Aliases for PARP2 Gene
- Poly(ADP-Ribose) Polymerase 2 2 3 5
- ADP-Ribosyltransferase (NAD+; Poly(ADP-Ribose) Polymerase)-Like 2 2 3
- ADP-Ribosyltransferase Diphtheria Toxin-Like 2 3 4
- Poly (ADP-Ribose) Polymerase Family, Member 2 2 3
- NAD(+) ADP-Ribosyltransferase 2 3 4
- Poly[ADP-Ribose] Synthase 2 3 4
- PADPRT-2 3 4
- ADPRTL2 3 4
- ADPRT-2 3 4
- HPARP-2 3 4
External Ids for PARP2 Gene
Previous HGNC Symbols for PARP2 Gene
Previous GeneCards Identifiers for PARP2 Gene
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
GeneCards Summary for PARP2 Gene
PARP2 (Poly(ADP-Ribose) Polymerase 2) is a Protein Coding gene. Diseases associated with PARP2 include Arts Syndrome. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP1.
UniProtKB/Swiss-Prot for PARP2 Gene
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768).
Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.