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Aliases for LRRC23 Gene

Aliases for LRRC23 Gene

  • Leucine Rich Repeat Containing 23 2 3 5
  • Leucine-Rich Protein B7 3 4
  • LRPB7 3 4
  • Leucine-Rich Repeat-Containing Protein 23 3

External Ids for LRRC23 Gene

Previous GeneCards Identifiers for LRRC23 Gene

  • GC12P006982

Summaries for LRRC23 Gene

GeneCards Summary for LRRC23 Gene

LRRC23 (Leucine Rich Repeat Containing 23) is a Protein Coding gene. An important paralog of this gene is LRRC9.

Gene Wiki entry for LRRC23 Gene

Additional gene information for LRRC23 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC23 Gene

Genomics for LRRC23 Gene

GeneHancer (GH) Regulatory Elements for LRRC23 Gene

Promoters and enhancers for LRRC23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006866 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 657.6 -3.3 -3325 8.5 HDGF SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 SPSB2 LRRC23 TPI1 PIR60823 ING4 ZNF384 ATN1 ENSG00000219410 LOC100419928 NCAPD2
GH12J006913 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 680.9 +41.4 41366 2.5 HDGF FOXA2 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 FOS SP3 YY2 LRRC23 ENO2 ENSG00000247853 SPSB2 NCAPD2 ZNF384 ENSG00000219410 C1RL ATN1
GH12J006903 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 688.6 +31.3 31313 1.9 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 ZFP91 LRRC23 SPSB2 ENSG00000219410 CHD4 ENSG00000275703 ENO2
GH12J006923 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 40.2 +53.6 53582 6.8 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF143 FOS ATN1 ZNF384 LRRC23 CHD4 ENSG00000219410 ENSG00000247853 SCARNA12 ENSG00000126749 PHB2 RPL13P5
GH12J006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.4 +80.1 80089 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 EMG1 ZNF384 ENSG00000219410 ENSG00000247853 SPSB2 SCARNA12 NCAPD2 ENSG00000256967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LRRC23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC23 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for LRRC23 Gene

Genomic Locations for LRRC23 Gene
chr12:6,873,569-6,914,243
(GRCh38/hg38)
Size:
40,675 bases
Orientation:
Plus strand
chr12:6,982,733-7,023,407
(GRCh37/hg19)
Size:
40,675 bases
Orientation:
Plus strand

Genomic View for LRRC23 Gene

Genes around LRRC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC23 Gene

Proteins for LRRC23 Gene

  • Protein details for LRRC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EV4-LRC23_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 23
    Protein Accession:
    Q53EV4
    Secondary Accessions:
    • A8K8C6
    • D3DUT1
    • Q8N6K6
    • Q92977
    • Q99620

    Protein attributes for LRRC23 Gene

    Size:
    343 amino acids
    Molecular mass:
    39761 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC23 Gene

Post-translational modifications for LRRC23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for LRRC23
  • Boster Bio Antibodies for LRRC23

No data available for DME Specific Peptides for LRRC23 Gene

Domains & Families for LRRC23 Gene

Gene Families for LRRC23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC23 Gene

Suggested Antigen Peptide Sequences for LRRC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC23: view

No data available for UniProtKB/Swiss-Prot for LRRC23 Gene

Function for LRRC23 Gene

Phenotypes From GWAS Catalog for LRRC23 Gene

Gene Ontology (GO) - Molecular Function for LRRC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LRRC23: view
genes like me logo Genes that share phenotypes with LRRC23: view

Animal Models for LRRC23 Gene

MGI Knock Outs for LRRC23:
  • Lrrc23 Lrrc23<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC23 Gene

Localization for LRRC23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC23 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with LRRC23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC23 Gene

Pathways & Interactions for LRRC23 Gene

SuperPathways for LRRC23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LRRC23: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC23 Gene

Drugs & Compounds for LRRC23 Gene

No Compound Related Data Available

Transcripts for LRRC23 Gene

mRNA/cDNA for LRRC23 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC23 Gene

Leucine rich repeat containing 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7:
SP8:
SP9: - - - - - - -
SP10: - -
SP11: -
SP12:
SP13: - - - - - - - -

Relevant External Links for LRRC23 Gene

GeneLoc Exon Structure for
LRRC23
ECgene alternative splicing isoforms for
LRRC23

Expression for LRRC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC23 Gene

Protein differential expression in normal tissues from HIPED for LRRC23 Gene

This gene is overexpressed in Platelet (59.6) and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC23 Gene



Protein tissue co-expression partners for LRRC23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC23 Gene:

LRRC23

SOURCE GeneReport for Unigene cluster for LRRC23 Gene:

Hs.155586
genes like me logo Genes that share expression patterns with LRRC23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC23 Gene

Orthologs for LRRC23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LRRC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC23 34 33
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC23 34 33
  • 87.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC23 34 33
  • 87.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911585 33
  • 80.61 (n)
mouse
(Mus musculus)
Mammalia Lrrc23 16 34 33
  • 80.6 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC23 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC23 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC23 33
  • 65.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc23 33
  • 64.21 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc23 34 33
  • 56.89 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea magu-3 34
  • 10 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUK1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
Species where no ortholog for LRRC23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC23 Gene

ENSEMBL:
Gene Tree for LRRC23 (if available)
TreeFam:
Gene Tree for LRRC23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for LRRC23: view image

Paralogs for LRRC23 Gene

Paralogs for LRRC23 Gene

(1) SIMAP similar genes for LRRC23 Gene using alignment to 6 proteins:

  • LRC23_HUMAN
  • C9JEW3_HUMAN
  • C9JKE8_HUMAN
  • C9JQN5_HUMAN
  • E9PDZ4_HUMAN
  • F2Z299_HUMAN
genes like me logo Genes that share paralogs with LRRC23: view

Variants for LRRC23 Gene

Sequence variations from dbSNP and Humsavar for LRRC23 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000161856 -- 6,907,725(+) T/G intron_variant
rs1000287296 -- 6,904,937(+) T/C 5_prime_UTR_variant, intron_variant
rs1000412685 -- 6,911,344(+) A/G intron_variant
rs1000589575 -- 6,903,196(+) G/T upstream_transcript_variant
rs1000618975 -- 6,903,365(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC23 Gene

Variant ID Type Subtype PubMed ID
esv2745480 CNV deletion 23290073
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv480716 CNV novel sequence insertion 20440878
nsv509453 CNV insertion 20534489
nsv557261 CNV loss 21841781
nsv819094 CNV loss 19587683
nsv819916 CNV loss 19587683
nsv832324 CNV loss 17160897

Variation tolerance for LRRC23 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.46; 94.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC23 Gene

Disorders for LRRC23 Gene

Additional Disease Information for LRRC23

No disorders were found for LRRC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC23 Gene

Publications for LRRC23 Gene

  1. Expression and localization of leucine-rich B7 protein in human ocular tissues. (PMID: 16030496) Tasheva ES … Conrad GW (Molecular vision 2005) 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for LRRC23 Gene

Sources for LRRC23 Gene

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