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Aliases for RBM6 Gene

Aliases for RBM6 Gene

  • RNA Binding Motif Protein 6 2 3 5
  • Lung Cancer Antigen NY-LU-12 3 4
  • RNA-Binding Protein DEF-3 3 4
  • DEF3 3 4
  • Lung Cancer Protooncogene 11 3
  • RNA-Binding Motif Protein 6 4
  • RNA-Binding Protein 6 3
  • Protein G16 4
  • NY-LU-12 3
  • HLC-11 3
  • DEF-3 3
  • 3G2 3
  • G16 3

External Ids for RBM6 Gene

Previous GeneCards Identifiers for RBM6 Gene

  • GC03M049873
  • GC03M050042
  • GC03P049831
  • GC03P049936

Summaries for RBM6 Gene

GeneCards Summary for RBM6 Gene

RBM6 (RNA Binding Motif Protein 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM5.

UniProtKB/Swiss-Prot for RBM6 Gene

  • Specifically binds poly(G) RNA homopolymers in vitro.

Gene Wiki entry for RBM6 Gene

Additional gene information for RBM6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM6 Gene

Genomics for RBM6 Gene

GeneHancer (GH) Regulatory Elements for RBM6 Gene

Promoters and enhancers for RBM6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049939 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 706 +0.4 437 2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RBM6 NICN1 ENSG00000235236 RBM5 QRICH1 ENSG00000223343 P4HTM NAA80 WDR6 GC03P049762
GH03J050598 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.4 +666.5 666480 15 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CISH MAPKAPK3 RBM5 RBM6 TMEM115 HEMK1 RAD54L2 SEMA3F-AS1 C3orf18 DCAF1
GH03J049898 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.8 -37.3 -37306 9.2 HDGF PKNOX1 ARID4B IRF4 ZNF48 GLIS2 E2F8 ARID2 ZNF143 FOS MST1R GC03P049904 ENSG00000228008 RBM6 GMPPB IFRD2 SEMA3F MON1A APEH TUSC2
GH03J050319 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 50.4 +382.5 382546 5.2 HDGF CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 HYAL2 RBM6 RBM5 AMT SEMA3F-AS1 TMEM115 HYAL3 RHOA-IT1 RASSF1 HEMK1
GH03J049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.8 -594.0 -593957 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A USP4 AMT QRICH1 RBM6 RBM5 IP6K2 ATRIP USP19 WDR6 BSN-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM6 gene promoter:
  • Gfi-1
  • Tal-1beta
  • E47
  • AREB6
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4

Genomic Locations for RBM6 Gene

Genomic Locations for RBM6 Gene
160,039 bases
Plus strand
160,039 bases
Plus strand

Genomic View for RBM6 Gene

Genes around RBM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM6 Gene

Proteins for RBM6 Gene

  • Protein details for RBM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • B4E0G6
    • O60549
    • O75524
    • Q86SS3

    Protein attributes for RBM6 Gene

    1123 amino acids
    Molecular mass:
    128644 Da
    Quaternary structure:
    • May interact with FAM168B.

    Alternative splice isoforms for RBM6 Gene


neXtProt entry for RBM6 Gene

Post-translational modifications for RBM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM6 Gene

Domains & Families for RBM6 Gene

Gene Families for RBM6 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM6: view

No data available for UniProtKB/Swiss-Prot for RBM6 Gene

Function for RBM6 Gene

Molecular function for RBM6 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds poly(G) RNA homopolymers in vitro.
GENATLAS Biochemistry:
RNA binding protein 6,including two alternatively spliced long and short (truncated) isoforms with some homology with DXS8237E,located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E

Phenotypes From GWAS Catalog for RBM6 Gene

Gene Ontology (GO) - Molecular Function for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10352938
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBM6: view
genes like me logo Genes that share phenotypes with RBM6: view

Animal Model Products

CRISPR Products

miRNA for RBM6 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM6 Gene

Localization for RBM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM6 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
genes like me logo Genes that share ontologies with RBM6: view

Pathways & Interactions for RBM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 10352938
genes like me logo Genes that share ontologies with RBM6: view

No data available for Pathways by source and SIGNOR curated interactions for RBM6 Gene

Drugs & Compounds for RBM6 Gene

No Compound Related Data Available

Transcripts for RBM6 Gene

Unigene Clusters for RBM6 Gene

RNA binding motif protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - -
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -
SP11: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -

Relevant External Links for RBM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM6 Gene

Protein differential expression in normal tissues from HIPED for RBM6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5), Placenta (15.2), and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM6 Gene

Protein tissue co-expression partners for RBM6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM6 Gene:


SOURCE GeneReport for Unigene cluster for RBM6 Gene:


mRNA Expression by UniProt/SwissProt for RBM6 Gene:

Tissue specificity: Ubiquitous in adults.

Evidence on tissue expression from TISSUES for RBM6 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.4)
  • Intestine(3.6)
  • Pancreas(3.3)
  • Skin(2.9)
  • Heart(2.7)
  • Eye(2.5)
  • Spleen(2.5)
  • Stomach(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RBM6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM6 Gene

Orthologs for RBM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM6 34 33
  • 99.84 (n)
(Canis familiaris)
Mammalia RBM6 34 33
  • 92.69 (n)
(Bos Taurus)
Mammalia RBM6 34 33
  • 92.08 (n)
(Mus musculus)
Mammalia Rbm6 16 34 33
  • 89.86 (n)
(Rattus norvegicus)
Mammalia Rbm6 33
  • 89.37 (n)
(Monodelphis domestica)
Mammalia RBM6 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RBM6 34
  • 72 (a)
(Gallus gallus)
Aves RBM6 34 33
  • 68.47 (n)
(Anolis carolinensis)
Reptilia RBM6 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498473 33
  • 49.7 (n)
(Danio rerio)
Actinopterygii rbm6 34
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4896 34
  • 18 (a)
CG4887 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea T08B2.5 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for RBM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM6 Gene

Gene Tree for RBM6 (if available)
Gene Tree for RBM6 (if available)
Evolutionary constrained regions (ECRs) for RBM6: view image

Paralogs for RBM6 Gene

Paralogs for RBM6 Gene

genes like me logo Genes that share paralogs with RBM6: view

Variants for RBM6 Gene

Sequence variations from dbSNP and Humsavar for RBM6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs61731329 A non-small cell lung cancer cell line 49,968,483(+) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000004236 -- 50,057,145(+) G/T intron_variant
rs1000020590 -- 50,062,542(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000056651 -- 50,057,661(+) G/T intron_variant
rs1000073694 -- 50,071,490(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM6 Gene

Variant ID Type Subtype PubMed ID
esv1004636 CNV deletion 20482838
esv1163072 CNV insertion 17803354
esv2659342 CNV deletion 23128226
esv2725257 CNV deletion 23290073
esv3596134 CNV loss 21293372
esv3596135 CNV loss 21293372
nsv1012903 CNV gain 25217958
nsv1109512 CNV deletion 24896259
nsv1116989 CNV deletion 24896259
nsv515986 CNV loss 19592680
nsv590249 CNV loss 21841781
nsv820223 CNV loss 19587683
nsv822078 CNV loss 20364138
nsv834688 CNV loss 17160897
nsv834689 CNV loss 17160897
nsv834690 CNV loss 17160897

Variation tolerance for RBM6 Gene

Residual Variation Intolerance Score: 9.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM6 Gene

Disorders for RBM6 Gene

Additional Disease Information for RBM6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RBM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM6 Gene

Publications for RBM6 Gene

  1. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. (PMID: 10352938) Timmer T … Buys CH (European journal of human genetics : EJHG 1999) 2 3 4 58
  2. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. (PMID: 9500467) Güre AO … Chen YT (Cancer research 1998) 3 4 22 58
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
  4. RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours. (PMID: 17908320) Wang K … Sutherland LC (BMC genomics 2007) 3 22 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for RBM6 Gene

Sources for RBM6 Gene

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