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Aliases for ARPC3 Gene

Aliases for ARPC3 Gene

  • Actin Related Protein 2/3 Complex Subunit 3 2 3 5
  • Arp2/3 Complex 21 KDa Subunit 3 4
  • ARC21 3 4
  • Actin Related Protein 2/3 Complex, Subunit 3 (21 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 3, 21kDa 3
  • Actin Related Protein 2/3 Complex Subunit 3, 21kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 3 3
  • ARP2/3 Protein Complex Subunit P21 3
  • P21-Arc 3
  • P21-ARC 4

External Ids for ARPC3 Gene

Previous GeneCards Identifiers for ARPC3 Gene

  • GC12M109896
  • GC12M110668
  • GC12M110714
  • GC12M109284
  • GC12M109335
  • GC12M110872
  • GC12M107890

Summaries for ARPC3 Gene

Entrez Gene Summary for ARPC3 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for ARPC3 Gene

ARPC3 (Actin Related Protein 2/3 Complex Subunit 3) is a Protein Coding gene. Diseases associated with ARPC3 include Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are Developmental Biology and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for ARPC3 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC3 Gene

Additional gene information for ARPC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC3 Gene

Genomics for ARPC3 Gene

GeneHancer (GH) Regulatory Elements for ARPC3 Gene

Promoters and enhancers for ARPC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J110449 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 235 2.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ARPC3 GPN3 GLTP FAM216A ENSG00000258210
GH12J110279 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.9 +167.6 167602 5.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ATP2A2 GPN3 ARPC3 ANAPC7 RNU4-32P IFT81 UBE3B GC12M110365 RN7SL769P
GH12J110466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.8 -17.9 -17896 3.8 CLOCK ZFP64 DMAP1 YBX1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GPN3 FAM216A ARPC3 RNU4-32P IFT81 HSPA8P14 ENSG00000257268 UBE3B PPP1CC RPL31P49
GH12J110499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.6 -50.6 -50616 4 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ENSG00000278993 RAD9B VPS29 IFT81 ARPC3 FAM216A ENSG00000257268 ANAPC7 GPN3 RNU4-32P
GH12J110123 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.8 +325.8 325831 1.7 ARID4B SIN3A DMAP1 YY1 E2F8 KLF13 SP3 SP5 MXD4 REST IFT81 ARPC3 C12orf76 UBE3B TCTN1 FAM216A GC12P110223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARPC3 gene promoter:
  • ATF6
  • E2F-1
  • E2F
  • c-Ets-1
  • AP-2gamma
  • AP-4
  • MRF-2
  • GR
  • GR-alpha
  • NRSF form 1

Genomic Locations for ARPC3 Gene

Genomic Locations for ARPC3 Gene
chr12:110,434,825-110,450,422
(GRCh38/hg38)
Size:
15,598 bases
Orientation:
Minus strand
chr12:110,872,630-110,888,227
(GRCh37/hg19)
Size:
15,598 bases
Orientation:
Minus strand

Genomic View for ARPC3 Gene

Genes around ARPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC3 Gene

Proteins for ARPC3 Gene

  • Protein details for ARPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15145-ARPC3_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 3
    Protein Accession:
    O15145
    Secondary Accessions:
    • O00554

    Protein attributes for ARPC3 Gene

    Size:
    178 amino acids
    Molecular mass:
    20547 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC3 Gene

Post-translational modifications for ARPC3 Gene

  • Ubiquitination at Lys171, Lys158, Lys56, and posLast=1414
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC3 Gene

No data available for DME Specific Peptides for ARPC3 Gene

Domains & Families for ARPC3 Gene

Gene Families for ARPC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARPC3 Gene

Graphical View of Domain Structure for InterPro Entry

O15145

UniProtKB/Swiss-Prot:

ARPC3_HUMAN :
  • Belongs to the ARPC3 family.
Family:
  • Belongs to the ARPC3 family.
genes like me logo Genes that share domains with ARPC3: view

Function for ARPC3 Gene

Molecular function for ARPC3 Gene

UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
GENATLAS Biochemistry:
actin related protein 2/3 complex,subunit 3 (21kDa),localized to the lamellipodia of stationary and locomoting fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion

Phenotypes From GWAS Catalog for ARPC3 Gene

Gene Ontology (GO) - Molecular Function for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC3: view
genes like me logo Genes that share phenotypes with ARPC3: view

Animal Models for ARPC3 Gene

MGI Knock Outs for ARPC3:
  • Arpc3 Arpc3<tm1Jtak>
  • Arpc3 Arpc3<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

  • Addgene plasmids for ARPC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC3 Gene

Localization for ARPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC3 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC3 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IDA,IEA 11741539
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with ARPC3: view

Pathways & Interactions for ARPC3 Gene

genes like me logo Genes that share pathways with ARPC3: view

Gene Ontology (GO) - Biological Process for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA,IEA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with ARPC3: view

No data available for SIGNOR curated interactions for ARPC3 Gene

Drugs & Compounds for ARPC3 Gene

(3) Drugs for ARPC3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
CK-636 Pharma Arp2/3 complex inhibitor 0
genes like me logo Genes that share compounds with ARPC3: view

Transcripts for ARPC3 Gene

mRNA/cDNA for ARPC3 Gene

Unigene Clusters for ARPC3 Gene

Actin related protein 2/3 complex, subunit 3, 21kDa:
Representative Sequences:

Clone Products

  • Addgene plasmids for ARPC3

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for ARPC3 Gene

GeneLoc Exon Structure for
ARPC3
ECgene alternative splicing isoforms for
ARPC3

Expression for ARPC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC3 Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for ARPC3 Gene

This gene is overexpressed in Tlymphocyte (6.9) and Spleen (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARPC3 Gene



Protein tissue co-expression partners for ARPC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC3 Gene:

ARPC3

SOURCE GeneReport for Unigene cluster for ARPC3 Gene:

Hs.524741

Evidence on tissue expression from TISSUES for ARPC3 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Liver(4.4)
  • Skin(4.4)
  • Pancreas(3.9)
  • Lung(3.7)
  • Spleen(2.7)
  • Intestine(2.6)
  • Heart(2.3)
  • Kidney(2.3)
  • Bone marrow(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with ARPC3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC3 Gene

Orthologs for ARPC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC3 34 33
  • 99.63 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC3 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC3 34 33
  • 94.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC3 34 33
  • 94.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc3 33
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Arpc3 16 34 33
  • 86.7 (n)
chicken
(Gallus gallus)
Aves ARPC3 34 33
  • 83.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPC3 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc3 33
  • 79.03 (n)
Str.10867 33
zebrafish
(Danio rerio)
Actinopterygii arpc3 34 33
  • 78.46 (n)
OneToOne
gng3 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8941 33
fruit fly
(Drosophila melanogaster)
Insecta Arpc3A 34 33
  • 62.34 (n)
OneToMany
Arpc3B 34
  • 61 (a)
OneToMany
CG8936 35
  • 60 (a)
CG4560 35
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001712 33
  • 60.26 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-5 34 33
  • 59.05 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07821g 33
  • 54.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC18 36 34 33
  • 52.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR584C 33
  • 51.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC3 33
  • 53.61 (n)
rice
(Oryza sativa)
Liliopsida Os02g0235000 33
  • 52.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc3 33
  • 55.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09572 33
  • 52.6 (n)
Species where no ortholog for ARPC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC3 Gene

ENSEMBL:
Gene Tree for ARPC3 (if available)
TreeFam:
Gene Tree for ARPC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC3: view image

Paralogs for ARPC3 Gene

genes like me logo Genes that share paralogs with ARPC3: view

No data available for Paralogs for ARPC3 Gene

Variants for ARPC3 Gene

Sequence variations from dbSNP and Humsavar for ARPC3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000120781 -- 110,442,375(-) A/C/T intron_variant
rs1000137416 -- 110,447,591(-) G/C intron_variant
rs1000210057 -- 110,447,448(-) G/T intron_variant
rs1000485991 -- 110,441,065(-) G/C intron_variant
rs1000535968 -- 110,445,676(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC3 Gene

Variant ID Type Subtype PubMed ID
nsv976651 CNV duplication 23825009

Variation tolerance for ARPC3 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC3 Gene

Human Gene Mutation Database (HGMD)
ARPC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC3 Gene

Disorders for ARPC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARPC3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
myasthenic syndrome, congenital, 6, presynaptic
  • cms6
- elite association - COSMIC cancer census association via MalaCards
Search ARPC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARPC3

genes like me logo Genes that share disorders with ARPC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC3 Gene

Publications for ARPC3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4 58
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky LM … Segal AW (The Biochemical journal 1997) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H … Welch MD (Molecular cell 2001) 3 4 58

Products for ARPC3 Gene

Sources for ARPC3 Gene

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