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Aliases for ZNF665 Gene

Aliases for ZNF665 Gene

  • Zinc Finger Protein 665 2 3 3 5
  • ZFP160L 3 4
  • Zinc Finger Protein 160-Like 4

External Ids for ZNF665 Gene

Previous GeneCards Identifiers for ZNF665 Gene

  • GC19M058358
  • GC19M053667
  • GC19M049990

Summaries for ZNF665 Gene

GeneCards Summary for ZNF665 Gene

ZNF665 (Zinc Finger Protein 665) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF184.

UniProtKB/Swiss-Prot for ZNF665 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF665 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF665 Gene

Genomics for ZNF665 Gene

GeneHancer (GH) Regulatory Elements for ZNF665 Gene

Promoters and enhancers for ZNF665 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053192 Promoter/Enhancer 1.3 Ensembl ENCODE 664.2 +0.3 308 1.9 HDAC1 MXI1 TAF9B SIN3A ZBTB40 E4F1 E2F1 GATA3 POLR2A VEZF1 ZNF665 ZNF347
GH19J054186 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 32.4 -996.2 -996226 6.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 TSEN34 MBOAT7 PRPF31 ZNF665 ZNF677 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525
GH19J053977 Promoter/Enhancer 1.7 Ensembl ENCODE 39.9 -786.6 -786566 5.8 HDGF PKNOX1 CLOCK SIN3A FEZF1 ZNF2 ZNF766 ZNF213 ZNF143 SP3 PRPF31 ZNF525 LENG8-AS1 ZNF160 ZNF845 ZNF665 ZNF761 ZNF347 LENG8 ENSG00000235681
GH19J053864 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.8 -675.5 -675518 9.8 HDGF FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 MYADM LOC105372457 ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6
GH19J052961 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.8 +230.7 230738 2.5 HDGF ATF1 ARID4B SIN3A DMAP1 YY1 ETS1 POLR2B GLIS2 E2F8 ZNF816 ENSG00000283088 ZNF816-ZNF321P ZNF137P ZNF665 ENSG00000268970 ZNF701 ZNF611 ENSG00000269001 TPM3P9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF665 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF665 gene promoter:
  • ATF6
  • Ik-1

Genomic Locations for ZNF665 Gene

Genomic Locations for ZNF665 Gene
34,184 bases
Minus strand
34,174 bases
Minus strand

Genomic View for ZNF665 Gene

Genes around ZNF665 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF665 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF665 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF665 Gene

Proteins for ZNF665 Gene

  • Protein details for ZNF665 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 665
    Protein Accession:
    Secondary Accessions:
    • A8K5T8

    Protein attributes for ZNF665 Gene

    613 amino acids
    Molecular mass:
    70223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF665 Gene


neXtProt entry for ZNF665 Gene

Post-translational modifications for ZNF665 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF665 Gene

No data available for DME Specific Peptides for ZNF665 Gene

Domains & Families for ZNF665 Gene

Gene Families for ZNF665 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF665 Gene

Suggested Antigen Peptide Sequences for ZNF665 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF665: view

Function for ZNF665 Gene

Molecular function for ZNF665 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF665 Gene

Gene Ontology (GO) - Molecular Function for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF665: view
genes like me logo Genes that share phenotypes with ZNF665: view

Animal Model Products

CRISPR Products

miRNA for ZNF665 Gene

miRTarBase miRNAs that target ZNF665

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF665

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF665 Gene

Localization for ZNF665 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF665 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF665 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF665: view

Pathways & Interactions for ZNF665 Gene

SuperPathways for ZNF665 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF665: view

Pathways by source for ZNF665 Gene

2 Reactome pathways for ZNF665 Gene

Interacting Proteins for ZNF665 Gene

Gene Ontology (GO) - Biological Process for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF665: view

No data available for SIGNOR curated interactions for ZNF665 Gene

Drugs & Compounds for ZNF665 Gene

No Compound Related Data Available

Transcripts for ZNF665 Gene

mRNA/cDNA for ZNF665 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF665 Gene

Zinc finger protein 665:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF665

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF665 Gene

No ASD Table

Relevant External Links for ZNF665 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF665 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF665 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF665 Gene

Protein tissue co-expression partners for ZNF665 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF665 Gene:


SOURCE GeneReport for Unigene cluster for ZNF665 Gene:


Evidence on tissue expression from TISSUES for ZNF665 Gene

  • Thyroid gland(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF665: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF665 Gene

Orthologs for ZNF665 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF665 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF665 34 33
  • 98.92 (n)
(Rattus norvegicus)
Mammalia LOC100365363 33
  • 72.65 (n)
(Mus musculus)
Mammalia Zfp160 16 34 33
  • 71.47 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 40 (a)
(Bos Taurus)
Mammalia -- 34
  • 50 (a)
Species where no ortholog for ZNF665 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF665 Gene

Gene Tree for ZNF665 (if available)
Gene Tree for ZNF665 (if available)
Evolutionary constrained regions (ECRs) for ZNF665: view image

Paralogs for ZNF665 Gene

(538) SIMAP similar genes for ZNF665 Gene using alignment to 1 proteins:

  • ZN665_HUMAN Pseudogenes for ZNF665 Gene

genes like me logo Genes that share paralogs with ZNF665: view

Variants for ZNF665 Gene

Sequence variations from dbSNP and Humsavar for ZNF665 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000268467 -- 53,191,708(-) G/A intron_variant
rs1000301168 -- 53,191,462(-) T/C intron_variant
rs1000315901 -- 53,179,561(-) C/T intron_variant
rs1000355836 -- 53,192,965(-) G/A intron_variant
rs1000477979 -- 53,171,184(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF665 Gene

Variant ID Type Subtype PubMed ID
dgv1812n106 CNV deletion 24896259
dgv3644n100 CNV gain 25217958
dgv430n27 CNV gain 19166990
esv1006343 CNV deletion 20482838
esv1301232 CNV deletion 17803354
esv2611703 CNV deletion 19546169
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv2718813 CNV deletion 23290073
esv2762999 CNV gain 21179565
esv3556584 CNV deletion 23714750
esv3574753 CNV gain 25503493
esv3644740 CNV gain 21293372
esv3644741 CNV gain 21293372
esv3644742 CNV gain 21293372
esv3644743 CNV loss 21293372
esv3893240 CNV loss 25118596
nsv1071945 CNV deletion 25765185
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv1146588 CNV deletion 26484159
nsv435701 CNV deletion 17901297
nsv512592 CNV loss 21212237
nsv580077 CNV loss 21841781
nsv580078 CNV gain 21841781
nsv956581 CNV deletion 24416366
nsv960867 CNV duplication 23825009

Variation tolerance for ZNF665 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF665 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF665 Gene

Disorders for ZNF665 Gene

Additional Disease Information for ZNF665

No disorders were found for ZNF665 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF665 Gene

Publications for ZNF665 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genome-wide association study to identify genetic determinants of severe asthma. (PMID: 22561531) Wan YI … Hall IP (Thorax 2012) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF665 Gene

Sources for ZNF665 Gene

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