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Aliases for CDK2 Gene

Aliases for CDK2 Gene

  • Cyclin Dependent Kinase 2 2 3 5
  • Cell Division Protein Kinase 2 3 4
  • P33 Protein Kinase 3 4
  • CDKN2 3 4
  • Cdc2-Related Protein Kinase 3
  • Cyclin-Dependent Kinase 2 3
  • EC 2.7.11.22 4
  • P33(CDK2) 3

External Ids for CDK2 Gene

Previous GeneCards Identifiers for CDK2 Gene

  • GC12M056216
  • GC12P056923
  • GC12P056077
  • GC12P054646
  • GC12P056360
  • GC12P053399

Summaries for CDK2 Gene

Entrez Gene Summary for CDK2 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

CIViC summary for CDK2 Gene

GeneCards Summary for CDK2 Gene

CDK2 (Cyclin Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include Breast Cancer and Retinal Cancer. Among its related pathways are Gene Expression and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK3.

UniProtKB/Swiss-Prot for CDK2 Gene

  • Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).

Tocris Summary for CDK2 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK2 Gene

Additional gene information for CDK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2 Gene

Genomics for CDK2 Gene

GeneHancer (GH) Regulatory Elements for CDK2 Gene

Promoters and enhancers for CDK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055965 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 661.7 +0.1 136 3.4 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B GLIS2 E2F8 PMEL CDK2 ENSG00000258554 BAZ2A RN7SL809P DNAJC14 ZC3H10 PYM1 RNU6-343P STAT2
GH12J056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.5 +75.2 75230 3.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS26 LOC105369780 BAZ2A RN7SL809P ZC3H10 STAT2 PAN2 CDK2 DNAJC14 ENSG00000258199
GH12J055715 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 41.4 -248.1 -248097 7.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RDH5 ITGA7 BLOC1S1 PIR46127 PIR49113 BAZ2A DNAJC14 RN7SL809P TMEM198B CDK2
GH12J056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 41.1 +256.1 256113 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 RNF41 NABP2 NEMP1 BAZ2A PAN2 DNAJC14 ZBTB39 RN7SL809P ZC3H10 PHC1P1
GH12J056298 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.1 +334.0 334041 4.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 ENSG00000257303 IL23A CS BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CDK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CDK2 gene promoter:
  • Sp1
  • C/EBPbeta

Genomic Locations for CDK2 Gene

Genomic Locations for CDK2 Gene
chr12:55,966,769-55,972,789
(GRCh38/hg38)
Size:
6,021 bases
Orientation:
Plus strand
chr12:56,360,553-56,366,568
(GRCh37/hg19)
Size:
6,016 bases
Orientation:
Plus strand

Genomic View for CDK2 Gene

Genes around CDK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2 Gene

Proteins for CDK2 Gene

  • Protein details for CDK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24941-CDK2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2
    Protein Accession:
    P24941
    Secondary Accessions:
    • A8K7C6
    • O75100

    Protein attributes for CDK2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33930 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC (PubMed:15611625). Interaction with SPDYA promotes kinase activation via a conformation change that alleviates obstruction of the substrate-binding cleft by the T-loop (PubMed:28666995). Found in a complex with both SPDYA and CDKN1B/KIP1 (PubMed:12972555, PubMed:28666995). Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63. Interacts with ANKRD17. Interacts with CEBPA (when phosphorylated) (PubMed:15107404). Forms a ternary complex with CCNA2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with cyclins A, B1, B3, D, or E (PubMed:10499802, PubMed:10884347, PubMed:12185076, PubMed:23781148). Interacts with CDK2AP2 (PubMed:23781148).

    Three dimensional structures from OCA and Proteopedia for CDK2 Gene

    Alternative splice isoforms for CDK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK2 Gene

Post-translational modifications for CDK2 Gene

  • Phosphorylated at Thr-160 by CDK7 in a CAK complex (PubMed:28666995). Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.
  • Nitrosylated after treatment with nitric oxide (DETA-NO).
  • Ubiquitination at Lys291, posLast=237237, Lys142, posLast=129129, Lys56, and Lys6
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CDK2 Gene

Domains & Families for CDK2 Gene

Gene Families for CDK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDK2 Gene

Suggested Antigen Peptide Sequences for CDK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24941

UniProtKB/Swiss-Prot:

CDK2_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK2: view

Function for CDK2 Gene

Molecular function for CDK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it (PubMed:1396589). Inhibited by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), AG-024322, N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine, pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic quinoxalin-2-one, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032 (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A (p21).
UniProtKB/Swiss-Prot Induction:
Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis.
GENATLAS Biochemistry:
cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with cyclin E for the regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX and BCL2,putative checkpoint between cell cycle and cell death pathway

Enzyme Numbers (IUBMB) for CDK2 Gene

Phenotypes From GWAS Catalog for CDK2 Gene

Gene Ontology (GO) - Molecular Function for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IGI,TAS --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 2227411
genes like me logo Genes that share ontologies with CDK2: view
genes like me logo Genes that share phenotypes with CDK2: view

Animal Models for CDK2 Gene

MGI Knock Outs for CDK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK2

miRNA for CDK2 Gene

miRTarBase miRNAs that target CDK2

Clone Products

  • Addgene plasmids for CDK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK2 Gene

Localization for CDK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endosome 5
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0000781 chromosome, telomeric region IEA --
GO:0000793 condensed chromosome IEA --
GO:0000805 X chromosome IEA --
GO:0000806 Y chromosome IEA --
genes like me logo Genes that share ontologies with CDK2: view

Pathways & Interactions for CDK2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 DNA Double-Strand Break Repair
3 Cyclins and Cell Cycle Regulation
4 E2F mediated regulation of DNA replication
5 Cell cycle Cell cycle (generic schema)
.01
genes like me logo Genes that share pathways with CDK2: view

Gene Ontology (GO) - Biological Process for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS,NAS --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006260 DNA replication TAS 19238148
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CDK2: view

Drugs & Compounds for CDK2 Gene

(278) Drugs for CDK2 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Deferasirox Approved, Investigational Pharma Oral iron chelator 93
Bosulif Approved September 2012 Pharma 0
Alvocidib Experimental, Investigational Pharma inhibitor, Target Pan-cdk inhibitor, Kinase Inhibitors 60
Olomoucine Experimental Pharma Target, inhibitor Cyclin-dependent kinase inhibitor 0

(65) Additional Compounds for CDK2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-CR8
294646-77-8
Arcyriaflavin A
118458-54-1

(5) Tocris Compounds for CDK2 Gene

Compound Action Cas Number
(R)-CR8 Dual cdk1/cdk5 inhibitor; also inhibits CK1 294646-77-8
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 118458-54-1
AZD 5438 Potent cyclin-dependent kinase (cdk) 1, 2 and 9 inhibitor 602306-29-6
Olomoucine Cyclin-dependent kinase inhibitor 101622-51-9
SU 9516 Potent cdk2 inhibitor 377090-84-1
genes like me logo Genes that share compounds with CDK2: view

Transcripts for CDK2 Gene

mRNA/cDNA for CDK2 Gene

Unigene Clusters for CDK2 Gene

Cyclin-dependent kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for CDK2

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - - -

Relevant External Links for CDK2 Gene

GeneLoc Exon Structure for
CDK2
ECgene alternative splicing isoforms for
CDK2

Expression for CDK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK2 Gene

This gene is overexpressed in Breast (12.5), Peripheral blood mononuclear cells (10.7), Lymph node (9.2), and Fetal gut (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDK2 Gene



Protein tissue co-expression partners for CDK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK2 Gene:

CDK2

SOURCE GeneReport for Unigene cluster for CDK2 Gene:

Hs.19192

Evidence on tissue expression from TISSUES for CDK2 Gene

  • Skin(4.1)
  • Nervous system(2.9)
  • Intestine(2.8)
  • Liver(2.7)
  • Lung(2.7)
  • Blood(2.5)
  • Muscle(2.5)
  • Bone marrow(2.3)
  • Kidney(2.3)
  • Heart(2.1)
  • Lymph node(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CDK2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK2 Gene

Orthologs for CDK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK2 34 33
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CDK2 34 33
  • 93.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CDK2 34 33
  • 93.29 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk2 16 34 33
  • 92.51 (n)
rat
(Rattus norvegicus)
Mammalia Cdk2 33
  • 91.5 (n)
chicken
(Gallus gallus)
Aves CDK2 34 33
  • 79.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK2 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk2 33
  • 77.36 (n)
Str.2871 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4227 33
zebrafish
(Danio rerio)
Actinopterygii cdk2 34 33
  • 75.84 (n)
OneToOne
Dr.17883 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9226 33
fruit fly
(Drosophila melanogaster)
Insecta cdc2 35
  • 64 (a)
cdc2c 34 35 33
  • 62.81 (n)
OneToMany
Cdk4 35
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004579 33
  • 60.94 (n)
worm
(Caenorhabditis elegans)
Secernentea cdk-1 35
  • 60 (a)
cdk-2 34
  • 40 (a)
ManyToMany
cdk-4