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Aliases for SH2D3A Gene

Aliases for SH2D3A Gene

  • SH2 Domain Containing 3A 2 3 5
  • Novel SH2-Containing Protein 1 3 4
  • NSP1 3 4
  • SH2 Domain-Containing Protein 3A 3
  • SH2 Domain-Containing 3A 2

External Ids for SH2D3A Gene

Previous GeneCards Identifiers for SH2D3A Gene

  • GC19M006846
  • GC19M006692
  • GC19M006703
  • GC19M006514

Summaries for SH2D3A Gene

GeneCards Summary for SH2D3A Gene

SH2D3A (SH2 Domain Containing 3A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and SH3/SH2 adaptor activity. An important paralog of this gene is BCAR3.

UniProtKB/Swiss-Prot for SH2D3A Gene

  • May play a role in JNK activation.

Gene Wiki entry for SH2D3A Gene

Additional gene information for SH2D3A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH2D3A Gene

Genomics for SH2D3A Gene

GeneHancer (GH) Regulatory Elements for SH2D3A Gene

Promoters and enhancers for SH2D3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006765 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 705.5 +0.3 306 4.5 HDGF PKNOX1 ARID4B SIN3A ZNF207 ZNF143 FOS KLF13 SP3 SP5 SH2D3A C3 DUS3L XAB2 ZNF557 FLJ25758 MBD3L5 MBD3L3 LOC390877 RPL21P129
GH19J006771 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37 -5.4 -5418 2.3 PKNOX1 ATF1 ZNF143 RUNX3 ZNF623 NBN KDM1A CTCF KLF1 BACH1 VAV1 SH2D3A XAB2 DUS3L KHSRP ZNF557 ENSG00000267571 VMAC GPR108 DENND1C
GH19J006751 Enhancer 1.4 Ensembl ENCODE dbSUPER 31.8 +14.7 14711 3.3 HDGF PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 E2F8 ZNF207 ENSG00000269680 SH2D3A XAB2 DUS3L ZNF557 RANBP3 KHSRP ENSG00000267571 GTF2F1 PIR50354
GH19J006270 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +492.2 492236 10.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MLLT1 DUS3L ZNF557 KHSRP SNRPEP4 SAFB ENSG00000267571 VMAC ACSBG2 RANBP3
GH19J006360 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.8 +405.3 405318 2.8 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 E2F8 ZNF207 CLPP GC19P006361 GC19P006362 ENSG00000269802 ACER1 ENSG00000267571 DUS3L SNRPEP4 ZNF557 VMAC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SH2D3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SH2D3A gene promoter:
  • AML1a

Genomic Locations for SH2D3A Gene

Genomic Locations for SH2D3A Gene
chr19:6,752,160-6,767,588
(GRCh38/hg38)
Size:
15,429 bases
Orientation:
Minus strand
chr19:6,752,171-6,767,599
(GRCh37/hg19)
Size:
15,429 bases
Orientation:
Minus strand

Genomic View for SH2D3A Gene

Genes around SH2D3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SH2D3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SH2D3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH2D3A Gene

Proteins for SH2D3A Gene

  • Protein details for SH2D3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRG2-SH23A_HUMAN
    Recommended name:
    SH2 domain-containing protein 3A
    Protein Accession:
    Q9BRG2
    Secondary Accessions:
    • A8K9R6
    • B4DRS7
    • Q9Y2X4

    Protein attributes for SH2D3A Gene

    Size:
    576 amino acids
    Molecular mass:
    63093 Da
    Quaternary structure:
    • Interacts with BCAR1.

    Alternative splice isoforms for SH2D3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH2D3A Gene

Post-translational modifications for SH2D3A Gene

No data available for DME Specific Peptides for SH2D3A Gene

Domains & Families for SH2D3A Gene

Gene Families for SH2D3A Gene

Protein Domains for SH2D3A Gene

Suggested Antigen Peptide Sequences for SH2D3A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SH2D3A: view

No data available for UniProtKB/Swiss-Prot for SH2D3A Gene

Function for SH2D3A Gene

Molecular function for SH2D3A Gene

UniProtKB/Swiss-Prot Function:
May play a role in JNK activation.

Phenotypes From GWAS Catalog for SH2D3A Gene

Gene Ontology (GO) - Molecular Function for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 10187783
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 24658140
genes like me logo Genes that share ontologies with SH2D3A: view
genes like me logo Genes that share phenotypes with SH2D3A: view

Animal Model Products

CRISPR Products

miRNA for SH2D3A Gene

miRTarBase miRNAs that target SH2D3A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH2D3A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SH2D3A Gene

Localization for SH2D3A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SH2D3A gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SH2D3A Gene

Pathways & Interactions for SH2D3A Gene

SuperPathways for SH2D3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SH2D3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade TAS 10187783
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with SH2D3A: view

No data available for Pathways by source and SIGNOR curated interactions for SH2D3A Gene

Drugs & Compounds for SH2D3A Gene

(1) Drugs for SH2D3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SH2D3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SH2D3A: view

Transcripts for SH2D3A Gene

Unigene Clusters for SH2D3A Gene

SH2 domain containing 3A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SH2D3A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SH2D3A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:
SP6:

Relevant External Links for SH2D3A Gene

GeneLoc Exon Structure for
SH2D3A
ECgene alternative splicing isoforms for
SH2D3A

Expression for SH2D3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SH2D3A Gene

mRNA differential expression in normal tissues according to GTEx for SH2D3A Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for SH2D3A Gene

This gene is overexpressed in Stomach (29.7), Placenta (23.8), and Pancreas (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SH2D3A Gene



Protein tissue co-expression partners for SH2D3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SH2D3A Gene:

SH2D3A

SOURCE GeneReport for Unigene cluster for SH2D3A Gene:

Hs.439645

mRNA Expression by UniProt/SwissProt for SH2D3A Gene:

Q9BRG2-SH23A_HUMAN
Tissue specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.
genes like me logo Genes that share expression patterns with SH2D3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SH2D3A Gene

Orthologs for SH2D3A Gene

This gene was present in the common ancestor of animals.

Orthologs for SH2D3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH2D3A 34 33
  • 99.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SH2D3A 34 33
  • 84.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SH2D3A 34 33
  • 83.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SH2D3A 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01115881.1 34
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9098 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 34
  • 22 (a)
OneToMany
Species where no ortholog for SH2D3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SH2D3A Gene

ENSEMBL:
Gene Tree for SH2D3A (if available)
TreeFam:
Gene Tree for SH2D3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SH2D3A: view image

Paralogs for SH2D3A Gene

Paralogs for SH2D3A Gene

(3) SIMAP similar genes for SH2D3A Gene using alignment to 3 proteins:

  • SH23A_HUMAN
  • B4DRS7_HUMAN
  • M0QZQ6_HUMAN
genes like me logo Genes that share paralogs with SH2D3A: view

Variants for SH2D3A Gene

Sequence variations from dbSNP and Humsavar for SH2D3A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_035989 A breast cancer sample p.Glu265Gly
rs1000080921 -- 6,767,316(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000715635 -- 6,764,931(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000748471 -- 6,765,124(-) A/T genic_upstream_transcript_variant, intron_variant
rs1001037304 -- 6,753,700(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SH2D3A Gene

Variant ID Type Subtype PubMed ID
dgv14e196 CNV duplication 17116639
esv2661790 CNV deletion 23128226
esv3643564 CNV loss 21293372
nsv1055253 CNV gain 25217958
nsv470120 CNV loss 18288195
nsv519561 CNV loss 19592680
nsv519827 CNV loss 19592680

Variation tolerance for SH2D3A Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SH2D3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SH2D3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SH2D3A Gene

Disorders for SH2D3A Gene

Additional Disease Information for SH2D3A

No disorders were found for SH2D3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SH2D3A Gene

Publications for SH2D3A Gene

  1. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. (PMID: 10187783) Lu Y … Stewart TA (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near RI … Lerner A (Journal of cellular physiology 2007) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for SH2D3A Gene

Sources for SH2D3A Gene

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