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Aliases for PPP1R1B Gene

Aliases for PPP1R1B Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B 2 3 5
  • DARPP-32 3 4
  • DARPP32 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B 2
  • Dopamine And CAMP-Regulated Neuronal Phosphoprotein 32 3
  • Dopamine- And CAMP-Regulated Neuronal Phosphoprotein 4
  • Protein Phosphatase 1 Regulatory Subunit 1B 3
  • Dopamine And CAMP Regulated Phosphoprotein 2

External Ids for PPP1R1B Gene

Previous GeneCards Identifiers for PPP1R1B Gene

  • GC17P037283
  • GC17P039780
  • GC17P037693
  • GC17P038158
  • GC17P035036
  • GC17P037783
  • GC17P033576

Summaries for PPP1R1B Gene

Entrez Gene Summary for PPP1R1B Gene

  • This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R1B Gene

PPP1R1B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B) is a Protein Coding gene. Diseases associated with PPP1R1B include Schizophrenia and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Beta-Adrenergic Signaling and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R1B Gene

  • Inhibitor of protein-phosphatase 1.

Gene Wiki entry for PPP1R1B Gene

Additional gene information for PPP1R1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R1B Gene

Genomics for PPP1R1B Gene

GeneHancer (GH) Regulatory Elements for PPP1R1B Gene

Promoters and enhancers for PPP1R1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I039626 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 561.9 +1.9 1900 3.7 HDAC1 MEIS2 KLF1 PKNOX1 SAP130 BACH1 ZIC2 ZNF48 HIC1 ZNF335 PPP1R1B STARD3 PGAP3 RAPGEFL1 PNMT
GH17I039635 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +11.0 11012 3.2 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 STARD3 MED24 CDK12 SNORA21 MED1 LOC105371762 PPP1R1B PGAP3 MSL1 SNORD124
GH17I038876 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.7 -744.1 -744059 11.1 SMAD1 ARNT ZFP64 ARID4B FEZF1 GLI4 YY1 ETS1 GLIS2 RUNX3 SNORA21 MED1 RPS20P35 RPL23 SNORA21B C17orf98 CWC25 PSMB3 LASP1 PCGF2
GH17I040061 Promoter/Enhancer 2.9 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.5 +443.1 443087 14.8 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 THRA GC17P040067 MED1 MED24 SMARCE1 MSL1 GSDMA CDK12 RAPGEFL1 PSMD3
GH17I039621 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.8 -4.1 -4125 1.1 MLX ARID4B SIN3A ZNF2 IRF4 ZNF48 SLC30A9 GLIS2 ARID2 ZNF143 CDK12 STARD3 LOC105371762 SNORA21 MED1 MSL1 RPL23 RPL19 ENSG00000214546 PPP1R1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R1B gene promoter:

Genomic Locations for PPP1R1B Gene

Genomic Locations for PPP1R1B Gene
10,419 bases
Plus strand

Genomic View for PPP1R1B Gene

Genes around PPP1R1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R1B Gene

Proteins for PPP1R1B Gene

  • Protein details for PPP1R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1B
    Protein Accession:
    Secondary Accessions:
    • Q547V9
    • Q547W0
    • Q9H7G1

    Protein attributes for PPP1R1B Gene

    204 amino acids
    Molecular mass:
    22963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPP1R1B Gene


neXtProt entry for PPP1R1B Gene

Post-translational modifications for PPP1R1B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPP1R1B (DARPP-32)
  • Abcam antibodies for PPP1R1B

No data available for DME Specific Peptides for PPP1R1B Gene

Domains & Families for PPP1R1B Gene

Gene Families for PPP1R1B Gene

Protein Domains for PPP1R1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein phosphatase inhibitor 1 family.
  • Belongs to the protein phosphatase inhibitor 1 family.
genes like me logo Genes that share domains with PPP1R1B: view

Function for PPP1R1B Gene

Molecular function for PPP1R1B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.

Phenotypes From GWAS Catalog for PPP1R1B Gene

Gene Ontology (GO) - Molecular Function for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 10604473
GO:0004862 cAMP-dependent protein kinase inhibitor activity TAS --
GO:0004864 protein phosphatase inhibitor activity TAS,IDA 10604473
GO:0004865 protein serine/threonine phosphatase inhibitor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PPP1R1B: view
genes like me logo Genes that share phenotypes with PPP1R1B: view

Animal Models for PPP1R1B Gene

MGI Knock Outs for PPP1R1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R1B Gene

Localization for PPP1R1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R1B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R1B gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R1B Gene

Pathways & Interactions for PPP1R1B Gene

genes like me logo Genes that share pathways with PPP1R1B: view

Gene Ontology (GO) - Biological Process for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007165 signal transduction TAS 10604473
GO:0007621 negative regulation of female receptivity IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view

No data available for SIGNOR curated interactions for PPP1R1B Gene

Drugs & Compounds for PPP1R1B Gene

(14) Drugs for PPP1R1B Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ITI-007 Pharma 0

(2) Additional Compounds for PPP1R1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPP1R1B: view

Transcripts for PPP1R1B Gene

Unigene Clusters for PPP1R1B Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP5: - - -
SP6: - -

Relevant External Links for PPP1R1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R1B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R1B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x13.4), Brain - Caudate (basal ganglia) (x11.5), and Brain - Nucleus accumbens (basal ganglia) (x9.5).

Protein differential expression in normal tissues from HIPED for PPP1R1B Gene

This gene is overexpressed in Skin (24.0), Brain (15.5), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPP1R1B Gene

Protein tissue co-expression partners for PPP1R1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R1B Gene:


SOURCE GeneReport for Unigene cluster for PPP1R1B Gene:


Evidence on tissue expression from TISSUES for PPP1R1B Gene

  • Nervous system(4.9)
  • Intestine(4.7)
genes like me logo Genes that share expression patterns with PPP1R1B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R1B Gene

Orthologs for PPP1R1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R1B 33 34
  • 98.03 (n)
(Bos Taurus)
Mammalia PPP1R1B 33 34
  • 90.26 (n)
(Canis familiaris)
Mammalia PPP1R1B 33 34
  • 89.38 (n)
(Mus musculus)
Mammalia Ppp1r1b 33 16 34
  • 86.63 (n)
(Rattus norvegicus)
Mammalia Ppp1r1b 33
  • 86.6 (n)
(Monodelphis domestica)
Mammalia PPP1R1B 34
  • 74 (a)
(Gallus gallus)
Aves PPP1R1B 34
  • 48 (a)
(Danio rerio)
Actinopterygii ppp1r1b 34
  • 34 (a)
Species where no ortholog for PPP1R1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R1B Gene

Gene Tree for PPP1R1B (if available)
Gene Tree for PPP1R1B (if available)

Paralogs for PPP1R1B Gene

(3) SIMAP similar genes for PPP1R1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PPP1R1B: view

No data available for Paralogs for PPP1R1B Gene

Variants for PPP1R1B Gene

Sequence variations from dbSNP and Humsavar for PPP1R1B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs367543178 not-provided, not provided 39,627,464(+) G/A coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant, upstream_transcript_variant
rs367543179 not-provided, not provided 39,629,174(+) G/A/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs367543180 not-provided, not provided 39,634,034(+) G/A coding_sequence_variant, synonymous_variant
rs367543181 not-provided, not provided 39,635,654(+) C/A/T coding_sequence_variant, missense_variant
rs1000015269 -- 39,628,453(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R1B Gene

Variant ID Type Subtype PubMed ID
nsv574991 CNV loss 21841781
nsv521294 CNV loss 19592680
nsv516757 CNV loss 19592680
nsv457738 CNV loss 19166990
nsv2047 CNV insertion 18451855
nsv1146669 OTHER inversion 26484159
dgv40n68 CNV loss 17160897

Variation tolerance for PPP1R1B Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R1B Gene

Disorders for PPP1R1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPP1R1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • sczd
attention deficit-hyperactivity disorder
  • adhd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R1B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPP1R1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R1B Gene

Publications for PPP1R1B Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brené S … Persson H (The Journal of neuroscience : the official journal of the Society for Neuroscience 1994) 2 3 4 22 58
  2. The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. (PMID: 19463699) Reuter M … Montag C (Behavioural brain research 2009) 3 22 44 58
  3. Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PMID: 17171661) Beuten J … Li MD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 44 58
  4. An association study between PPP1R1B gene and schizophrenia in the Chinese population. (PMID: 17618027) Hu JX … He L (Progress in neuro-psychopharmacology & biological psychiatry 2007) 3 22 44 58
  5. Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PMID: 16750903) Li CH … Chen CH (Schizophrenia research 2006) 3 22 44 58

Products for PPP1R1B Gene

Sources for PPP1R1B Gene

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