Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SCAMP3 Gene

Aliases for SCAMP3 Gene

  • Secretory Carrier Membrane Protein 3 2 3 4 5
  • Propin 1 2 3
  • C1orf3 3 4
  • Secretory Carrier-Associated Membrane Protein 3 3
  • PROPIN1 4

External Ids for SCAMP3 Gene

Previous HGNC Symbols for SCAMP3 Gene

  • C1orf3

Previous GeneCards Identifiers for SCAMP3 Gene

  • GC01M153083
  • GC01M150966
  • GC01M152003
  • GC01M152442
  • GC01M152038
  • GC01M153494
  • GC01M155225
  • GC01M126588

Summaries for SCAMP3 Gene

Entrez Gene Summary for SCAMP3 Gene

  • This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for SCAMP3 Gene

SCAMP3 (Secretory Carrier Membrane Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is SCAMP1.

UniProtKB/Swiss-Prot for SCAMP3 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP3 Gene

Additional gene information for SCAMP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAMP3 Gene

Genomics for SCAMP3 Gene

GeneHancer (GH) Regulatory Elements for SCAMP3 Gene

Promoters and enhancers for SCAMP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155260 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 394 3 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 SCAMP3 CLK2 KHDC4 ENSG00000271267 GON4L GBA RUSC1-AS1 MSTO2P LOC101928120 THBS3
GH01J154998 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +258.0 257983 11.3 CLOCK MLX YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 ZBTB7B GON4L CLK2 UBAP2L KHDC4 ENSG00000271267 THBS3 RUSC1-AS1 SHC1 MSTO1
GH01J155206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +53.7 53747 4.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 THBS3 MTX1 FAM189B SCAMP3 TRIM46 KRTCAP2 LMNA DAP3 POU5F1P4 LOC105371450
GH01J154606 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +654.0 653969 4.1 HDGF ARNT ARID4B NEUROD1 SIN3A FEZF1 YBX1 ZNF2 IRF4 YY1 ADAR CLK2 CHTOP ILF2 ENSG00000271267 RUSC1-AS1 UBAP2L ASH1L-AS1 FLAD1 CRTC2
GH01J155856 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -596.5 -596516 5.7 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 GON4L SYT11 KHDC4 ENSG00000271267 RRNAD1 CLK2 THBS3 DAP3 FLAD1 PYGO2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCAMP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCAMP3 gene promoter:
  • POU2F1
  • PPAR-gamma2
  • PPAR-gamma1
  • Bach2
  • POU2F1a
  • Arnt
  • Tal-1beta
  • ITF-2
  • MAZR
  • AhR

Genomic Locations for SCAMP3 Gene

Genomic Locations for SCAMP3 Gene
6,456 bases
Minus strand
6,452 bases
Minus strand

Genomic View for SCAMP3 Gene

Genes around SCAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP3 Gene

Proteins for SCAMP3 Gene

  • Protein details for SCAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secretory carrier-associated membrane protein 3
    Protein Accession:
    Secondary Accessions:
    • A9Z1W6
    • B1AVS6
    • O15128
    • Q96FR8
    • Q9BPY0

    Protein attributes for SCAMP3 Gene

    347 amino acids
    Molecular mass:
    38287 Da
    Quaternary structure:
    • Interacts with NEDD4, NEDD4L and TSG101. Interacts with RNF126.

    Alternative splice isoforms for SCAMP3 Gene


neXtProt entry for SCAMP3 Gene

Post-translational modifications for SCAMP3 Gene

  • Monoubiquitinated.
  • Ubiquitination at isoforms=2313, posLast=102102, posLast=101101, isoforms=281, and isoforms=274
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCAMP3 Gene

Domains & Families for SCAMP3 Gene

Gene Families for SCAMP3 Gene

Protein Domains for SCAMP3 Gene


Suggested Antigen Peptide Sequences for SCAMP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCAMP family.
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP3: view

Function for SCAMP3 Gene

Molecular function for SCAMP3 Gene

UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
GENATLAS Biochemistry:
secretory carrier membrane protein 3,widely expressed,as component of post-Golgi membranes,homolog of rat secretory carrier membrane protein 37 (SCAMP37),involved in cell surface recycling

Phenotypes From GWAS Catalog for SCAMP3 Gene

Gene Ontology (GO) - Molecular Function for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 23418353
genes like me logo Genes that share ontologies with SCAMP3: view
genes like me logo Genes that share phenotypes with SCAMP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP3 Gene

Localization for SCAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAMP3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
lysosome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with SCAMP3: view

Pathways & Interactions for SCAMP3 Gene

SuperPathways for SCAMP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SCAMP3: view

No data available for Pathways by source and SIGNOR curated interactions for SCAMP3 Gene

Drugs & Compounds for SCAMP3 Gene

No Compound Related Data Available

Transcripts for SCAMP3 Gene

mRNA/cDNA for SCAMP3 Gene

Unigene Clusters for SCAMP3 Gene

Secretory carrier membrane protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - -
SP16: -
SP17: - - - - - - - - -
SP18: - - - - - - - - - - -

ExUns: 9c ^ 10a · 10b · 10c · 10d

Relevant External Links for SCAMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAMP3 Gene

This gene is overexpressed in Nasal epithelium (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAMP3 Gene

Protein tissue co-expression partners for SCAMP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAMP3 Gene:


SOURCE GeneReport for Unigene cluster for SCAMP3 Gene:


mRNA Expression by UniProt/SwissProt for SCAMP3 Gene:

Tissue specificity: Widely expressed, with highest expression in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for SCAMP3 Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SCAMP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP3 Gene

Orthologs for SCAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCAMP3 34 33
  • 99.9 (n)
(Canis familiaris)
Mammalia SCAMP3 34 33
  • 92.89 (n)
(Bos Taurus)
Mammalia SCAMP3 34 33
  • 92.51 (n)
(Mus musculus)
Mammalia Scamp3 16 34 33
  • 88.18 (n)
(Rattus norvegicus)
Mammalia Scamp3 33
  • 87.51 (n)
(Monodelphis domestica)
Mammalia SCAMP3 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
(Gallus gallus)
Aves SCAMP3 34
  • 79 (a)
(Anolis carolinensis)
Reptilia SCAMP3 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp3 33
  • 71.16 (n)
Str.1919 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12686 33
(Danio rerio)
Actinopterygii scamp3 34 33
  • 64.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta Scamp 34 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea scm-1 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 34
  • 46 (a)
Species where no ortholog for SCAMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP3 Gene

Gene Tree for SCAMP3 (if available)
Gene Tree for SCAMP3 (if available)
Evolutionary constrained regions (ECRs) for SCAMP3: view image

Paralogs for SCAMP3 Gene

Paralogs for SCAMP3 Gene

(4) SIMAP similar genes for SCAMP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCAMP3: view

Variants for SCAMP3 Gene

Sequence variations from dbSNP and Humsavar for SCAMP3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000115651 -- 155,259,949(-) G/A/C intron_variant
rs1000529703 -- 155,260,123(-) TGTGTGTGTGT/TGTGTGT intron_variant
rs1001015417 -- 155,255,542(-) G/A downstream_transcript_variant
rs1001517739 -- 155,263,714(-) GAATCCAGGA/GA upstream_transcript_variant
rs1002216533 -- 155,262,872(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SCAMP3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv23319 CNV gain 19812545
esv2758971 CNV gain 17122850
esv33869 CNV loss 17666407
nsv1008748 CNV loss 25217958
nsv1011773 CNV gain 25217958
nsv436027 CNV insertion 17901297
nsv470741 CNV loss 18288195
nsv831636 CNV loss 17160897

Variation tolerance for SCAMP3 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP3 Gene

Disorders for SCAMP3 Gene

Additional Disease Information for SCAMP3

No disorders were found for SCAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP3 Gene

Publications for SCAMP3 Gene

  1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PMID: 9331372) Winfield SL … Sidransky E (Genome research 1997) 2 3 4 58
  2. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PMID: 23418353) Smith CJ … McGlade CJ (Journal of cell science 2013) 3 4 58
  3. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 44 58
  4. SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. (PMID: 19158374) Aoh QL … Castle JD (Molecular biology of the cell 2009) 3 4 58
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58

Products for SCAMP3 Gene

Sources for SCAMP3 Gene

Loading form....