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Aliases for TSPAN3 Gene

Aliases for TSPAN3 Gene

  • Tetraspanin 3 2 3 5
  • Transmembrane 4 Superfamily Member 8 2 3 4
  • Tetraspanin TM4-A 3 4
  • TM4SF8 3 4
  • Tetraspan TM4SF 3
  • Tetraspanin-3 3
  • Tetraspan 3 3
  • TSPAN-3 3
  • Tspan-3 4
  • TM4-A 3

External Ids for TSPAN3 Gene

Previous HGNC Symbols for TSPAN3 Gene

  • TM4SF8

Previous GeneCards Identifiers for TSPAN3 Gene

  • GC15M075126
  • GC15M075127
  • GC15M077336
  • GC15M054093

Summaries for TSPAN3 Gene

Entrez Gene Summary for TSPAN3 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

GeneCards Summary for TSPAN3 Gene

TSPAN3 (Tetraspanin 3) is a Protein Coding gene. An important paralog of this gene is TSPAN7.

UniProtKB/Swiss-Prot for TSPAN3 Gene

  • Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Gene Wiki entry for TSPAN3 Gene

Additional gene information for TSPAN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN3 Gene

Genomics for TSPAN3 Gene

GeneHancer (GH) Regulatory Elements for TSPAN3 Gene

Promoters and enhancers for TSPAN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J077063 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 669.1 +16.4 16443 8.5 HDGF PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 TSPAN3 ENSG00000269951 PSTPIP1 LOC101929457 ENSG00000278991
GH15J077083 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 664.5 -0.2 -194 1.5 PKNOX1 TFAP4 USF1 MAX EBF1 RFX5 HIC1 ZNF335 GLIS2 POLR2A TSPAN3 PIR41987
GH15J077085 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.4 -1410 0.2 MEIS2 PKNOX1 JUN CEBPG IRF4 FOSL1 ZNF316 FOSL2 NFE2 FOS TSPAN3 PIR41987
GH15J076993 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.2 +87.2 87165 7.4 HDGF PKNOX1 FOXA2 STAT5A BATF IRF4 SCRT2 ATF7 RCOR1 FOS PSTPIP1 SCAPER TSPAN3 ETFA ENSG00000269951 ENSG00000259652
GH15J076987 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +95.4 95383 2 PKNOX1 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ZNF207 ATF7 ETV6 TSPAN3 SCAPER ISL2 PSTPIP1 KRT8P23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN3 gene promoter:
  • Nkx2-5
  • C/EBPalpha
  • IRF-7A
  • MZF-1
  • GATA-1
  • Evi-1
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a

Genomic Locations for TSPAN3 Gene

Genomic Locations for TSPAN3 Gene
42,581 bases
Minus strand
39,968 bases
Minus strand

Genomic View for TSPAN3 Gene

Genes around TSPAN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN3 Gene

Proteins for TSPAN3 Gene

  • Protein details for TSPAN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NEH4
    • B3KQQ2
    • B4DP19
    • Q9BW22
    • Q9NVX9

    Protein attributes for TSPAN3 Gene

    253 amino acids
    Molecular mass:
    28018 Da
    Quaternary structure:
    • Interacts with claudin-11/CLDN11 and integrins.

    Alternative splice isoforms for TSPAN3 Gene


neXtProt entry for TSPAN3 Gene

Post-translational modifications for TSPAN3 Gene

  • Ubiquitination at posLast=124124
  • Glycosylation at posLast=183183, posLast=167167, isoforms=2, 3152, and isoforms=2, 3127
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TSN3_HUMAN (710)

No data available for DME Specific Peptides for TSPAN3 Gene

Domains & Families for TSPAN3 Gene

Gene Families for TSPAN3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN3: view

Function for TSPAN3 Gene

Molecular function for TSPAN3 Gene

UniProtKB/Swiss-Prot Function:
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Phenotypes From GWAS Catalog for TSPAN3 Gene

Gene Ontology (GO) - Molecular Function for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSPAN3: view
genes like me logo Genes that share phenotypes with TSPAN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN3

CRISPR Products

miRNA for TSPAN3 Gene

miRTarBase miRNAs that target TSPAN3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN3 Gene

Localization for TSPAN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
golgi apparatus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with TSPAN3: view

Pathways & Interactions for TSPAN3 Gene

SuperPathways for TSPAN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TSPAN3: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN3 Gene

Drugs & Compounds for TSPAN3 Gene

No Compound Related Data Available

Transcripts for TSPAN3 Gene

mRNA/cDNA for TSPAN3 Gene

Unigene Clusters for TSPAN3 Gene

Tetraspanin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - -
SP3: - -
SP5: - -

Relevant External Links for TSPAN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN3 Gene

This gene is overexpressed in Nasal epithelium (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN3 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN3 Gene:


Evidence on tissue expression from TISSUES for TSPAN3 Gene

  • Intestine(4.9)
  • Nervous system(4.9)
  • Skin(4.7)
  • Muscle(4.4)
  • Eye(2.9)
  • Lung(2.9)
  • Gall bladder(2.1)
  • Kidney(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with TSPAN3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN3 Gene

Orthologs for TSPAN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSPAN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN3 34 33
  • 99.74 (n)
(Ornithorhynchus anatinus)
Mammalia TSPAN3 34
  • 94 (a)
(Canis familiaris)
Mammalia TSPAN3 34
  • 94 (a)
(Monodelphis domestica)
Mammalia TSPAN3 34
  • 94 (a)
(Bos Taurus)
Mammalia TSPAN3 34 33
  • 93.28 (n)
(Mus musculus)
Mammalia Tspan3 16 34 33
  • 90.91 (n)
(Rattus norvegicus)
Mammalia Tspan3 33
  • 89.99 (n)
(Gallus gallus)
Aves TSPAN3 34 33
  • 82.06 (n)
(Anolis carolinensis)
Reptilia TSPAN3 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan3 33
  • 76.42 (n)
Str.5967 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23773 33
(Danio rerio)
Actinopterygii tspan3b 34
  • 77 (a)
tspan3a 34 33
  • 76.42 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1062 33
Species where no ortholog for TSPAN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN3 Gene

Gene Tree for TSPAN3 (if available)
Gene Tree for TSPAN3 (if available)
Evolutionary constrained regions (ECRs) for TSPAN3: view image

Paralogs for TSPAN3 Gene

(12) SIMAP similar genes for TSPAN3 Gene using alignment to 4 proteins:

  • L8E893_HUMAN
genes like me logo Genes that share paralogs with TSPAN3: view

Variants for TSPAN3 Gene

Sequence variations from dbSNP and Humsavar for TSPAN3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000077993 -- 77,047,527(-) T/G intron_variant
rs1000132806 -- 77,069,634(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000152616 -- 77,047,754(-) T/C intron_variant
rs1000237240 -- 77,063,478(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000391140 -- 77,059,715(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN3 Gene

Variant ID Type Subtype PubMed ID
esv2749898 CNV deletion 23290073
esv2760041 CNV gain 17122850
esv3336267 CNV duplication 20981092
esv3552703 CNV deletion 23714750
nsv1040852 CNV gain 25217958
nsv1048833 CNV gain 25217958
nsv1116463 OTHER inversion 24896259
nsv1622 CNV insertion 18451855
nsv509576 CNV insertion 20534489
nsv511547 CNV loss 21212237
nsv517068 CNV gain+loss 19592680
nsv833058 CNV loss 17160897

Variation tolerance for TSPAN3 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN3 Gene

Disorders for TSPAN3 Gene

Additional Disease Information for TSPAN3

No disorders were found for TSPAN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN3 Gene

Publications for TSPAN3 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd SC … Levy S (Biochimica et biophysica acta 1998) 3 4 58
  5. Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. (PMID: 27818272) Seipold L … Saftig P (Biochimica et biophysica acta 2017) 3 58

Products for TSPAN3 Gene

Sources for TSPAN3 Gene

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