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Aliases for COL26A1 Gene

Aliases for COL26A1 Gene

  • Collagen Type XXVI Alpha 1 Chain 2 3 5
  • Emilin And Multimerin Domain-Containing Protein 2 3 4
  • Collagen, Type XXVI, Alpha 1 2 3
  • EMI Domain Containing 2 2 3
  • EMID2 3 4
  • EMU2 3 4
  • EMI Domain-Containing Protein 2 4
  • Collagen Alpha-1(XXVI) Chain 3
  • Alpha-1 Type XXVI Collagen 4
  • Emu2 Gene 2
  • EMI6 3
  • SH2B 3
  • Emu2 4

External Ids for COL26A1 Gene

Previous HGNC Symbols for COL26A1 Gene

  • EMID2

Previous GeneCards Identifiers for COL26A1 Gene

  • GC07P099489
  • GC07P100552
  • GC07P100566
  • GC07P101007

Summaries for COL26A1 Gene

Entrez Gene Summary for COL26A1 Gene

  • This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for COL26A1 Gene

COL26A1 (Collagen Type XXVI Alpha 1 Chain) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Degradation of the extracellular matrix. An important paralog of this gene is EMID1.

Gene Wiki entry for COL26A1 Gene

Additional gene information for COL26A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL26A1 Gene

Genomics for COL26A1 Gene

GeneHancer (GH) Regulatory Elements for COL26A1 Gene

Promoters and enhancers for COL26A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J101362 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 685.6 +0.8 820 2.1 CLOCK SIN3A ZNF2 ZNF48 GLIS2 ZNF143 KLF7 RUNX3 REST ZNF610 COL26A1 NYAP1 FIS1 ENSG00000233683
GH07J101307 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 31.7 -54.3 -54267 1.7 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B KLF7 SP3 LOC101927746 COL26A1 NAT16 VGF PIR32353
GH07J101400 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +39.3 39293 2.4 HDAC1 NFIB YBX1 FEZF1 NFXL1 ZEB1 ETS1 ZNF335 GLIS2 ZNF366 COL26A1 GIGYF1 PCOLCE ENSG00000239486 SRRT PPP1R35 LOC101927746 GC07M101393 GC07M101408
GH07J101410 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.1 +48.8 48786 1.6 ZSCAN4 ARID4B KLF17 SIN3A BMI1 ZNF2 ZBTB7B RAD21 ZNF335 ZNF121 GC07M101408 COL26A1 ACHE GC07M101501
GH07J101385 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.4 +23.9 23914 1.5 FOXA2 ARID4B DMAP1 ZNF48 ZNF121 GLIS2 RXRA MXD4 MIER2 REST COL26A1 FIS1 LOC101927746 ENSG00000233683
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COL26A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for COL26A1 Gene

Genomic Locations for COL26A1 Gene
chr7:101,362,820-101,559,024
(GRCh38/hg38)
Size:
196,205 bases
Orientation:
Plus strand
chr7:101,006,101-101,202,304
(GRCh37/hg19)
Size:
196,204 bases
Orientation:
Plus strand

Genomic View for COL26A1 Gene

Genes around COL26A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COL26A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COL26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL26A1 Gene

Proteins for COL26A1 Gene

  • Protein details for COL26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A83-COQA1_HUMAN
    Recommended name:
    Collagen alpha-1(XXVI) chain
    Protein Accession:
    Q96A83
    Secondary Accessions:
    • Q32M90

    Protein attributes for COL26A1 Gene

    Size:
    441 amino acids
    Molecular mass:
    45381 Da
    Quaternary structure:
    • Homotrimer or heterotrimer.

    Three dimensional structures from OCA and Proteopedia for COL26A1 Gene

    Alternative splice isoforms for COL26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COL26A1 Gene

Post-translational modifications for COL26A1 Gene

  • Hydroxylated on proline residues.
  • Glycosylation at posLast=358358, posLast=343343, Thr339, posLast=132132, and Asn70
  • Modification sites at PhosphoSitePlus

Other Protein References for COL26A1 Gene

No data available for DME Specific Peptides for COL26A1 Gene

Domains & Families for COL26A1 Gene

Gene Families for COL26A1 Gene

Protein Domains for COL26A1 Gene

Suggested Antigen Peptide Sequences for COL26A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COL26A1: view

No data available for UniProtKB/Swiss-Prot for COL26A1 Gene

Function for COL26A1 Gene

Phenotypes From GWAS Catalog for COL26A1 Gene

genes like me logo Genes that share phenotypes with COL26A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COL26A1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COL26A1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COL26A1 Gene

Localization for COL26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL26A1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for Subcellular locations from COMPARTMENTS for COL26A1 Gene

Pathways & Interactions for COL26A1 Gene

genes like me logo Genes that share pathways with COL26A1: view

Interacting Proteins for COL26A1 Gene

Gene Ontology (GO) - Biological Process for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for SIGNOR curated interactions for COL26A1 Gene

Drugs & Compounds for COL26A1 Gene

(2) Drugs for COL26A1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1232
Citalopram Approved Pharma 526
genes like me logo Genes that share compounds with COL26A1: view

Transcripts for COL26A1 Gene

mRNA/cDNA for COL26A1 Gene

Unigene Clusters for COL26A1 Gene

Collagen, type XXVI, alpha 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COL26A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COL26A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for COL26A1 Gene

GeneLoc Exon Structure for
COL26A1
ECgene alternative splicing isoforms for
COL26A1

Expression for COL26A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COL26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COL26A1 Gene

This gene is overexpressed in Brain - Cortex (x11.0), Brain - Frontal Cortex (BA9) (x8.3), and Brain - Anterior cingulate cortex (BA24) (x6.3).

Protein differential expression in normal tissues from HIPED for COL26A1 Gene

This gene is overexpressed in Placenta (53.4) and Testis (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COL26A1 Gene



Protein tissue co-expression partners for COL26A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of COL26A1 Gene:

COL26A1

SOURCE GeneReport for Unigene cluster for COL26A1 Gene:

Hs.654854
genes like me logo Genes that share expression patterns with COL26A1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COL26A1 Gene

Orthologs for COL26A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COL26A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COL26A1 34
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COL26A1 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Col26a1 16 34 33
  • 81.89 (n)
rat
(Rattus norvegicus)
Mammalia Col26a1 33
  • 81.89 (n)
oppossum
(Monodelphis domestica)
Mammalia COL26A1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COL26A1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMID2 33
  • 70.21 (n)
lizard
(Anolis carolinensis)
Reptilia COL26A1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia col26a1 33
  • 59.59 (n)
zebrafish
(Danio rerio)
Actinopterygii COL26A1 34
  • 56 (a)
OneToOne
Species where no ortholog for COL26A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COL26A1 Gene

ENSEMBL:
Gene Tree for COL26A1 (if available)
TreeFam:
Gene Tree for COL26A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COL26A1: view image

Paralogs for COL26A1 Gene

Paralogs for COL26A1 Gene

genes like me logo Genes that share paralogs with COL26A1: view

Variants for COL26A1 Gene

Sequence variations from dbSNP and Humsavar for COL26A1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000003096 -- 101,486,416(+) A/T intron_variant
rs1000004368 -- 101,492,141(+) G/T intron_variant
rs1000008801 -- 101,461,444(+) G/C intron_variant
rs1000013976 -- 101,437,024(+) A/G intron_variant
rs1000030185 -- 101,555,626(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COL26A1 Gene

Variant ID Type Subtype PubMed ID
dgv11535n54 CNV gain 21841781
dgv1230e199 CNV deletion 23128226
dgv1943e212 CNV gain 25503493
dgv236e55 CNV gain 17911159
dgv445e215 CNV deletion 23714750
dgv6537n100 CNV gain 25217958
dgv829n27 CNV gain 19166990
esv1000049 CNV deletion 20482838
esv1010932 CNV deletion 20482838
esv1729362 CNV deletion 17803354
esv22098 CNV loss 19812545
esv2422376 CNV duplication 17116639
esv2658057 CNV deletion 23128226
esv2663669 CNV deletion 23128226
esv2666978 CNV deletion 23128226
esv2667662 CNV deletion 23128226
esv26989 CNV loss 19812545
esv2734927 CNV deletion 23290073
esv2734929 CNV deletion 23290073
esv2734930 CNV deletion 23290073
esv2734931 CNV deletion 23290073
esv2734932 CNV deletion 23290073
esv2734933 CNV deletion 23290073
esv2752134 CNV gain 17911159
esv2761351 CNV gain 21179565
esv3277717 CNV deletion 24192839
esv3542173 CNV deletion 23714750
esv3542176 CNV deletion 23714750
esv3542177 CNV deletion 23714750
esv3542179 CNV deletion 23714750
esv3572029 CNV loss 25503493
esv3572030 CNV loss 25503493
esv3572032 CNV loss 25503493
esv3572033 CNV loss 25503493
esv3572034 CNV loss 25503493
esv3572035 CNV loss 25503493
esv3614330 CNV gain 21293372
esv3614331 CNV loss 21293372
esv3614332 CNV loss 21293372
esv3614333 CNV gain 21293372
esv3614334 CNV loss 21293372
esv3614335 CNV loss 21293372
esv3614336 CNV gain 21293372
esv3891166 CNV loss 25118596
esv999577 CNV deletion 20482838
nsv1020524 CNV gain 25217958
nsv1023393 CNV gain 25217958
nsv1025029 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv1073302 CNV deletion 25765185
nsv1109905 CNV deletion 24896259
nsv1109906 CNV deletion 24896259
nsv1110808 CNV insertion 24896259
nsv1124251 CNV deletion 24896259
nsv1161591 CNV deletion 26073780
nsv366777 CNV deletion 16902084
nsv511983 CNV loss 21212237
nsv517175 CNV gain+loss 19592680
nsv5876 CNV insertion 18451855
nsv607979 CNV loss 21841781
nsv607981 CNV gain 21841781
nsv607983 CNV loss 21841781
nsv831076 CNV loss 17160897
nsv831077 CNV loss 17160897
nsv831078 CNV loss 17160897

Variation tolerance for COL26A1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COL26A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COL26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COL26A1 Gene

Disorders for COL26A1 Gene

Additional Disease Information for COL26A1

No disorders were found for COL26A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COL26A1 Gene

Publications for COL26A1 Gene

  1. Developmental expression and biochemical characterization of Emu family members. (PMID: 12221002) Leimeister C … Gessler M (Developmental biology 2002) 2 3 4 58
  2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. (PMID: 12145293) Sato K … Nagata K (The Journal of biological chemistry 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D … Kimber SJ (The Journal of biological chemistry 2013) 3 58
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 58

Products for COL26A1 Gene

Sources for COL26A1 Gene

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