
  • 34 (a)
ManyToMany
CABZ01029886.1 34
  • 33 (a)
ManyToMany
si:dkey-12f6.5 34
  • 32 (a)
ManyToMany
CU695221.2 34
  • 28 (a)
ManyToMany
si:ch211-133n4.11 34
  • 28 (a)
ManyToMany
si:dkey-181c13.1 34
  • 28 (a)
ManyToMany
BX936386.1 34
  • 27 (a)
ManyToMany
CR847844.3 34
  • 25 (a)
ManyToMany
illr1 34
  • 25 (a)
ManyToMany
CR847844.1 34
  • 24 (a)
ManyToMany
si:ch73-343l4.8 34
  • 24 (a)
ManyToMany
illr2 34
  • 23 (a)
ManyToMany
CR847844.2 34
  • 23 (a)
ManyToMany
CR847844.4 34
  • 23 (a)
ManyToMany
si:ch211-154o6.6 34
  • 22 (a)
ManyToMany
si:ch211-133n4.12 34
  • 22 (a)
ManyToMany
illr4 34
  • 22 (a)
ManyToMany
si:ch211-133n4.7 34
  • 21 (a)
ManyToMany
si:ch73-111e15.1 34
  • 21 (a)
ManyToMany
illr3 34
  • 21 (a)
ManyToMany
si:ch211-214k5.3 34
  • 20 (a)
ManyToMany
si:ch73-122g19.1 34
  • 19 (a)
ManyToMany
si:ch211-232p21.6 34
  • 19 (a)
ManyToMany
si:ch211-170d8.8 34
  • 18 (a)
ManyToMany
si:ch73-343l4.2 34
  • 17 (a)
ManyToMany
CR847844.6 34
  • 17 (a)
ManyToMany
cd209 34
  • 15 (a)
ManyToMany
CABZ01036814.1 34
  • 13 (a)
ManyToMany
si:ch73-343l4.6 34
  • 13 (a)
ManyToMany
si:dkey-187i8.2 34
  • 12 (a)
ManyToMany
Species where no ortholog for CLEC4M was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLEC4M Gene

ENSEMBL:
Gene Tree for CLEC4M (if available)
TreeFam:
Gene Tree for CLEC4M (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CLEC4M: view image

Paralogs for CLEC4M Gene

Paralogs for CLEC4M Gene

(11) SIMAP similar genes for CLEC4M Gene using alignment to 8 proteins:

  • CLC4M_HUMAN
  • D6W656_HUMAN
  • E7ENS9_HUMAN
  • H7BXE2_HUMAN
  • H7BXU4_HUMAN
  • M0QYX2_HUMAN
  • M0QZ42_HUMAN
  • Q2TB20_HUMAN
genes like me logo Genes that share paralogs with CLEC4M: view

Variants for CLEC4M Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC4M Gene

CLC4M_HUMAN-Q9H2X3
The number of repeats in the tandem repeat domain is shown to vary between 3 and 9 per allele thus contributing to a further variability in addition to alternative splicing. The shown 7 repeat-containing form has been shown to be the most frequent one (53.9%) in a study with 350 Caucasian individuals.

Sequence variations from dbSNP and Humsavar for CLEC4M Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000220929 -- 7,761,604(+) C/G upstream_transcript_variant
rs1000295277 -- 7,766,954(+) G/A intron_variant
rs1000532585 -- 7,769,760(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001226639 -- 7,762,818(+) A/G upstream_transcript_variant
rs1001414400 -- 7,767,917(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC4M Gene

Variant ID Type Subtype PubMed ID
esv1300284 CNV deletion 17803354
esv2718107 CNV deletion 23290073
esv2718108 CNV deletion 23290073
esv2751809 CNV gain 17911159
nsv1058579 CNV gain 25217958
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833732 CNV gain 17160897
nsv960781 CNV duplication 23825009

Variation tolerance for CLEC4M Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CLEC4M Gene

Human Gene Mutation Database (HGMD)
CLEC4M
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC4M

Disorders for CLEC4M Gene

MalaCards: The human disease database

(9) MalaCards diseases for CLEC4M Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
japanese encephalitis
  • japanese b encephalitis
severe acute respiratory syndrome
  • sars
west nile virus
  • west nile virus, susceptibility to
encephalitis
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CLEC4M

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CLEC4M: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLEC4M Gene

Publications for CLEC4M Gene

  1. Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1. (PMID: 19809496) Boily-Larouche G … Roger M (PloS one 2009) 3 22 44 58
  2. The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population. (PMID: 20003397) Li H … Zhang YP (BMC medical genetics 2009) 3 22 44 58
  3. Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection. (PMID: 18697825) Li H … Zhang YP (Journal of medical genetics 2008) 3 22 44 58
  4. Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individuals. (PMID: 17876530) Rathore A … Dhole TN (Journal of clinical immunology 2008) 3 22 44 58
  5. Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian Indians. (PMID: 18775666) Chaudhary O … Luthra K (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2008) 3 22 44 58

Products for CLEC4M Gene

Sources for CLEC4M Gene

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