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Aliases for ZNF75A Gene

Aliases for ZNF75A Gene

  • Zinc Finger Protein 75a 2 3 5
  • Zinc Finger Protein 75A 3

External Ids for ZNF75A Gene

Previous GeneCards Identifiers for ZNF75A Gene

  • GC16U990066
  • GC16P003389
  • GC16P003355
  • GC16P003295
  • GC16P003325
  • GC16P003306
  • GC16P003318
  • GC16P003375
  • GC16P003410
  • GC16P003455
  • GC16P003488

Summaries for ZNF75A Gene

GeneCards Summary for ZNF75A Gene

ZNF75A (Zinc Finger Protein 75a) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF75D.

UniProtKB/Swiss-Prot for ZNF75A Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF75A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF75A Gene

Genomics for ZNF75A Gene

GeneHancer (GH) Regulatory Elements for ZNF75A Gene

Promoters and enhancers for ZNF75A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003304 Promoter/Enhancer 1.5 Ensembl ENCODE 678.4 -0.1 -100 2.2 HDGF PKNOX1 SMAD1 SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 E2F8 ZNF75A GC16P003602 TIGD7 ZNF263 CREBBP ENSG00000261938 ZNF597 AMDHD2 SRRM2 LOC105371055
GH16J004270 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 54 +967.3 967309 4.5 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TFAP4 GC16P004274 ZNF75A ZNF500 CREBBP ANKS3 ENSG00000261938 TIGD7 ENSG00000261789 LOC105371067
GH16J003156 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 65 -146.6 -146612 3.8 DMAP1 YY1 ZNF213 E2F8 SP3 MEF2D SSRP1 ZNF610 GLIS1 NBN GC16M003157 TRK-CTT3-1 TRP-TGG3-3 ZNF75A E4F1 ZNF213-AS1 ZNF205 ENSG00000261938 CREBBP ZNF263
GH16J003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 58.6 -283.1 -283103 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 SRRM2 E4F1 CREBBP TSC2 ERVK13-1
GH16J002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 50.2 -552.3 -552334 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 GC16P003532 SRRM2-AS1 ZNF75A ZNF263 TSC2 ERVK13-1 ZNF213-AS1 E4F1 ENSG00000261938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF75A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF75A gene promoter:
  • MZF-1
  • Ik-2
  • Meis-1b
  • Meis-1a
  • Meis-1
  • GATA-1
  • FOXL1

Genomic Locations for ZNF75A Gene

Genomic Locations for ZNF75A Gene
chr16:3,305,406-3,318,852
(GRCh38/hg38)
Size:
13,447 bases
Orientation:
Plus strand
chr16:3,355,406-3,368,852
(GRCh37/hg19)
Size:
13,447 bases
Orientation:
Plus strand

Genomic View for ZNF75A Gene

Genes around ZNF75A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF75A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF75A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF75A Gene

Proteins for ZNF75A Gene

  • Protein details for ZNF75A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N20-ZN75A_HUMAN
    Recommended name:
    Zinc finger protein 75A
    Protein Accession:
    Q96N20
    Secondary Accessions:
    • Q0VDI8
    • Q92669

    Protein attributes for ZNF75A Gene

    Size:
    296 amino acids
    Molecular mass:
    34694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF75A Gene

Post-translational modifications for ZNF75A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF75A Gene

Domains & Families for ZNF75A Gene

Gene Families for ZNF75A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF75A Gene

Suggested Antigen Peptide Sequences for ZNF75A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N20

UniProtKB/Swiss-Prot:

ZN75A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF75A: view

Function for ZNF75A Gene

Molecular function for ZNF75A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 75,related sequence A

Phenotypes From GWAS Catalog for ZNF75A Gene

Gene Ontology (GO) - Molecular Function for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ZNF75A: view
genes like me logo Genes that share phenotypes with ZNF75A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF75A Gene

Localization for ZNF75A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF75A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF75A gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF75A: view

Pathways & Interactions for ZNF75A Gene

SuperPathways for ZNF75A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF75A: view

Pathways by source for ZNF75A Gene

2 Reactome pathways for ZNF75A Gene

Interacting Proteins for ZNF75A Gene

Gene Ontology (GO) - Biological Process for ZNF75A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF75A: view

No data available for SIGNOR curated interactions for ZNF75A Gene

Drugs & Compounds for ZNF75A Gene

No Compound Related Data Available

Transcripts for ZNF75A Gene

Unigene Clusters for ZNF75A Gene

Zinc finger protein 75a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF75A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for ZNF75A Gene

GeneLoc Exon Structure for
ZNF75A
ECgene alternative splicing isoforms for
ZNF75A

Expression for ZNF75A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF75A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF75A Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF75A Gene:

ZNF75A

SOURCE GeneReport for Unigene cluster for ZNF75A Gene:

Hs.513292

Evidence on tissue expression from TISSUES for ZNF75A Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZNF75A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF75A Gene

Orthologs for ZNF75A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF75A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF75A 34 33
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF75A 33
  • 89.94 (n)
-- 34
  • 50 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF75A 34 33
  • 88.36 (n)
OneToMany
-- 34
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF75A 34
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 4 (a)
OneToMany
Species where no ortholog for ZNF75A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF75A Gene

ENSEMBL:
Gene Tree for ZNF75A (if available)
TreeFam:
Gene Tree for ZNF75A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF75A: view image

Paralogs for ZNF75A Gene

Paralogs for ZNF75A Gene

(445) SIMAP similar genes for ZNF75A Gene using alignment to 2 proteins:

  • ZN75A_HUMAN
  • I3L2I5_HUMAN
genes like me logo Genes that share paralogs with ZNF75A: view

Variants for ZNF75A Gene

Sequence variations from dbSNP and Humsavar for ZNF75A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
VAR_035570 A breast cancer sample p.Gln228Glu
rs1000239965 -- 3,317,432(+) A/G 3_prime_UTR_variant, coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000286048 -- 3,308,477(+) A/G coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000289238 -- 3,303,924(+) C/G upstream_transcript_variant
rs1000295054 -- 3,312,568(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF75A Gene

Variant ID Type Subtype PubMed ID
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958

Variation tolerance for ZNF75A Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF75A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF75A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF75A Gene

Disorders for ZNF75A Gene

Additional Disease Information for ZNF75A

No disorders were found for ZNF75A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF75A Gene

Publications for ZNF75A Gene

  1. The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. (PMID: 8661144) Villa A … Vezzoni P (Genomics 1996) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for ZNF75A Gene

Sources for ZNF75A Gene

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