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Aliases for BCL2L10 Gene

Aliases for BCL2L10 Gene

  • BCL2 Like 10 2 3 5
  • BCL2-Like 10 (Apoptosis Facilitator) 2 3
  • Anti-Apoptotic Protein NrH 3 4
  • Apoptosis Regulator Bcl-B 3 4
  • Bcl2-L-10 3 4
  • Death Inducer Binding To VBcl-2 And Apaf-1 3
  • Bcl-2-Like Protein 10 3
  • BCL-B 3
  • Diva 3
  • BCLB 4
  • Boo 3

External Ids for BCL2L10 Gene

Previous GeneCards Identifiers for BCL2L10 Gene

  • GC15M047960
  • GC15M045448
  • GC15M049980
  • GC15M050117
  • GC15M050189
  • GC15M052401
  • GC15M029232
  • GC15M052415
  • GC15M052685
  • GC15M054207
  • GC15M054934
  • GC15M055375
  • GC15M055822
  • GC15M056259
  • GC15M056708

Summaries for BCL2L10 Gene

Entrez Gene Summary for BCL2L10 Gene

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL2L10 Gene

BCL2L10 (BCL2 Like 10) is a Protein Coding gene. Diseases associated with BCL2L10 include Prostatic Cyst and Urethral Stricture. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for BCL2L10 Gene

  • Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

Gene Wiki entry for BCL2L10 Gene

Additional gene information for BCL2L10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L10 Gene

Genomics for BCL2L10 Gene

GeneHancer (GH) Regulatory Elements for BCL2L10 Gene

Promoters and enhancers for BCL2L10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J052133 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 663.2 -21.7 -21738 2.9 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 BCL2L10 GNB5 MAPK6 CERNA1 ENSG00000259709 GC15P052163 GC15P052002
GH15J052112 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +0.6 622 0.8 ZNF687 MAX TRIM22 DPF2 ZNF592 YY1 POLR2A IKZF1 MLLT1 ZBTB33 BCL2L10 GNB5 ENSG00000259712 GC15P052002
GH15J052018 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.5 +92.2 92174 5.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 MAPK6 MAPK6-DT ENSG00000259935 ENSG00000259712 ENSG00000260618 FAM214A BCL2L10 LYSMD2 DMXL2 ENSG00000259398
GH15J052076 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +34.5 34546 4.7 PKNOX1 FOXA2 ARID4B DMAP1 IRF4 ZNF48 YY1 TCF12 ZNF143 ZFP91 MAPK6 BCL2L10 LYSMD2 GNB5 ENSG00000259178 DMXL2 ENSG00000259712 ENSG00000259398 GC15P052002
GH15J052071 Enhancer 1.1 ENCODE dbSUPER 12.7 +41.2 41214 1.4 ELF3 PKNOX1 FOXA2 CLOCK MLX ARID4B NEUROD1 SIN3A RAD21 RFX5 BCL2L10 MAPK6 GNB5 CERNA1 ENSG00000259178 ENSG00000259712 ENSG00000259398 GC15P052002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL2L10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL2L10 gene promoter:
  • GATA-3
  • C/EBPalpha
  • ZID
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • Lmo2

Genomic Locations for BCL2L10 Gene

Genomic Locations for BCL2L10 Gene
3,780 bases
Minus strand
3,513 bases
Minus strand

Genomic View for BCL2L10 Gene

Genes around BCL2L10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L10 Gene

Proteins for BCL2L10 Gene

  • Protein details for BCL2L10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 10
    Protein Accession:
    Secondary Accessions:
    • Q3SX80
    • Q52LQ9
    • Q8TCS9

    Protein attributes for BCL2L10 Gene

    194 amino acids
    Molecular mass:
    21973 Da
    Quaternary structure:
    • Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.
    • Sequence=AAG00503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93826.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04443.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04444.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK48715.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L10 Gene

neXtProt entry for BCL2L10 Gene

Post-translational modifications for BCL2L10 Gene

  • Ubiquitination at posLast=110110 and Lys109
  • Modification sites at PhosphoSitePlus

Other Protein References for BCL2L10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2L10 Gene

Domains & Families for BCL2L10 Gene

Gene Families for BCL2L10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for BCL2L10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L10: view

Function for BCL2L10 Gene

Molecular function for BCL2L10 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

Gene Ontology (GO) - Molecular Function for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278245
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
GO:0089720 caspase binding IPI 19255499
genes like me logo Genes that share ontologies with BCL2L10: view
genes like me logo Genes that share phenotypes with BCL2L10: view

Animal Models for BCL2L10 Gene

MGI Knock Outs for BCL2L10:

Animal Model Products

miRNA for BCL2L10 Gene

miRTarBase miRNAs that target BCL2L10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L10 Gene

Localization for BCL2L10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L10 Gene

Mitochondrion. Nucleus membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L10 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 4
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA 11278245
GO:0005741 mitochondrial outer membrane IBA --
GO:0005829 cytosol IDA 11278245
GO:0016020 membrane TAS 9878060
genes like me logo Genes that share ontologies with BCL2L10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCL2L10 Gene

Pathways & Interactions for BCL2L10 Gene

genes like me logo Genes that share pathways with BCL2L10: view

Pathways by source for BCL2L10 Gene

1 GeneGo (Thomson Reuters) pathway for BCL2L10 Gene
1 Cell Signaling Technology pathway for BCL2L10 Gene

Gene Ontology (GO) - Biological Process for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS 9829980
GO:0007283 spermatogenesis TAS 9878060
GO:0007292 female gamete generation TAS 9878060
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
genes like me logo Genes that share ontologies with BCL2L10: view

No data available for SIGNOR curated interactions for BCL2L10 Gene

Drugs & Compounds for BCL2L10 Gene

No Compound Related Data Available

Transcripts for BCL2L10 Gene

mRNA/cDNA for BCL2L10 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCL2L10 Gene

BCL2-like 10 (apoptosis facilitator):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L10 Gene

No ASD Table

Relevant External Links for BCL2L10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L10 Gene

This gene is overexpressed in Liver (x6.4).

Protein differential expression in normal tissues from HIPED for BCL2L10 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL2L10 Gene

Protein tissue co-expression partners for BCL2L10 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL2L10 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L10 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L10 Gene:

Tissue specificity: Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.

Evidence on tissue expression from TISSUES for BCL2L10 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with BCL2L10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L10 Gene

Orthologs for BCL2L10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BCL2L10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L10 34 33
  • 98.2 (n)
(Bos Taurus)
Mammalia BCL2L10 33
  • 69.75 (n)
-- 34
  • 55 (a)
-- 34
  • 48 (a)
(Mus musculus)
Mammalia Bcl2l10 16 34 33
  • 67.03 (n)
(Rattus norvegicus)
Mammalia Bcl2l10 33
  • 65.93 (n)
Species where no ortholog for BCL2L10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L10 Gene

Gene Tree for BCL2L10 (if available)
Gene Tree for BCL2L10 (if available)
Evolutionary constrained regions (ECRs) for BCL2L10: view image

Paralogs for BCL2L10 Gene

No data available for Paralogs for BCL2L10 Gene

Variants for BCL2L10 Gene

Sequence variations from dbSNP and Humsavar for BCL2L10 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000100146 -- 52,111,654(-) G/T intron_variant
rs1001396332 -- 52,111,185(-) C/A intron_variant
rs1001516840 -- 52,110,483(-) G/C intron_variant
rs1002493101 -- 52,109,705(-) C/T 3_prime_UTR_variant
rs1002525963 -- 52,111,679(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L10 Gene

Variant ID Type Subtype PubMed ID
nsv471244 CNV gain 18288195
nsv833005 CNV gain 17160897
nsv952627 CNV deletion 24416366

Variation tolerance for BCL2L10 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL2L10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L10 Gene

Disorders for BCL2L10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BCL2L10 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
prostatic cyst
  • cyst of prostate
urethral stricture
avian influenza
  • avian flu
phlebotomus fever
  • pappataci fever
urethral syndrome
  • urethral disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BCL2L10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BCL2L10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L10 Gene

Publications for BCL2L10 Gene

  1. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. (PMID: 11278245) Ke N … Reed JC (The Journal of biological chemistry 2001) 3 4 22 58
  2. Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. (PMID: 11689480) Zhang H … De Geyter C (Human molecular genetics 2001) 3 4 22 58
  3. Boo, a novel negative regulator of cell death, interacts with Apaf-1. (PMID: 9878060) Song Q … Vincenz C (The EMBO journal 1999) 2 3 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for BCL2L10 Gene

Sources for BCL2L10 Gene

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