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Aliases for NMUR1 Gene

Aliases for NMUR1 Gene

  • Neuromedin U Receptor 1 2 3 5
  • G-Protein Coupled Receptor FM-3 3 4
  • G-Protein Coupled Receptor 66 3 4
  • NMU-R1 3 4
  • GPR66 3 4
  • G Protein-Coupled Receptor 66 2
  • Neuromedin-U Receptor 1 3
  • (FM-3) 3
  • GPC-R 3
  • NMU1R 3
  • FM-3 3
  • FM3 3

External Ids for NMUR1 Gene

Previous HGNC Symbols for NMUR1 Gene

  • GPR66

Previous GeneCards Identifiers for NMUR1 Gene

  • GC02M232591
  • GC02M232213
  • GC02M232096
  • GC02M232387
  • GC02M224229

Summaries for NMUR1 Gene

GeneCards Summary for NMUR1 Gene

NMUR1 (Neuromedin U Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuromedin U receptor activity. An important paralog of this gene is NMUR2.

UniProtKB/Swiss-Prot for NMUR1 Gene

  • Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Tocris Summary for NMUR1 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery, whilst NMU2 is expressed in the CNS.

Gene Wiki entry for NMUR1 Gene

Additional gene information for NMUR1 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMUR1 Gene

Genomics for NMUR1 Gene

GeneHancer (GH) Regulatory Elements for NMUR1 Gene

Promoters and enhancers for NMUR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J231529 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 678.2 0.0 -28 1.7 PTBP1 PKNOX1 ATF1 RB1 SIN3A KLF5 ZNF48 RAD21 GLIS2 EGR1 NMUR1 RPL21P35
GH02J231513 Promoter/Enhancer 1.5 Ensembl ENCODE 25.9 +16.0 15994 2.6 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF207 LINC00471 NMUR1 TEX44 GC02P231518
GH02J231557 Enhancer 0.9 Ensembl ENCODE 38.2 -27.3 -27294 1.5 HDGF CTCF MAX RAD21 CC2D1A GATA3 ZNF316 ZNF143 SMC3 BCLAF1 NMUR1 RNU2-22P TEX44 ENSG00000233538 SNORA75 SNORD20 LINC00471 RPL21P35
GH02J231462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16 +66.1 66065 3.8 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 MLX ZFP64 ARID4B NEUROD1 SIN3A NCL DIS3L2 COPS7B RPL28P2 ENSG00000251485 LOC101928816 NMUR1 RNU2-22P ENSG00000224376 LINC00471
GH02J231553 Enhancer 0.8 Ensembl ENCODE 39.8 -24.3 -24305 2.1 HDGF ATF2 NR2F2 ZFHX2 EGR1 IKZF1 EED ZFP91 MYC RUNX3 NMUR1 RNU2-22P TEX44 ENSG00000233538 SNORA75 SNORD20 LINC00471 RPL21P35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMUR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMUR1 gene promoter:
  • En-1
  • Arnt
  • AhR
  • HTF
  • AML1a
  • AP-1
  • HEN1
  • HOXA5
  • Roaz

Genomic Locations for NMUR1 Gene

Genomic Locations for NMUR1 Gene
chr2:231,519,907-231,530,495
(GRCh38/hg38)
Size:
10,589 bases
Orientation:
Minus strand
chr2:232,387,871-232,395,206
(GRCh37/hg19)
Size:
7,336 bases
Orientation:
Minus strand

Genomic View for NMUR1 Gene

Genes around NMUR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMUR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMUR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR1 Gene

Proteins for NMUR1 Gene

  • Protein details for NMUR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB89-NMUR1_HUMAN
    Recommended name:
    Neuromedin-U receptor 1
    Protein Accession:
    Q9HB89
    Secondary Accessions:
    • O43664
    • Q7LDP6
    • Q8NE20

    Protein attributes for NMUR1 Gene

    Size:
    426 amino acids
    Molecular mass:
    47351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMUR1 Gene

Post-translational modifications for NMUR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMUR1 Gene

No data available for DME Specific Peptides for NMUR1 Gene

Domains & Families for NMUR1 Gene

Gene Families for NMUR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for NMUR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB89

UniProtKB/Swiss-Prot:

NMUR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMUR1: view

Function for NMUR1 Gene

Molecular function for NMUR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Phenotypes From GWAS Catalog for NMUR1 Gene

Gene Ontology (GO) - Molecular Function for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001607 neuromedin U receptor activity IDA 10894543
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10899166
GO:0008188 neuropeptide receptor activity TAS,IEA 10811630
GO:0042924 neuromedin U binding IDA 10894543
genes like me logo Genes that share ontologies with NMUR1: view
genes like me logo Genes that share phenotypes with NMUR1: view

Animal Models for NMUR1 Gene

MGI Knock Outs for NMUR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMUR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMUR1 Gene

Localization for NMUR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMUR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9782091
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 10899166
genes like me logo Genes that share ontologies with NMUR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMUR1 Gene

Pathways & Interactions for NMUR1 Gene

genes like me logo Genes that share pathways with NMUR1: view

SIGNOR curated interactions for NMUR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IDA 10899166
GO:0006821 chloride transport IDA 10899166
GO:0006939 smooth muscle contraction IEP 10899166
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NMUR1: view

Drugs & Compounds for NMUR1 Gene

(20) Drugs for NMUR1 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neuromedin U (rat) Pharma Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature 0
[<sup>125</sup>I]neuromedin U-23 (rat) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-25 (human) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-8 (pig) Pharma Agonist 0
neuromedin S-33 Pharma Full agonist, Agonist 0

(9) Additional Compounds for NMUR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for NMUR1 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist 843782-19-4
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature 117505-80-3
genes like me logo Genes that share compounds with NMUR1: view

Transcripts for NMUR1 Gene

mRNA/cDNA for NMUR1 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMUR1 Gene

Neuromedin U receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMUR1

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR1 Gene

No ASD Table

Relevant External Links for NMUR1 Gene

GeneLoc Exon Structure for
NMUR1
ECgene alternative splicing isoforms for
NMUR1

Expression for NMUR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMUR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMUR1 Gene

This gene is overexpressed in Whole Blood (x10.1).

NURSA nuclear receptor signaling pathways regulating expression of NMUR1 Gene:

NMUR1

SOURCE GeneReport for Unigene cluster for NMUR1 Gene:

Hs.471619

mRNA Expression by UniProt/SwissProt for NMUR1 Gene:

Q9HB89-NMUR1_HUMAN
Tissue specificity: Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.

Evidence on tissue expression from TISSUES for NMUR1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NMUR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMUR1 Gene

Orthologs for NMUR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMUR1 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NMUR1 34 33
  • 83.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NMUR1 34 33
  • 83.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nmur1 16 34 33
  • 78.41 (n)
rat
(Rattus norvegicus)
Mammalia Nmur1 33
  • 76.55 (n)
oppossum
(Monodelphis domestica)
Mammalia NMUR1 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMUR1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMUR1 34 33
  • 66.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMUR1 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498264 33
  • 61.42 (n)
zebrafish
(Danio rerio)
Actinopterygii nmur1 34 33
  • 63.97 (n)
OneToMany
NMUR1 (1 of 2) 34
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGHP1 33
  • 52.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pk1r 34
  • 28 (a)
ManyToMany
capaR 34
  • 27 (a)
ManyToMany
CG8795 34
  • 20 (a)
ManyToMany
CG8784 34
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nmur-2 34
  • 26 (a)
ManyToMany
nmur-1 34
  • 25 (a)
ManyToMany
nmur-4 34
  • 24 (a)
ManyToMany
nmur-3 34
  • 20 (a)
ManyToMany
Species where no ortholog for NMUR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR1 Gene

ENSEMBL:
Gene Tree for NMUR1 (if available)
TreeFam:
Gene Tree for NMUR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMUR1: view image

Paralogs for NMUR1 Gene

Paralogs for NMUR1 Gene

(5) SIMAP similar genes for NMUR1 Gene using alignment to 2 proteins:

  • NMUR1_HUMAN
  • L8E9D8_HUMAN
genes like me logo Genes that share paralogs with NMUR1: view

Variants for NMUR1 Gene

Sequence variations from dbSNP and Humsavar for NMUR1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000290657 -- 231,527,987(-) C/T intron_variant
rs1000306403 -- 231,522,068(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000583643 -- 231,527,623(-) G/C intron_variant
rs1000640571 -- 231,523,700(-) C/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000691403 -- 231,523,307(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NMUR1 Gene

Variant ID Type Subtype PubMed ID
nsv834567 CNV gain 17160897
nsv999161 CNV gain 25217958

Variation tolerance for NMUR1 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMUR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMUR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMUR1 Gene

Disorders for NMUR1 Gene

Additional Disease Information for NMUR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NMUR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMUR1 Gene

Publications for NMUR1 Gene

  1. Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. (PMID: 9782091) Tan CP … Howard AD (Genomics 1998) 2 3 4 22 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. (PMID: 10783389) Fujii R … Fujino M (The Journal of biological chemistry 2000) 3 22 58
  5. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. (PMID: 10899166) Raddatz R … Adham N (The Journal of biological chemistry 2000) 3 4 58

Products for NMUR1 Gene

Sources for NMUR1 Gene

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