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Aliases for TXNDC9 Gene

Aliases for TXNDC9 Gene

  • Thioredoxin Domain Containing 9 2 3 5
  • Protein 1-4 3 4
  • APACD 3 4
  • ATP Binding Protein Associated With Cell Differentiation 3
  • ATP-Binding Protein Associated With Cell Differentiation 4
  • Thioredoxin Domain-Containing Protein 9 3
  • PHLP3 3

External Ids for TXNDC9 Gene

Previous GeneCards Identifiers for TXNDC9 Gene

  • GC02M099557
  • GC02M099394
  • GC02M099935
  • GC02M093700
  • GC02M099921

Summaries for TXNDC9 Gene

Entrez Gene Summary for TXNDC9 Gene

  • The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TXNDC9 Gene

TXNDC9 (Thioredoxin Domain Containing 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TXNDC9 Gene

  • Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.

Gene Wiki entry for TXNDC9 Gene

Additional gene information for TXNDC9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXNDC9 Gene

Genomics for TXNDC9 Gene

GeneHancer (GH) Regulatory Elements for TXNDC9 Gene

Promoters and enhancers for TXNDC9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J099334 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +3.7 3738 3.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 EIF5B TXNDC9 LOC550644 UNC50 MITD1 ENSG00000273306 TSGA10 REV1 LIPT1 LYG1
GH02J099430 Enhancer 0.5 ENCODE 11.2 -90.5 -90541 1.4 OSR2 ZSCAN21 GATA3 PRDM6 BCL11A ZFP37 TSGA10 EIF5B TXNDC9 REV1 MRPL30 LIPT1 LYG1 ENSG00000273306
GH02J099388 Enhancer 0.3 ENCODE 11.5 -49.0 -49004 1.5 FOS TSGA10 LYG1 TXNDC9 EIF5B REV1 ENSG00000273306
GH02J099403 Enhancer 0.8 ENCODE 0.2 -63.6 -63615 1.5 DMAP1 RAD21 RARA SLC30A9 ZNF614 SMAD5 ZBTB25 PPARG KAT8 SP1 ENSG00000273306 LYG1 REV1 TXNDC9
GH02J099323 Enhancer 0.3 ENCODE 0.4 +16.3 16312 1.4 FOS TSGA10 REV1 ENSG00000241962 MITD1 MRPL30 LIPT1 LYG1 PIR33754 EIF5B TXNDC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TXNDC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TXNDC9 gene promoter:
  • AREB6
  • Elk-1
  • IRF-2
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for TXNDC9 Gene

Genomic Locations for TXNDC9 Gene
21,721 bases
Minus strand
21,721 bases
Minus strand

Genomic View for TXNDC9 Gene

Genes around TXNDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXNDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXNDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXNDC9 Gene

Proteins for TXNDC9 Gene

  • Protein details for TXNDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B2R9G8
    • D3DVI4
    • Q53HG4
    • Q53RV8
    • Q6NSF5
    • Q8TB70
    • Q9BRU6

    Protein attributes for TXNDC9 Gene

    226 amino acids
    Molecular mass:
    26534 Da
    Quaternary structure:
    • Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.

    Alternative splice isoforms for TXNDC9 Gene


neXtProt entry for TXNDC9 Gene

Post-translational modifications for TXNDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXNDC9 Gene

No data available for DME Specific Peptides for TXNDC9 Gene

Domains & Families for TXNDC9 Gene

Gene Families for TXNDC9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TXNDC9 Gene

Suggested Antigen Peptide Sequences for TXNDC9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TXNDC9: view

No data available for UniProtKB/Swiss-Prot for TXNDC9 Gene

Function for TXNDC9 Gene

Molecular function for TXNDC9 Gene

UniProtKB/Swiss-Prot Function:
Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.

Gene Ontology (GO) - Molecular Function for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0008479 contributes_to queuine tRNA-ribosyltransferase activity IBA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with TXNDC9: view
genes like me logo Genes that share phenotypes with TXNDC9: view

Animal Model Products

miRNA for TXNDC9 Gene

miRTarBase miRNAs that target TXNDC9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXNDC9 Gene

Localization for TXNDC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXNDC9 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Co-localizes with beta-tubulin in the centrosome. {ECO:0000250 UniProtKB:Q9CQ79}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TXNDC9 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005813 centrosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TXNDC9: view

Pathways & Interactions for TXNDC9 Gene

SuperPathways for TXNDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXNDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008616 queuosine biosynthetic process IBA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with TXNDC9: view

No data available for Pathways by source and SIGNOR curated interactions for TXNDC9 Gene

Drugs & Compounds for TXNDC9 Gene

No Compound Related Data Available

Transcripts for TXNDC9 Gene

mRNA/cDNA for TXNDC9 Gene

Unigene Clusters for TXNDC9 Gene

Thioredoxin domain containing 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXNDC9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - - -

Relevant External Links for TXNDC9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXNDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TXNDC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TXNDC9 Gene

This gene is overexpressed in Breast (32.2) and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TXNDC9 Gene

Protein tissue co-expression partners for TXNDC9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TXNDC9 Gene:


SOURCE GeneReport for Unigene cluster for TXNDC9 Gene:


Evidence on tissue expression from TISSUES for TXNDC9 Gene

  • Nervous system(4.8)
  • Kidney(4.4)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with TXNDC9: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TXNDC9 Gene

Orthologs for TXNDC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TXNDC9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC9 34 33
  • 99.85 (n)
(Canis familiaris)
Mammalia TXNDC9 34 33
  • 93.46 (n)
(Bos Taurus)
Mammalia TXNDC9 34 33
  • 92.85 (n)
(Ornithorhynchus anatinus)
Mammalia TXNDC9 34
  • 92 (a)
(Monodelphis domestica)
Mammalia TXNDC9 34
  • 86 (a)
(Mus musculus)
Mammalia Txndc9 16 34 33
  • 85.54 (n)
(Rattus norvegicus)
Mammalia Txndc9 33
  • 85.24 (n)
(Gallus gallus)
Aves TXNDC9 34 33
  • 80.67 (n)
(Anolis carolinensis)
Reptilia TXNDC9 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txndc9 33
  • 79 (n)
Str.2720 33
African clawed frog
(Xenopus laevis)
Amphibia apacd-prov 33
(Danio rerio)
Actinopterygii txndc9 34 33
  • 70.68 (n)
wufb15e07 33
fruit fly
(Drosophila melanogaster)
Insecta CG4511 34 33
  • 56.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003485 33
  • 54.67 (n)
(Caenorhabditis elegans)
Secernentea tag-170 34 33
  • 52.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLP1 36 34
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TXND9 33
  • 57.95 (n)
(Oryza sativa)
Liliopsida Os08g0250700 33
  • 52.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4777 34
  • 58 (a)
Species where no ortholog for TXNDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXNDC9 Gene

Gene Tree for TXNDC9 (if available)
Gene Tree for TXNDC9 (if available)
Evolutionary constrained regions (ECRs) for TXNDC9: view image

Paralogs for TXNDC9 Gene Pseudogenes for TXNDC9 Gene

genes like me logo Genes that share paralogs with TXNDC9: view

No data available for Paralogs for TXNDC9 Gene

Variants for TXNDC9 Gene

Sequence variations from dbSNP and Humsavar for TXNDC9 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000014715 -- 99,320,235(-) T/C intron_variant
rs1000057524 -- 99,318,695(-) G/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000185159 -- 99,324,856(-) C/T intron_variant
rs1000215981 -- 99,325,050(-) T/C intron_variant
rs1000428311 -- 99,318,459(-) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TXNDC9 Gene

Variant ID Type Subtype PubMed ID
nsv524466 CNV loss 19592680

Variation tolerance for TXNDC9 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TXNDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXNDC9 Gene

Disorders for TXNDC9 Gene

Additional Disease Information for TXNDC9

No disorders were found for TXNDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TXNDC9 Gene

Publications for TXNDC9 Gene

  1. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. (PMID: 16415341) Stirling PC … Leroux MR (The Journal of biological chemistry 2006) 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TXNDC9 Gene

Sources for TXNDC9 Gene

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