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Aliases for OR10J3 Gene

Aliases for OR10J3 Gene

  • Olfactory Receptor Family 10 Subfamily J Member 3 2 3 5
  • OR10J3P 3 4
  • Olfactory Receptor, Family 10, Subfamily J, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily J, Member 3 2
  • Olfactory Receptor OR1-25 Pseudogene 3
  • Olfactory Receptor 10J3 3
  • OR1-25 3

External Ids for OR10J3 Gene

Previous HGNC Symbols for OR10J3 Gene

  • OR10J3P

Previous GeneCards Identifiers for OR10J3 Gene

  • GC01M156500
  • GC01M156062
  • GC01M156096
  • GC01M157550

Summaries for OR10J3 Gene

Entrez Gene Summary for OR10J3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10J3 Gene

OR10J3 (Olfactory Receptor Family 10 Subfamily J Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10J1.

UniProtKB/Swiss-Prot for OR10J3 Gene

  • Odorant receptor.

Gene Wiki entry for OR10J3 Gene

Additional gene information for OR10J3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10J3 Gene

Genomics for OR10J3 Gene

GeneHancer (GH) Regulatory Elements for OR10J3 Gene

Promoters and enhancers for OR10J3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159596 Enhancer 0.9 Ensembl ENCODE 9.5 -283.3 -283315 2.7 FOXA2 JUN MAX RAD21 YY1 GATA3 EGR1 FOSL2 RXRA CEBPB OR10J6P OR10J5 OR10J3 DUSP23 SLAMF9 APCS GC01P159502
GH01J159172 Enhancer 0.9 FANTOM5 Ensembl ENCODE 9 +141.6 141575 1 SP1 ZNF143 SIN3A CTBP2 EBF1 CADM3 ACKR1 CADM3-AS1 AIM2 ENSG00000212161 OR10J3 OR6N1 OR6K3 FCER1A OR6N2
GH01J159211 Enhancer 0.7 Ensembl 9.2 +103.3 103258 0.4 CTCF ARNT CEBPG RAD21 CC2D1A ARID2 SCRT2 SMC3 ZNF143 SCRT1 CADM3 AIM2 OR10J2P FCER1A OR10J3 DUSP23 ACKR1 CADM3-AS1 MPTX1
GH01J159229 Enhancer 0.5 ENCODE 10.2 +84.8 84779 1.1 SP1 STAT1 RXRA HNF4A RCOR1 REST FCER1A CADM3-AS1 ACKR1 OR10J2P OR10J3 MPTX1
GH01J159427 Enhancer 0.4 ENCODE 10.2 -114.1 -114092 2.8 MNT MAFK OR10J3 OR10J2P FCER1A ENSG00000228560 OR10J4 OR10J9P OR10J1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR10J3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10J3 gene promoter:

Genomic Locations for OR10J3 Gene

Genomic Locations for OR10J3 Gene
chr1:159,313,670-159,314,659
(GRCh38/hg38)
Size:
990 bases
Orientation:
Minus strand
chr1:159,283,460-159,284,449
(GRCh37/hg19)

Genomic View for OR10J3 Gene

Genes around OR10J3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10J3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10J3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10J3 Gene

Proteins for OR10J3 Gene

  • Protein details for OR10J3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JRS4-O10J3_HUMAN
    Recommended name:
    Olfactory receptor 10J3
    Protein Accession:
    Q5JRS4

    Protein attributes for OR10J3 Gene

    Size:
    329 amino acids
    Molecular mass:
    36549 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10J3 Gene

Post-translational modifications for OR10J3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10J3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10J3 Gene

Domains & Families for OR10J3 Gene

Gene Families for OR10J3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10J3 Gene

Suggested Antigen Peptide Sequences for OR10J3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JRS4

UniProtKB/Swiss-Prot:

O10J3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10J3: view

Function for OR10J3 Gene

Molecular function for OR10J3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10J3 Gene

Gene Ontology (GO) - Molecular Function for OR10J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10J3: view
genes like me logo Genes that share phenotypes with OR10J3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10J3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10J3 Gene

Localization for OR10J3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10J3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10J3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10J3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10J3 Gene

Pathways & Interactions for OR10J3 Gene

genes like me logo Genes that share pathways with OR10J3: view

Pathways by source for OR10J3 Gene

Interacting Proteins for OR10J3 Gene

Gene Ontology (GO) - Biological Process for OR10J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR10J3: view

No data available for SIGNOR curated interactions for OR10J3 Gene

Drugs & Compounds for OR10J3 Gene

No Compound Related Data Available

Transcripts for OR10J3 Gene

mRNA/cDNA for OR10J3 Gene

(1) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
-
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10J3 Gene

Olfactory receptor, family 10, subfamily J, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10J3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10J3 Gene

No ASD Table

Relevant External Links for OR10J3 Gene

GeneLoc Exon Structure for
OR10J3
ECgene alternative splicing isoforms for
OR10J3

Expression for OR10J3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10J3 Gene

mRNA differential expression in normal tissues according to GTEx for OR10J3 Gene

This gene is overexpressed in Liver (x9.3), Brain - Nucleus accumbens (basal ganglia) (x5.2), and Cervix - Endocervix (x4.8).

Protein differential expression in normal tissues from HIPED for OR10J3 Gene

This gene is overexpressed in Plasma (35.7) and Neutrophil (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10J3 Gene



Protein tissue co-expression partners for OR10J3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10J3 Gene:

OR10J3

SOURCE GeneReport for Unigene cluster for OR10J3 Gene:

Hs.553833
genes like me logo Genes that share expression patterns with OR10J3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10J3 Gene

Orthologs for OR10J3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10J3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC488624 33
  • 87.83 (n)
-- 34
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or10j3 51 Olfr218 16 34 33
  • 84.04 (n)
Or10j3b 51 Olfr1404 34
  • 75 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1582 33
  • 83.8 (n)
cow
(Bos Taurus)
Mammalia OR10J3 33
  • 83.44 (n)
-- 34
  • 81 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia OR10J3 33
  • 76.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
OneToMany
Species where no ortholog for OR10J3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10J3 Gene

ENSEMBL:
Gene Tree for OR10J3 (if available)
TreeFam:
Gene Tree for OR10J3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10J3: view image

Paralogs for OR10J3 Gene

(449) SIMAP similar genes for OR10J3 Gene using alignment to 1 proteins:

  • O10J3_HUMAN

Pseudogenes.org Pseudogenes for OR10J3 Gene

genes like me logo Genes that share paralogs with OR10J3: view

Variants for OR10J3 Gene

Sequence variations from dbSNP and Humsavar for OR10J3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001328296 -- 159,315,402(-) C/T upstream_transcript_variant
rs1001383763 -- 159,315,704(-) C/T upstream_transcript_variant
rs1001602438 -- 159,315,905(-) T/C upstream_transcript_variant
rs1004617112 -- 159,314,973(-) A/T upstream_transcript_variant
rs1004690583 -- 159,314,670(-) C/A upstream_transcript_variant

Variation tolerance for OR10J3 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10J3 Gene

Human Gene Mutation Database (HGMD)
OR10J3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10J3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR10J3 Gene

Disorders for OR10J3 Gene

Additional Disease Information for OR10J3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR10J3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10J3 Gene

Publications for OR10J3 Gene

  1. Chemerin, a novel adipokine in the regulation of angiogenesis. (PMID: 20237162) Bozaoglu K … Jowett JB (The Journal of clinical endocrinology and metabolism 2010) 3 44 58
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  4. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PMID: 19372141) Lee JY … Kang D (Carcinogenesis 2009) 3 44 58
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 3 44 58

Products for OR10J3 Gene

Sources for OR10J3 Gene

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