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Aliases for ZNF267 Gene

Aliases for ZNF267 Gene

  • Zinc Finger Protein 267 2 3 3 5
  • Zinc Finger Protein HZF2 3 4
  • Zinc Finger Protein 2 3
  • Zinc Finger (C2H2) 3
  • HZF2 3

External Ids for ZNF267 Gene

Previous GeneCards Identifiers for ZNF267 Gene

  • GC16P030966
  • GC16P032222
  • GC16P031723
  • GC16P031760
  • GC16P031633
  • GC16P031792
  • GC16P029445

Summaries for ZNF267 Gene

GeneCards Summary for ZNF267 Gene

ZNF267 (Zinc Finger Protein 267) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF254.

UniProtKB/Swiss-Prot for ZNF267 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF267 Gene

Additional gene information for ZNF267 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF267 Gene

Genomics for ZNF267 Gene

GeneHancer (GH) Regulatory Elements for ZNF267 Gene

Promoters and enhancers for ZNF267 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J031873 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 677.8 +2.5 2528 6.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF267 PIR46248 ARMC5 CLUHP3 GC16M031894
GH16J031879 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +6.8 6783 2 PKNOX1 ATF1 ARNT FEZF1 ZNF766 FOS ATF7 SP3 ZNF592 ATF4 ZNF267 ARMC5 CLUHP3 PIR46248 GC16M031894
GH16J031868 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.2 -3.9 -3861 2.6 PKNOX1 RB1 INSM2 KLF17 YBX1 BATF IRF4 RAD21 YY1 ZNF335 ENSG00000259874 ZNF267 CLUHP3 ARMC5 RBM22P13
GH16J031894 Enhancer 0.4 FANTOM5 dbSUPER 6.5 +20.8 20822 0.4 LOC100422713 GC16M031894 ZNF267 CLUHP3 PIR46248
GH16J031883 Enhancer 0.5 dbSUPER 0.4 +13.3 13269 6.6 ZNF316 CBX3 MAFK EMSY FUS CLUHP3 GC16M031894 ZNF267 PIR46248
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF267 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF267 gene promoter:
  • MRF-2
  • AML1a
  • En-1
  • GATA-1
  • XBP-1
  • C/EBPalpha
  • Nkx2-5
  • HTF
  • p53
  • Gfi-1

Genomic Locations for ZNF267 Gene

Genomic Locations for ZNF267 Gene
chr16:31,873,758-31,917,357
(GRCh38/hg38)
Size:
43,600 bases
Orientation:
Plus strand
chr16:31,885,079-31,928,668
(GRCh37/hg19)
Size:
43,590 bases
Orientation:
Plus strand

Genomic View for ZNF267 Gene

Genes around ZNF267 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF267 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF267 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF267 Gene

Proteins for ZNF267 Gene

  • Protein details for ZNF267 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14586-ZN267_HUMAN
    Recommended name:
    Zinc finger protein 267
    Protein Accession:
    Q14586
    Secondary Accessions:
    • A0JNZ9
    • Q8NE41
    • Q9NRJ0

    Protein attributes for ZNF267 Gene

    Size:
    743 amino acids
    Molecular mass:
    87376 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF267 Gene

Post-translational modifications for ZNF267 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF267 Gene

Domains & Families for ZNF267 Gene

Gene Families for ZNF267 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF267 Gene

Suggested Antigen Peptide Sequences for ZNF267 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14586

UniProtKB/Swiss-Prot:

ZN267_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF267: view

Function for ZNF267 Gene

Molecular function for ZNF267 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF267: view
genes like me logo Genes that share phenotypes with ZNF267: view

Animal Model Products

miRNA for ZNF267 Gene

miRTarBase miRNAs that target ZNF267

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF267 Gene

Localization for ZNF267 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF267 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF267 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF267: view

Pathways & Interactions for ZNF267 Gene

SuperPathways for ZNF267 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF267: view

Pathways by source for ZNF267 Gene

2 Reactome pathways for ZNF267 Gene

Gene Ontology (GO) - Biological Process for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development TAS 7865130
genes like me logo Genes that share ontologies with ZNF267: view

No data available for SIGNOR curated interactions for ZNF267 Gene

Drugs & Compounds for ZNF267 Gene

No Compound Related Data Available

Transcripts for ZNF267 Gene

Unigene Clusters for ZNF267 Gene

Zinc finger protein 267:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF267 Gene

No ASD Table

Relevant External Links for ZNF267 Gene

GeneLoc Exon Structure for
ZNF267
ECgene alternative splicing isoforms for
ZNF267

Expression for ZNF267 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF267 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF267 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF267 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF267 Gene



Protein tissue co-expression partners for ZNF267 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF267 Gene:

ZNF267

SOURCE GeneReport for Unigene cluster for ZNF267 Gene:

Hs.460645
genes like me logo Genes that share expression patterns with ZNF267: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF267 Gene

Orthologs for ZNF267 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF267 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF267 34 33
  • 99.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia D3Ertd254e 16 33
  • 60.59 (n)
Gm19965 34
  • 26 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100359945 33
  • 59.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Kr-h1 35
  • 47 (a)
CG18262 35
  • 46 (a)
Cf2 35
  • 45 (a)
CG3281 35
  • 37 (a)
CG17612 35
  • 30 (a)
Species where no ortholog for ZNF267 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF267 Gene

ENSEMBL:
Gene Tree for ZNF267 (if available)
TreeFam:
Gene Tree for ZNF267 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF267: view image

Paralogs for ZNF267 Gene

(510) SIMAP similar genes for ZNF267 Gene using alignment to 5 proteins:

  • ZN267_HUMAN
  • H3BMG2_HUMAN
  • H3BNA3_HUMAN
  • H3BPW2_HUMAN
  • I3L4I6_HUMAN

Pseudogenes.org Pseudogenes for ZNF267 Gene

genes like me logo Genes that share paralogs with ZNF267: view

Variants for ZNF267 Gene

Sequence variations from dbSNP and Humsavar for ZNF267 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000095786 -- 31,899,532(+) A/C intron_variant
rs1000194665 -- 31,876,133(+) A/G intron_variant
rs1000247034 -- 31,876,497(+) G/T intron_variant
rs1000478820 -- 31,886,372(+) T/C intron_variant
rs1000480980 -- 31,918,176(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF267 Gene

Variant ID Type Subtype PubMed ID
dgv50e203 CNV gain+loss 21179565
esv2375355 CNV deletion 18987734
esv2640928 CNV deletion 19546169
esv2666562 CNV deletion 23128226
esv29641 CNV loss 19812545
esv3570465 CNV gain 25503493
esv3638413 CNV loss 21293372
nsv1113783 CNV deletion 24896259
nsv428325 CNV gain+loss 18775914
nsv475846 CNV novel sequence insertion 20440878
nsv833196 CNV gain 17160897

Variation tolerance for ZNF267 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF267 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF267

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF267 Gene

Disorders for ZNF267 Gene

Additional Disease Information for ZNF267

No disorders were found for ZNF267 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF267 Gene

Publications for ZNF267 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4 58
  2. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. (PMID: 16054593) Schnabl B … Schölmerich J (Biochemical and biophysical research communications 2005) 3 22 58
  3. Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y. (PMID: 15814297) Hu K … Schnabl B (Biochimica et biophysica acta 2005) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF267 Gene

Sources for ZNF267 Gene

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