Aliases for ELOVL2 Gene
- ELOVL Fatty Acid Elongase 2 2 3 4 5
- Elongation Of Very Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3, Yeast)-Like 2 2 3
- Very Long Chain 3-Ketoacyl-CoA Synthase 2 3 4
- Very Long Chain 3-Oxoacyl-CoA Synthase 2 3 4
- 3-Keto Acyl-CoA Synthase ELOVL2 3 4
- ELOVL FA Elongase 2 3 4
- SSC2 3 4
- Elongation Of Very Long Chain Fatty Acids Protein 2 3
- EC 184.108.40.206 4
External Ids for ELOVL2 Gene
Previous GeneCards Identifiers for ELOVL2 Gene
GeneCards Summary for ELOVL2 Gene
ELOVL2 (ELOVL Fatty Acid Elongase 2) is a Protein Coding gene. Diseases associated with ELOVL2 include Melanoma, Cutaneous Malignant 1. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and fatty acid elongase activity. An important paralog of this gene is ELOVL5.
UniProtKB/Swiss-Prot for ELOVL2 Gene
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.