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Aliases for THEM4 Gene

Aliases for THEM4 Gene

  • Thioesterase Superfamily Member 4 2 3 4 5
  • Carboxyl-Terminal Modulator Protein 3 4
  • C-Terminal Modulator Protein 2 3
  • Acyl-CoA Thioesterase THEM4 3 4
  • CTMP 3 4
  • Acyl-Coenzyme A Thioesterase THEM4 3
  • EC 3.1.2.2 4

External Ids for THEM4 Gene

Previous GeneCards Identifiers for THEM4 Gene

  • GC01M148660
  • GC01M150112
  • GC01M151846
  • GC01M123223

Summaries for THEM4 Gene

Entrez Gene Summary for THEM4 Gene

  • Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for THEM4 Gene

THEM4 (Thioesterase Superfamily Member 4) is a Protein Coding gene. Among its related pathways are Akt Signaling and CD28 co-stimulation. Gene Ontology (GO) annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM5.

UniProtKB/Swiss-Prot for THEM4 Gene

  • Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.

Additional gene information for THEM4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEM4 Gene

Genomics for THEM4 Gene

GeneHancer (GH) Regulatory Elements for THEM4 Gene

Promoters and enhancers for THEM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J151908 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 673.2 +0.4 436 2.4 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC ZNF610 THEM4 GABPB2 PI4KB MRPL9 POGZ SETDB1 PIP5K1A ZNF687 C1orf56 TDRKH
GH01J151953 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 683.4 -44.4 -44426 2.3 SP1 ZNF664 ZNF316 MAFF HNF4A MAFK THEM4 ENSG00000229021 S100A10 LINGO4 KRT8P28 LOC105371441
GH01J151986 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.1 -84.6 -84598 16.2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ENSG00000229021 S100A10 THEM4 S100A11 THEM5 FLG-AS1 MLLT11 LOC105371441
GH01J151933 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 35.5 -25.9 -25856 3.6 HDGF RB1 KLF17 ZNF2 RAD21 RFX5 ARID2 ZNF366 SCRT2 ZNF143 THEM4 ENSG00000229021 S100A10 LINGO4 THEM5 C1orf56 GC01M151949
GH01J151940 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.7 -34.2 -34213 7.6 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B ZNF416 FOS POGZ GABPB2 PI4KB MRPL9 PIP5K1A LYSMD1 ENSG00000229021 HRNR THEM4 C1orf56
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THEM4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THEM4 gene promoter:
  • Egr-2
  • S8

Genomic Locations for THEM4 Gene

Genomic Locations for THEM4 Gene
chr1:151,870,866-151,909,885
(GRCh38/hg38)
Size:
39,020 bases
Orientation:
Minus strand
chr1:151,843,342-151,882,361
(GRCh37/hg19)
Size:
39,020 bases
Orientation:
Minus strand

Genomic View for THEM4 Gene

Genes around THEM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEM4 Gene

Proteins for THEM4 Gene

  • Protein details for THEM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1C6-THEM4_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase THEM4
    Protein Accession:
    Q5T1C6
    Secondary Accessions:
    • B2RBX2
    • Q96KR2

    Protein attributes for THEM4 Gene

    Size:
    240 amino acids
    Molecular mass:
    27130 Da
    Quaternary structure:
    • Homodimer and homotetramer. Interacts with AKT1 in the cytosol.

    Three dimensional structures from OCA and Proteopedia for THEM4 Gene

neXtProt entry for THEM4 Gene

Post-translational modifications for THEM4 Gene

Other Protein References for THEM4 Gene

No data available for DME Specific Peptides for THEM4 Gene

Domains & Families for THEM4 Gene

Gene Families for THEM4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for THEM4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T1C6

UniProtKB/Swiss-Prot:

THEM4_HUMAN :
  • Belongs to the THEM4/THEM5 thioesterase family.
Family:
  • Belongs to the THEM4/THEM5 thioesterase family.
genes like me logo Genes that share domains with THEM4: view

Function for THEM4 Gene

Molecular function for THEM4 Gene

UniProtKB/Swiss-Prot Function:
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.4 uM for myristoyl-CoA {ECO:0000269 PubMed:19453107, ECO:0000269 PubMed:22871024}; KM=2.6 uM for palmitoyl-CoA {ECO:0000269 PubMed:19453107, ECO:0000269 PubMed:22871024}; KM=5.2 uM for oleoyl-CoA {ECO:0000269 PubMed:19453107, ECO:0000269 PubMed:22871024};

Enzyme Numbers (IUBMB) for THEM4 Gene

Phenotypes From GWAS Catalog for THEM4 Gene

Gene Ontology (GO) - Molecular Function for THEM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19541650
GO:0016290 palmitoyl-CoA hydrolase activity IEA,IDA 22871024
GO:0016787 hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
GO:0102991 myristoyl-CoA hydrolase activity IEA --
genes like me logo Genes that share ontologies with THEM4: view
genes like me logo Genes that share phenotypes with THEM4: view

Animal Models for THEM4 Gene

MGI Knock Outs for THEM4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THEM4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THEM4 Gene

Localization for THEM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEM4 Gene

Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269 PubMed:19168129}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEM4 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
cytosol 5

Gene Ontology (GO) - Cellular Components for THEM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA,IEA 19604401
GO:0005743 mitochondrial inner membrane IEA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with THEM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for THEM4 Gene

Pathways & Interactions for THEM4 Gene

genes like me logo Genes that share pathways with THEM4: view

Pathways by source for THEM4 Gene

1 Qiagen pathway for THEM4 Gene
1 Cell Signaling Technology pathway for THEM4 Gene

SIGNOR curated interactions for THEM4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for THEM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IDA,IEA 22871024
GO:0006637 acyl-CoA metabolic process TAS --
GO:0006915 apoptotic process IEA --
GO:0035336 long-chain fatty-acyl-CoA metabolic process IBA --
genes like me logo Genes that share ontologies with THEM4: view

Drugs & Compounds for THEM4 Gene

(3) Drugs for THEM4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Water Approved Pharma 0
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for THEM4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
  • coenzyme A, S-Hexadecanoate
  • Palmitoyl coenzyme A
  • S-Palmitoylcoenzyme A
  • coenzyme A, S-Hexadecanoic acid
genes like me logo Genes that share compounds with THEM4: view

Transcripts for THEM4 Gene

mRNA/cDNA for THEM4 Gene

Unigene Clusters for THEM4 Gene

Thioesterase superfamily member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THEM4

Alternative Splicing Database (ASD) splice patterns (SP) for THEM4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5: -

Relevant External Links for THEM4 Gene

GeneLoc Exon Structure for
THEM4
ECgene alternative splicing isoforms for
THEM4

Expression for THEM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THEM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THEM4 Gene

This gene is overexpressed in Tlymphocyte (19.2), CD4 Tcells (9.2), Retina (6.9), Heart (6.8), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THEM4 Gene



NURSA nuclear receptor signaling pathways regulating expression of THEM4 Gene:

THEM4

SOURCE GeneReport for Unigene cluster for THEM4 Gene:

Hs.164070

mRNA Expression by UniProt/SwissProt for THEM4 Gene:

Q5T1C6-THEM4_HUMAN
Tissue specificity: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
genes like me logo Genes that share expression patterns with THEM4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for THEM4 Gene

Orthologs for THEM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEM4 34 33
  • 98.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia THEM4 34 33
  • 83.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia THEM4 34 33
  • 80.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Them4 33
  • 80.14 (n)
mouse
(Mus musculus)
Mammalia Them4 16 34 33
  • 79.71 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia them4 33
  • 55.15 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:158847 33
  • 55.44 (n)
THEM4 34
  • 39 (a)
OneToMany
Species where no ortholog for THEM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEM4 Gene

ENSEMBL:
Gene Tree for THEM4 (if available)
TreeFam:
Gene Tree for THEM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THEM4: view image

Paralogs for THEM4 Gene

Paralogs for THEM4 Gene

(1) SIMAP similar genes for THEM4 Gene using alignment to 3 proteins:

  • THEM4_HUMAN
  • E9PLJ7_HUMAN
  • F6XC58_HUMAN

Pseudogenes.org Pseudogenes for THEM4 Gene

genes like me logo Genes that share paralogs with THEM4: view

Variants for THEM4 Gene

Sequence variations from dbSNP and Humsavar for THEM4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000015132 -- 151,903,138(-) T/A intron_variant
rs1000027438 -- 151,896,362(-) G/A intron_variant
rs1000082836 -- 151,908,099(-) T/G intron_variant
rs1000199996 -- 151,909,882(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000203750 -- 151,876,298(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THEM4 Gene

Variant ID Type Subtype PubMed ID
esv3578176 CNV loss 25503493
nsv1007097 CNV gain 25217958
nsv547852 CNV loss 21841781

Variation tolerance for THEM4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THEM4 Gene

Human Gene Mutation Database (HGMD)
THEM4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEM4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEM4 Gene

Disorders for THEM4 Gene

Additional Disease Information for THEM4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for THEM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEM4 Gene

Publications for THEM4 Gene

  1. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. (PMID: 11598301) Maira SM … Hemmings BA (Science (New York, N.Y.) 2001) 2 3 4 58
  2. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. (PMID: 22871024) Zhao H … Dunaway-Mariano D (Biochemistry 2012) 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis. (PMID: 19168129) Parcellier A … Hemmings BA (Cellular signalling 2009) 3 4 58
  5. Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein. (PMID: 19604401) Piao L … Park J (BMC cell biology 2009) 3 4 58

Products for THEM4 Gene

Sources for THEM4 Gene

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