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Aliases for EBI3 Gene

Aliases for EBI3 Gene

  • Epstein-Barr Virus Induced 3 2 3 5
  • Epstein-Barr Virus-Induced Gene 3 Protein 3 4
  • EBV-Induced Gene 3 Protein 3 4
  • IL-27 Subunit Beta 3 4
  • IL27 Subunit 2 3
  • IL35 Subunit 2 3
  • IL-27B 3 4
  • IL27B 3 4
  • Epstein-Barr Virus Induced Gene 3 3
  • Interleukin-27 Subunit Beta 3
  • Cytokine Receptor 3
  • IL35B 3

External Ids for EBI3 Gene

Previous GeneCards Identifiers for EBI3 Gene

  • GC19P004322
  • GC19P004169
  • GC19P004180
  • GC19P003992

Summaries for EBI3 Gene

Entrez Gene Summary for EBI3 Gene

  • This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

GeneCards Summary for EBI3 Gene

EBI3 (Epstein-Barr Virus Induced 3) is a Protein Coding gene. Diseases associated with EBI3 include Inflammatory Bowel Disease. Among its related pathways are Interleukin-6 family signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-27 receptor binding. An important paralog of this gene is CNTFR.

UniProtKB/Swiss-Prot for EBI3 Gene

  • Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

Gene Wiki entry for EBI3 Gene

Additional gene information for EBI3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EBI3 Gene

Genomics for EBI3 Gene

GeneHancer (GH) Regulatory Elements for EBI3 Gene

Promoters and enhancers for EBI3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004227 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +0.1 144 4.2 HDGF PKNOX1 SMAD1 YBX1 ZNF2 ZNF48 ZNF121 GLIS2 ARID2 ZNF207 EBI3 CACTIN CACTIN-AS1 ENSG00000267030 YJU2 ENSG00000267769 APBA3 KDM4B ENSG00000267138 DPP9-AS1
GH19J004204 Enhancer 1.1 Ensembl ENCODE 12.4 -24.4 -24396 0.9 PKNOX1 RB1 THRB ZSCAN9 RAD21 RFX5 SLC30A9 GTF3C2 TCF12 ZNF614 YJU2 DPP9-AS1 ENSG00000267030 APBA3 SIRT6 ANKRD24 CREB3L3 ENSG00000267769 EBI3 CACTIN-AS1
GH19J004359 Enhancer 0.8 ENCODE dbSUPER 11.8 +131.9 131917 3.5 PTBP1 ZIC2 HIC1 ZFHX2 GLIS2 POLR2A GLIS1 PATZ1 RBM22 MLLT1 ENSG00000267769 CHAF1A UBXN6 SH3GL1 TMIGD2 FSD1 YJU2 EBI3 ENSG00000269318 ENSG00000267980
GH19J004208 Enhancer 0.7 ENCODE 12.7 -20.5 -20543 1.4 BCOR ELF3 CTCF PTBP1 SREBF2 ZMYM3 KLF14 RAD21 ADNP ZNF143 GC19P004210 YJU2 EBI3 SIRT6 ANKRD24 CREB3L3 SNORD37 TMIGD2 FSD1 GC19M004225
GH19J004207 Enhancer 0.6 ENCODE 12.7 -22.0 -21959 0.1 BCOR CTCF PTBP1 ZNF280D ZMYM3 RAD21 ZNF143 ZFP91 ZFP36 SMC3 GC19P004210 SIRT6 ANKRD24 EBI3 CREB3L3 YJU2 SNORD37 TMIGD2 FSD1 GC19P004195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EBI3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EBI3 gene promoter:
  • Lmo2
  • YY1
  • AP-4
  • c-Myb
  • STAT5A
  • Arnt
  • CP2
  • HEN1
  • AREB6
  • MZF-1

Genomic Locations for EBI3 Gene

Genomic Locations for EBI3 Gene
chr19:4,229,302-4,237,542
(GRCh38/hg38)
Size:
8,241 bases
Orientation:
Plus strand
chr19:4,229,495-4,237,528
(GRCh37/hg19)
Size:
8,034 bases
Orientation:
Plus strand

Genomic View for EBI3 Gene

Genes around EBI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EBI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EBI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EBI3 Gene

Proteins for EBI3 Gene

  • Protein details for EBI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14213-IL27B_HUMAN
    Recommended name:
    Interleukin-27 subunit beta
    Protein Accession:
    Q14213
    Secondary Accessions:
    • A0N0N2
    • O75269

    Protein attributes for EBI3 Gene

    Size:
    229 amino acids
    Molecular mass:
    25396 Da
    Quaternary structure:
    • Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.

neXtProt entry for EBI3 Gene

Post-translational modifications for EBI3 Gene

  • Glycosylation at isoforms=105 and Asn55

Other Protein References for EBI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EBI3 Gene

Domains & Families for EBI3 Gene

Protein Domains for EBI3 Gene

Suggested Antigen Peptide Sequences for EBI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14213

UniProtKB/Swiss-Prot:

IL27B_HUMAN :
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
Family:
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
genes like me logo Genes that share domains with EBI3: view

Function for EBI3 Gene

Molecular function for EBI3 Gene

UniProtKB/Swiss-Prot Function:
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).

Gene Ontology (GO) - Molecular Function for EBI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IPI 9342359
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 9342359
GO:0045523 interleukin-27 receptor binding IEA --
genes like me logo Genes that share ontologies with EBI3: view
genes like me logo Genes that share phenotypes with EBI3: view

Animal Models for EBI3 Gene

MGI Knock Outs for EBI3:

Animal Model Products

  • Taconic Biosciences Mouse Models for EBI3

Clone Products

  • Addgene plasmids for EBI3
  • R&D Systems cDNA Clones for EBI3 (IL-27/IL-35 EBI3 Subunit)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EBI3 Gene

Localization for EBI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EBI3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EBI3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for EBI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005886 plasma membrane TAS 8551575
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EBI3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EBI3 Gene

Pathways & Interactions for EBI3 Gene

genes like me logo Genes that share pathways with EBI3: view

Pathways by source for EBI3 Gene

Gene Ontology (GO) - Biological Process for EBI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response TAS 8551575
GO:0010469 regulation of signaling receptor activity IEA --
GO:0042088 T-helper 1 type immune response TAS 14743498
GO:0042098 T cell proliferation IEA --
GO:0045078 positive regulation of interferon-gamma biosynthetic process TAS 14743498
genes like me logo Genes that share ontologies with EBI3: view

No data available for SIGNOR curated interactions for EBI3 Gene

Drugs & Compounds for EBI3 Gene

No Compound Related Data Available

Transcripts for EBI3 Gene

mRNA/cDNA for EBI3 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(187) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EBI3 Gene

Epstein-Barr virus induced 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for EBI3
  • R&D Systems cDNA Clones for EBI3 (IL-27/IL-35 EBI3 Subunit)

Alternative Splicing Database (ASD) splice patterns (SP) for EBI3 Gene

No ASD Table

Relevant External Links for EBI3 Gene

GeneLoc Exon Structure for
EBI3
ECgene alternative splicing isoforms for
EBI3

Expression for EBI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EBI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EBI3 Gene

This gene is overexpressed in Spleen (x4.9).

Protein differential expression in normal tissues from HIPED for EBI3 Gene

This gene is overexpressed in Placenta (59.3) and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EBI3 Gene



Protein tissue co-expression partners for EBI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of EBI3 Gene:

EBI3

SOURCE GeneReport for Unigene cluster for EBI3 Gene:

Hs.501452

Evidence on tissue expression from TISSUES for EBI3 Gene

  • Pancreas(4.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with EBI3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EBI3 Gene

Orthologs for EBI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EBI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EBI3 34 33
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EBI3 34 33
  • 79.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EBI3 34 33
  • 79.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ebi3 16 34 33
  • 72.75 (n)
rat
(Rattus norvegicus)
Mammalia Ebi3 33
  • 72.02 (n)
oppossum
(Monodelphis domestica)
Mammalia EBI3 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EBI3 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EBI3 34
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ebi3 33
  • 50.42 (n)
zebrafish
(Danio rerio)
Actinopterygii ebi3 34 33
  • 44.91 (n)
OneToOne
Species where no ortholog for EBI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EBI3 Gene

ENSEMBL:
Gene Tree for EBI3 (if available)
TreeFam:
Gene Tree for EBI3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EBI3: view image

Paralogs for EBI3 Gene

Paralogs for EBI3 Gene

genes like me logo Genes that share paralogs with EBI3: view

Variants for EBI3 Gene

Sequence variations from dbSNP and Humsavar for EBI3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000037504 -- 4,234,193(+) G/A intron_variant
rs1000097068 -- 4,237,335(+) C/A 3_prime_UTR_variant
rs1000180347 -- 4,229,970(+) G/A intron_variant
rs1000636688 -- 4,233,083(+) G/A intron_variant
rs1000691685 -- 4,232,115(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EBI3 Gene

Variant ID Type Subtype PubMed ID
esv2717997 CNV deletion 23290073
esv2717998 CNV deletion 23290073
esv2717999 CNV deletion 23290073
nsv1152398 CNV duplication 26484159
nsv578442 CNV loss 21841781
nsv833716 CNV loss 17160897
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for EBI3 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EBI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EBI3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EBI3 Gene

Disorders for EBI3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EBI3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards
Search EBI3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EBI3

genes like me logo Genes that share disorders with EBI3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EBI3 Gene

Publications for EBI3 Gene

  1. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. (PMID: 9342359) Devergne O … Kieff E (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 22 58
  2. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. (PMID: 8551575) Devergne O … Birkenbach M (Journal of virology 1996) 2 3 4 58
  3. Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. (PMID: 19556516) Kempe S … Wirth T (The American journal of pathology 2009) 3 22 58
  4. IL27: its roles in the induction and inhibition of inflammation. (PMID: 18784808) Carl JW … Bai XF (International journal of clinical and experimental pathology 2008) 3 22 58
  5. Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor. (PMID: 18336908) Poleganov MA … Mühl H (Molecular immunology 2008) 3 22 58

Products for EBI3 Gene

Sources for EBI3 Gene

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