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Aliases for ZNF528 Gene

Aliases for ZNF528 Gene

  • Zinc Finger Protein 528 2 3 3 5
  • KIAA1827 4

External Ids for ZNF528 Gene

Previous GeneCards Identifiers for ZNF528 Gene

  • GC19P057465
  • GC19P057610
  • GC19P057591
  • GC19P052901
  • GC19P049231

Summaries for ZNF528 Gene

GeneCards Summary for ZNF528 Gene

ZNF528 (Zinc Finger Protein 528) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF880.

UniProtKB/Swiss-Prot for ZNF528 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF528 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF528 Gene

Genomics for ZNF528 Gene

GeneHancer (GH) Regulatory Elements for ZNF528 Gene

Promoters and enhancers for ZNF528 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052396 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 664.2 0.0 -49 2 ARID4B ZNF48 YY1 ETS1 CBX5 RUNX3 MXD4 ZNF518A KAT8 ATF4 ZNF528 ZNF528-AS1 ZNF534 ZNF175 ZNF611 LOC100419835
GH19J051687 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.9 -707.4 -707358 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 SPACA6 ZNF137P ZNF841 ZNF808 ZNF616 ZNF766 ZNF836 ZNF577 ENSG00000268970 ENSG00000269825
GH19J051421 Enhancer 1.2 Ensembl ENCODE 18.6 -976.0 -976006 1.1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 SLC30A9 ZNF766 CBX5 ZNF528 ZNF175 ZNF614 ZNF615 ENSG00000269483 LOC100419835 ZNF432 ENSG00000268711 SIGLEC10
GH19J052569 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.1 +172.4 172442 2.2 HDGF ATF1 SMAD1 ARNT ARID4B SIN3A ZNF48 ETS1 POLR2B E2F8 ZNF701 ZNF613 ZNF137P ENSG00000268970 ZNF611 ZNF175 ENSG00000269001 TPM3P9 ZNF665 ZNF525
GH19J052598 Enhancer 1.1 Ensembl ENCODE 11 +202.8 202760 4.1 HDGF PKNOX1 ARID4B SIN3A ZNF48 YY1 POLR2B ARID2 ZNF143 SP3 ENSG00000268970 SPACA6P-AS ZNF528 ZNF137P ZNF83 ENSG00000269349 PIR60713 ENSG00000269825
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF528 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF528 gene promoter:
  • Ik-1
  • AREB6

Genomic Locations for ZNF528 Gene

Genomic Locations for ZNF528 Gene
chr19:52,397,849-52,418,412
(GRCh38/hg38)
Size:
20,564 bases
Orientation:
Plus strand
chr19:52,901,102-52,921,665
(GRCh37/hg19)
Size:
20,564 bases
Orientation:
Plus strand

Genomic View for ZNF528 Gene

Genes around ZNF528 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF528 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF528 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF528 Gene

Proteins for ZNF528 Gene

  • Protein details for ZNF528 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIS6-ZN528_HUMAN
    Recommended name:
    Zinc finger protein 528
    Protein Accession:
    Q3MIS6
    Secondary Accessions:
    • B3KPN4
    • Q86T88
    • Q96JK0

    Protein attributes for ZNF528 Gene

    Size:
    628 amino acids
    Molecular mass:
    72138 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47456.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF528 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF528 Gene

Post-translational modifications for ZNF528 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF528 Gene

Domains & Families for ZNF528 Gene

Gene Families for ZNF528 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF528 Gene

Suggested Antigen Peptide Sequences for ZNF528 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3MIS6

UniProtKB/Swiss-Prot:

ZN528_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF528: view

Function for ZNF528 Gene

Molecular function for ZNF528 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF528 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF528: view
genes like me logo Genes that share phenotypes with ZNF528: view

Animal Model Products

Targeted motifs for ZNF528 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF528
  • Consensus sequence: AGAAATGACTTCCCT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF528 Gene

Localization for ZNF528 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF528 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF528 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF528 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF528: view

Pathways & Interactions for ZNF528 Gene

SuperPathways for ZNF528 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF528: view

Pathways by source for ZNF528 Gene

2 Reactome pathways for ZNF528 Gene

Gene Ontology (GO) - Biological Process for ZNF528 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF528: view

No data available for SIGNOR curated interactions for ZNF528 Gene

Drugs & Compounds for ZNF528 Gene

No Compound Related Data Available

Transcripts for ZNF528 Gene

Unigene Clusters for ZNF528 Gene

Zinc finger protein 528:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF528 Gene

No ASD Table

Relevant External Links for ZNF528 Gene

GeneLoc Exon Structure for
ZNF528
ECgene alternative splicing isoforms for
ZNF528

Expression for ZNF528 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF528 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF528 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF528 Gene:

ZNF528

SOURCE GeneReport for Unigene cluster for ZNF528 Gene:

Hs.662043

Evidence on tissue expression from TISSUES for ZNF528 Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with ZNF528: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF528 Gene

Orthologs for ZNF528 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF528 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF528 33
  • 99.15 (n)
-- 34
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea Cin.921 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.921 33
Species where no ortholog for ZNF528 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF528 Gene

ENSEMBL:
Gene Tree for ZNF528 (if available)
TreeFam:
Gene Tree for ZNF528 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF528: view image

Paralogs for ZNF528 Gene

Paralogs for ZNF528 Gene

(511) SIMAP similar genes for ZNF528 Gene using alignment to 7 proteins:

  • ZN528_HUMAN
  • C9JLS3_HUMAN
  • C9K0H2_HUMAN
  • F8WAL3_HUMAN
  • J3KQN0_HUMAN
  • M0QXZ2_HUMAN
  • M0QZG9_HUMAN

Pseudogenes.org Pseudogenes for ZNF528 Gene

genes like me logo Genes that share paralogs with ZNF528: view

Variants for ZNF528 Gene

Sequence variations from dbSNP and Humsavar for ZNF528 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000048331 -- 52,407,435(+) C/T intron_variant
rs1000066948 -- 52,400,397(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000137941 -- 52,397,623(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000230105 -- 52,413,160(+) C/T intron_variant
rs1000240560 -- 52,418,359(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF528 Gene

Variant ID Type Subtype PubMed ID
esv2762048 CNV loss 21179565
esv33518 CNV gain 17666407
esv3644693 CNV loss 21293372
esv3644695 CNV loss 21293372
nsv1114029 CNV deletion 24896259
nsv1138724 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv2536 CNV deletion 18451855
nsv521079 CNV loss 19592680
nsv828615 CNV loss 20364138
nsv833873 CNV gain 17160897
nsv978840 CNV duplication 23825009

Variation tolerance for ZNF528 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF528 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF528

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF528 Gene

Disorders for ZNF528 Gene

Additional Disease Information for ZNF528

No disorders were found for ZNF528 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF528 Gene

Publications for ZNF528 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF528 Gene

Sources for ZNF528 Gene

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