Aliases for AKR1A1 Gene
External Ids for AKR1A1 Gene
Previous GeneCards Identifiers for AKR1A1 Gene
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
GeneCards Summary for AKR1A1 Gene
AKR1A1 (Aldo-Keto Reductase Family 1 Member A1) is a Protein Coding gene. Diseases associated with AKR1A1 include Ethylene Glycol Poisoning and Fetal Alcohol Syndrome. Among its related pathways are Glycosaminoglycan metabolism and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and alditol:NADP+ 1-oxidoreductase activity. An important paralog of this gene is AKR1B1.
UniProtKB/Swiss-Prot for AKR1A1 Gene
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).