Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAMP1 Gene

Aliases for RAMP1 Gene

  • Receptor Activity Modifying Protein 1 2 3 5
  • CRLR Activity-Modifying Protein 1 3 4
  • Calcitonin Receptor-Like Receptor Activity Modifying Protein 1 3
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1 4
  • Receptor (G Protein-Coupled) Activity Modifying Protein 1 3
  • Receptor (Calcitonin) Activity Modifying Protein 1 3
  • Receptor Activity-Modifying Protein 1 3

External Ids for RAMP1 Gene

Previous GeneCards Identifiers for RAMP1 Gene

  • GC02P236817
  • GC02P237449
  • GC02P238783
  • GC02P239055
  • GC02P238550
  • GC02P238432
  • GC02P230560
  • GC02P238767

Summaries for RAMP1 Gene

Entrez Gene Summary for RAMP1 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for RAMP1 Gene

RAMP1 (Receptor Activity Modifying Protein 1) is a Protein Coding gene. Diseases associated with RAMP1 include Migraine With Or Without Aura 1. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is RAMP3.

UniProtKB/Swiss-Prot for RAMP1 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

Tocris Summary for RAMP1 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP1 Gene

Additional gene information for RAMP1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP1 Gene

Genomics for RAMP1 Gene

GeneHancer (GH) Regulatory Elements for RAMP1 Gene

Promoters and enhancers for RAMP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J237858 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 655.6 +1.5 1531 4.8 FOXA2 MLX ARID4B SIN3A ZNF48 ARID2 ZNF143 RXRA SP5 REST RAMP1 GC02P237871
GH02J237894 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20 +38.2 38203 5.5 HDGF FOXA2 YBX1 KLF5 SCRT2 ZNF207 ATF7 BCLAF1 IKZF2 CREM RAMP1 KLHL30 PER2 LRRFIP1 ESPNL UBE2F ILKAP ENSG00000263723 LOC105373960
GH02J237903 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26 +46.1 46126 3.3 PKNOX1 EBF1 TCF12 ZFHX2 POLR2A EGR1 EED CBFA2T2 ATF7 IKZF2 RAMP1 SCLY UBE2F KLHL30 PER2 LOC105373960 ENSG00000263723
GH02J237963 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 11.7 +107.9 107882 6.2 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D UBE2F UBE2F-SCLY ILKAP SCLY RAMP1 ESPNL KLHL30 ASB1 HES6 LRRFIP1
GH02J237882 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +27.0 27030 6.2 FOXA2 RAD21 RARA YY1 EGR1 RCOR1 ATF7 FOS RXRA CEBPB RAMP1 UBE2F LRRFIP1 ENSG00000263723 LOC105373960
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAMP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAMP1 gene promoter:
  • Nkx6-1
  • FOXC1
  • GATA-6
  • AP-4
  • MRF-2
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FAC1
  • Lmo2

Genomic Locations for RAMP1 Gene

Genomic Locations for RAMP1 Gene
53,222 bases
Plus strand
53,221 bases
Plus strand

Genomic View for RAMP1 Gene

Genes around RAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP1 Gene

Proteins for RAMP1 Gene

  • Protein details for RAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor activity-modifying protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6FGS5

    Protein attributes for RAMP1 Gene

    148 amino acids
    Molecular mass:
    16988 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP1.

    Three dimensional structures from OCA and Proteopedia for RAMP1 Gene

neXtProt entry for RAMP1 Gene

Post-translational modifications for RAMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAMP1 Gene

Domains & Families for RAMP1 Gene

Gene Families for RAMP1 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for RAMP1 Gene

Suggested Antigen Peptide Sequences for RAMP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RAMP family.
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP1: view

Function for RAMP1 Gene

Molecular function for RAMP1 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

Phenotypes From GWAS Catalog for RAMP1 Gene

Gene Ontology (GO) - Molecular Function for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001635 calcitonin gene-related peptide receptor activity IPI 9620797
GO:0005515 protein binding IPI 9620797
GO:0008565 protein transporter activity IEA,IDA 9620797
GO:0015026 coreceptor activity IEA --
GO:0038023 signaling receptor activity IDA 14722252
genes like me logo Genes that share ontologies with RAMP1: view
genes like me logo Genes that share phenotypes with RAMP1: view

Animal Models for RAMP1 Gene

MGI Knock Outs for RAMP1:
  • Ramp1 Ramp1<tm1.1Tsuj>
  • Ramp1 Ramp1<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for RAMP1

miRNA for RAMP1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAMP1 Gene

Localization for RAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAMP1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
GO:0009986 cell surface IDA 14722252
genes like me logo Genes that share ontologies with RAMP1: view

Pathways & Interactions for RAMP1 Gene

genes like me logo Genes that share pathways with RAMP1: view

Gene Ontology (GO) - Biological Process for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006816 calcium ion transport IDA 10882736
GO:0006886 intracellular protein transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IPI 9620797
genes like me logo Genes that share ontologies with RAMP1: view

No data available for SIGNOR curated interactions for RAMP1 Gene

Drugs & Compounds for RAMP1 Gene

(10) Drugs for RAMP1 Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43
Salmon Calcitonin Approved, Investigational Pharma binder 178
CGRP (rat) Pharma Potent vasodilator 0
PHM 27 (human) Pharma Potent calcitonin receptor agonist; endogenous analog of human VIP 0
SUN-B 8155 Pharma Non-peptide calcitonin (CT) receptor agonist 0

(3) Additional Compounds for RAMP1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
Calcitonin (salmon)

(5) Tocris Compounds for RAMP1 Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with RAMP1: view

Transcripts for RAMP1 Gene

Unigene Clusters for RAMP1 Gene

Receptor (G protein-coupled) activity modifying protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: - -
SP3: -

Relevant External Links for RAMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP1 Gene

This gene is overexpressed in Uterus (x5.0).

Protein differential expression in normal tissues from HIPED for RAMP1 Gene

This gene is overexpressed in Liver (60.1) and Spinal cord (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAMP1 Gene

Protein tissue co-expression partners for RAMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAMP1 Gene:


SOURCE GeneReport for Unigene cluster for RAMP1 Gene:


mRNA Expression by UniProt/SwissProt for RAMP1 Gene:

Tissue specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.

Evidence on tissue expression from TISSUES for RAMP1 Gene

  • Nervous system(4.7)
  • Lung(4.2)
  • Muscle(2.8)
  • Heart(2.7)
genes like me logo Genes that share expression patterns with RAMP1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAMP1 Gene

Orthologs for RAMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAMP1 34 33
  • 99.1 (n)
(Rattus norvegicus)
Mammalia Ramp1 33
  • 79.5 (n)
(Mus musculus)
Mammalia Ramp1 16 34 33
  • 79.28 (n)
(Canis familiaris)
Mammalia RAMP1 34 33
  • 79.08 (n)
(Ornithorhynchus anatinus)
Mammalia RAMP1 34
  • 52 (a)
(Bos Taurus)
Mammalia RAMP1 34
  • 38 (a)
(Gallus gallus)
Aves RAMP1 34
  • 56 (a)
(Anolis carolinensis)
Reptilia RAMP1 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp1 33
  • 58.11 (n)
(Danio rerio)
Actinopterygii zgc:91818 33
  • 57.55 (n)
RAMP1 34
  • 48 (a)
Species where no ortholog for RAMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP1 Gene

Gene Tree for RAMP1 (if available)
Gene Tree for RAMP1 (if available)
Evolutionary constrained regions (ECRs) for RAMP1: view image

Paralogs for RAMP1 Gene

Paralogs for RAMP1 Gene

(2) SIMAP similar genes for RAMP1 Gene using alignment to 4 proteins:

  • E9PC20_HUMAN
  • Q53SN3_HUMAN
  • Q53T50_HUMAN
genes like me logo Genes that share paralogs with RAMP1: view

Variants for RAMP1 Gene

Sequence variations from dbSNP and Humsavar for RAMP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000069537 -- 237,860,308(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000092442 -- 237,865,938(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000126621 -- 237,903,059(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000155108 -- 237,876,597(+) G/A intron_variant
rs1000213712 -- 237,884,991(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAMP1 Gene

Variant ID Type Subtype PubMed ID
esv2657266 CNV deletion 23128226
esv2661727 CNV deletion 23128226
esv274938 CNV loss 21479260
esv2760579 CNV gain 21179565
esv3594749 CNV gain 21293372
esv3594750 CNV gain 21293372
esv3594752 CNV gain 21293372
nsv1000252 CNV loss 25217958
nsv1136488 CNV deletion 24896259
nsv473032 CNV novel sequence insertion 20440878
nsv508205 CNV deletion 20534489
nsv516443 CNV gain+loss 19592680
nsv519581 CNV loss 19592680
nsv527428 CNV loss 19592680
nsv584754 CNV loss 21841781

Variation tolerance for RAMP1 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP1 Gene

Disorders for RAMP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAMP1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search RAMP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAMP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAMP1 Gene

Publications for RAMP1 Gene

  1. Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction. (PMID: 19710695) Nakazato T … Doba N (Journal of human hypertension 2010) 3 22 44 58
  2. Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. (PMID: 18725456) Kusano S … Yokoyama S (Protein science : a publication of the Protein Society 2008) 3 4 22 58
  3. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PMID: 9620797) McLatchie LM … Foord SM (Nature 1998) 3 4 22 58
  4. Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. (PMID: 20826335) ter Haar E … Moore JM (Structure (London, England : 1993) 2010) 3 4 58
  5. Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension. (PMID: 20100989) Sabharwal R … Chapleau MW (Hypertension (Dallas, Tex. : 1979) 2010) 3 22 58

Products for RAMP1 Gene

Sources for RAMP1 Gene

Loading form....