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Aliases for MPHOSPH10 Gene

Aliases for MPHOSPH10 Gene

  • M-Phase Phosphoprotein 10 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 106 2 3
  • U3 Small Nucleolar Ribonucleoprotein 2 3
  • M Phase Phosphoprotein 10 3 4
  • MPP10 3 4
  • M-Phase Phosphoprotein 10 (U3 Small Nucleolar Ribonucleoprotein) 2
  • U3 Small Nucleolar Ribonucleoprotein Protein MPP10 3
  • PPP1R106 3
  • MPP10P 3
  • CT90 3

External Ids for MPHOSPH10 Gene

Previous GeneCards Identifiers for MPHOSPH10 Gene

  • GC02P071366
  • GC02P071569
  • GC02P071331
  • GC02P071269
  • GC02P071210
  • GC02P071358
  • GC02P071094

Summaries for MPHOSPH10 Gene

Entrez Gene Summary for MPHOSPH10 Gene

  • This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010]

GeneCards Summary for MPHOSPH10 Gene

MPHOSPH10 (M-Phase Phosphoprotein 10) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

UniProtKB/Swiss-Prot for MPHOSPH10 Gene

  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Gene Wiki entry for MPHOSPH10 Gene

Additional gene information for MPHOSPH10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPHOSPH10 Gene

Genomics for MPHOSPH10 Gene

GeneHancer (GH) Regulatory Elements for MPHOSPH10 Gene

Promoters and enhancers for MPHOSPH10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J071128 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 667.2 +0.4 391 4.4 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A SSRP1 MPHOSPH10 MCEE TEX261 TIA1 ZNF638 NAGK ANKRD53 CLEC4F GC02P071160
GH02J071226 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.7 +96.7 96720 1.9 HDGF PKNOX1 ATF1 FOXA2 SIN3A FEZF1 GLI4 ZNF2 ZBTB7B IRF4 PAIP2B TEX261 TIA1 ANKRD53 MPHOSPH10 CLEC4F ZNF638 ENSG00000233870
GH02J070246 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.5 -882.1 -882053 3.3 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 TIA1 C2orf42 TRG-CCC2-1 PCBP1-AS1 TEX261 GMCL1 CLEC4F ANKRD53 MPHOSPH10 CD207
GH02J071062 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.2 -61.7 -61709 11.8 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC NAGK ENSG00000272735 TIA1 ZNF638 MPHOSPH10 OR7E62P ENSG00000236469 GC02P071073
GH02J070189 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -939.5 -939500 2.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 C2orf42 TIA1 PCBP1-AS1 TEX261 CD207 GMCL1 PCYOX1 MPHOSPH10 CLEC4F ASPRV1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MPHOSPH10 gene promoter:
  • IRF-2
  • Meis-1a
  • Meis-1
  • HOXA9B
  • HOXA9
  • C/EBPalpha
  • Nkx5-1
  • RFX1
  • HOXA3
  • C/EBPbeta

Genomic Locations for MPHOSPH10 Gene

Genomic Locations for MPHOSPH10 Gene
19,789 bases
Plus strand
19,789 bases
Plus strand

Genomic View for MPHOSPH10 Gene

Genes around MPHOSPH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MPHOSPH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MPHOSPH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPHOSPH10 Gene

Proteins for MPHOSPH10 Gene

  • Protein details for MPHOSPH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein MPP10
    Protein Accession:
    Secondary Accessions:
    • A0AVJ8

    Protein attributes for MPHOSPH10 Gene

    681 amino acids
    Molecular mass:
    78864 Da
    Quaternary structure:
    • Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4.

neXtProt entry for MPHOSPH10 Gene

Post-translational modifications for MPHOSPH10 Gene

Other Protein References for MPHOSPH10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MPHOSPH10 Gene

Domains & Families for MPHOSPH10 Gene

Gene Families for MPHOSPH10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MPHOSPH10 Gene


Suggested Antigen Peptide Sequences for MPHOSPH10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MPP10 family.
  • Belongs to the MPP10 family.
genes like me logo Genes that share domains with MPHOSPH10: view

Function for MPHOSPH10 Gene

Molecular function for MPHOSPH10 Gene

UniProtKB/Swiss-Prot Function:
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

Phenotypes From GWAS Catalog for MPHOSPH10 Gene

Gene Ontology (GO) - Molecular Function for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 12655004
genes like me logo Genes that share ontologies with MPHOSPH10: view
genes like me logo Genes that share phenotypes with MPHOSPH10: view

Animal Model Products

CRISPR Products

miRNA for MPHOSPH10 Gene

miRTarBase miRNAs that target MPHOSPH10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPHOSPH10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MPHOSPH10 Gene

Localization for MPHOSPH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus (PubMed:9450966). After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase (PubMed:9450966). In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin (PubMed:9450966). The reassociation with nucleolus is preceeded by the arrival of fibrillarin (PubMed:9450966). {ECO:0000269 PubMed:9450966}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MPHOSPH10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA 9450966
GO:0005732 small nucleolar ribonucleoprotein complex NAS,IEA 9450966
genes like me logo Genes that share ontologies with MPHOSPH10: view

Pathways & Interactions for MPHOSPH10 Gene

genes like me logo Genes that share pathways with MPHOSPH10: view

Gene Ontology (GO) - Biological Process for MPHOSPH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions NAS 9450966
GO:0006364 rRNA processing TAS,IEA --
GO:0006396 RNA processing NAS 9450966
GO:0008380 RNA splicing NAS 9450966
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with MPHOSPH10: view

No data available for SIGNOR curated interactions for MPHOSPH10 Gene

Drugs & Compounds for MPHOSPH10 Gene

No Compound Related Data Available

Transcripts for MPHOSPH10 Gene

mRNA/cDNA for MPHOSPH10 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(143) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MPHOSPH10 Gene

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MPHOSPH10

Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: -
SP3: -
SP5: -

Relevant External Links for MPHOSPH10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MPHOSPH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MPHOSPH10 Gene

Protein differential expression in normal tissues from HIPED for MPHOSPH10 Gene

This gene is overexpressed in Heart (10.5), Peripheral blood mononuclear cells (10.4), Blymphocyte (8.5), Lung (7.4), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MPHOSPH10 Gene

Protein tissue co-expression partners for MPHOSPH10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MPHOSPH10 Gene:


SOURCE GeneReport for Unigene cluster for MPHOSPH10 Gene:


Evidence on tissue expression from TISSUES for MPHOSPH10 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with MPHOSPH10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MPHOSPH10 Gene

Orthologs for MPHOSPH10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MPHOSPH10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MPHOSPH10 34 33
  • 99.56 (n)
(Canis familiaris)
Mammalia MPHOSPH10 34 33
  • 87.95 (n)
(Bos Taurus)
Mammalia MPHOSPH10 34 33
  • 86.07 (n)
(Mus musculus)
Mammalia Mphosph10 16 34 33
  • 83.53 (n)
(Rattus norvegicus)
Mammalia Mphosph10 33
  • 82.44 (n)
(Monodelphis domestica)
Mammalia MPHOSPH10 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia MPHOSPH10 34
  • 44 (a)
(Gallus gallus)
Aves MPHOSPH10 34 33
  • 68.15 (n)
(Anolis carolinensis)
Reptilia MPHOSPH10 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mphosph10 33
  • 66.02 (n)
Str.16216 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398524 33
(Danio rerio)
Actinopterygii mphosph10 34 33 33
  • 61.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13097 34 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea Y75B8A.7 34 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPP10 36 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3443 34
  • 48 (a)
Species where no ortholog for MPHOSPH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPHOSPH10 Gene

Gene Tree for MPHOSPH10 (if available)
Gene Tree for MPHOSPH10 (if available)
Evolutionary constrained regions (ECRs) for MPHOSPH10: view image

Paralogs for MPHOSPH10 Gene

No data available for Paralogs for MPHOSPH10 Gene

Variants for MPHOSPH10 Gene

Sequence variations from dbSNP and Humsavar for MPHOSPH10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs201494468 uncertain-significance, Methylmalonic acidemia 71,130,255(+) G/A/C upstream_transcript_variant
rs1064795644 likely-benign, not specified 71,130,269(+) GC/TT upstream_transcript_variant
rs371660930 likely-benign, not specified 71,130,234(+) C/A upstream_transcript_variant
rs1000154373 -- 71,143,449(+) TTTTTTTT/TTTTTTT intron_variant
rs1000367572 -- 71,137,330(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MPHOSPH10 Gene

Variant ID Type Subtype PubMed ID
esv2662403 CNV deletion 23128226
esv2720185 CNV deletion 23290073
esv2759059 CNV loss 17122850
nsv1009014 CNV gain 25217958
nsv1146915 OTHER inversion 26484159
nsv2771 CNV deletion 18451855
nsv508148 CNV deletion 20534489
nsv834256 CNV gain 17160897
nsv963616 CNV duplication 23825009

Variation tolerance for MPHOSPH10 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.66; 99.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MPHOSPH10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MPHOSPH10 Gene

Disorders for MPHOSPH10 Gene

Additional Disease Information for MPHOSPH10

No disorders were found for MPHOSPH10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MPHOSPH10 Gene

Publications for MPHOSPH10 Gene

  1. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. (PMID: 9450966) Westendorf JM … Baserga SJ (Molecular biology of the cell 1998) 2 3 4 22 58
  2. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N … Westendorf JM (Molecular biology of the cell 1996) 2 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. (PMID: 12655004) Granneman S … Pruijn GJ (Nucleic acids research 2003) 3 4 58

Products for MPHOSPH10 Gene

Sources for MPHOSPH10 Gene

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