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Aliases for SERINC3 Gene

Aliases for SERINC3 Gene

  • Serine Incorporator 3 2 3 3 5
  • Tumor Differentially Expressed Protein 1 3 4
  • DIFF33 3 4
  • TDE1 3 4
  • Tumor Differentially Expressed 1 2
  • SBBI99 3
  • AIGP1 3
  • TMS-1 3
  • TDE 3

External Ids for SERINC3 Gene

Previous HGNC Symbols for SERINC3 Gene

  • TDE1

Previous GeneCards Identifiers for SERINC3 Gene

  • GC20M042559
  • GC20M043124
  • GC20M039866

Summaries for SERINC3 Gene

GeneCards Summary for SERINC3 Gene

SERINC3 (Serine Incorporator 3) is a Protein Coding gene. Diseases associated with SERINC3 include Carbuncle. Among its related pathways are Metabolism and Amino acid synthesis and interconversion (transamination). Gene Ontology (GO) annotations related to this gene include L-serine transmembrane transporter activity. An important paralog of this gene is SERINC1.

UniProtKB/Swiss-Prot for SERINC3 Gene

  • Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Gene Wiki entry for SERINC3 Gene

Additional gene information for SERINC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERINC3 Gene

Genomics for SERINC3 Gene

GeneHancer (GH) Regulatory Elements for SERINC3 Gene

Promoters and enhancers for SERINC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044518 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.8 +0.7 735 4.8 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SERINC3 PKIG TTPAL PIR36658 GC20M044500
GH20J044690 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -171.9 -171934 6.4 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A SLC30A9 ZNF143 FOS DEK ENSG00000132832 WISP2 KCNK15 KCNK15-AS1 ADA SERINC3 PKIG PIGT PABPC1L LINC01260
GH20J044493 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 13.2 +26.2 26154 4.8 PKNOX1 BATF IRF4 SCRT2 ATF7 FOS RUNX3 CREM RXRA JUNB GC20P044495 PIR46342 PKIG TTPAL SERINC3 RPL37AP1 LINC01430 LINC01620 OSER1 ADA
GH20J044594 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -72.7 -72723 1.3 EBF1 BATF ZNF644 RELA FOSL1 TCF12 CTBP1 EED CBFA2T2 FOS PKIG SERINC3 ADA LINC01620 LINC01430 TTPAL PIR61280 GC20M044554
GH20J044683 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 -162.6 -162602 2.5 SIN3A ZNF48 YY1 SLC30A9 ELK1 ARID2 ZNF143 RUNX3 DEK RXRA ENSG00000132832 ADA KCNK15 WISP2 KCNK15-AS1 SERINC3 PKIG OSER1-DT LINC01260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SERINC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SERINC3 gene promoter:
  • Ik-1
  • AREB6
  • LCR-F1
  • LUN-1
  • Elk-1
  • E2F
  • E2F-1
  • MZF-1
  • Pax-4a

Genomic Locations for SERINC3 Gene

Genomic Locations for SERINC3 Gene
chr20:44,496,221-44,522,109
(GRCh38/hg38)
Size:
25,889 bases
Orientation:
Minus strand
chr20:43,124,862-43,150,750
(GRCh37/hg19)
Size:
25,889 bases
Orientation:
Minus strand

Genomic View for SERINC3 Gene

Genes around SERINC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERINC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERINC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERINC3 Gene

Proteins for SERINC3 Gene

  • Protein details for SERINC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13530-SERC3_HUMAN
    Recommended name:
    Serine incorporator 3
    Protein Accession:
    Q13530
    Secondary Accessions:
    • B4DUE9
    • O43717
    • Q9BR33

    Protein attributes for SERINC3 Gene

    Size:
    473 amino acids
    Molecular mass:
    52580 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB48858.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305}; Sequence=AAD34641.1; Type=Frameshift; Positions=321, 393, 407, 459; Evidence={ECO:0000305};

    Alternative splice isoforms for SERINC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SERINC3 Gene

Post-translational modifications for SERINC3 Gene

Other Protein References for SERINC3 Gene

No data available for DME Specific Peptides for SERINC3 Gene

Domains & Families for SERINC3 Gene

Gene Families for SERINC3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SERINC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q13530

UniProtKB/Swiss-Prot:

SERC3_HUMAN :
  • Belongs to the TDE1 family.
Family:
  • Belongs to the TDE1 family.
genes like me logo Genes that share domains with SERINC3: view

Function for SERINC3 Gene

Molecular function for SERINC3 Gene

UniProtKB/Swiss-Prot Function:
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Phenotypes From GWAS Catalog for SERINC3 Gene

Gene Ontology (GO) - Molecular Function for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015194 L-serine transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SERINC3: view
genes like me logo Genes that share phenotypes with SERINC3: view

Animal Models for SERINC3 Gene

MGI Knock Outs for SERINC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERINC3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERINC3 Gene

Localization for SERINC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERINC3 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Cytoplasm, perinuclear region. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (Probable). {ECO:0000305 PubMed:26416734}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SERINC3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
extracellular 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA,IEA --
genes like me logo Genes that share ontologies with SERINC3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SERINC3 Gene

Pathways & Interactions for SERINC3 Gene

genes like me logo Genes that share pathways with SERINC3: view

Gene Ontology (GO) - Biological Process for SERINC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006564 L-serine biosynthetic process TAS --
GO:0006658 phosphatidylserine metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0009597 detection of virus IDA 26416733
genes like me logo Genes that share ontologies with SERINC3: view

No data available for SIGNOR curated interactions for SERINC3 Gene

Drugs & Compounds for SERINC3 Gene

No Compound Related Data Available

Transcripts for SERINC3 Gene

mRNA/cDNA for SERINC3 Gene

Unigene Clusters for SERINC3 Gene

Serine incorporator 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERINC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for SERINC3 Gene

GeneLoc Exon Structure for
SERINC3
ECgene alternative splicing isoforms for
SERINC3

Expression for SERINC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SERINC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SERINC3 Gene

This gene is overexpressed in Placenta (20.7), Testis (14.7), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SERINC3 Gene



Protein tissue co-expression partners for SERINC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SERINC3 Gene:

SERINC3

SOURCE GeneReport for Unigene cluster for SERINC3 Gene:

Hs.272168

mRNA Expression by UniProt/SwissProt for SERINC3 Gene:

Q13530-SERC3_HUMAN
Tissue specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Evidence on tissue expression from TISSUES for SERINC3 Gene

  • Nervous system(4.9)
  • Pancreas(4.3)
  • Lung(3.6)
  • Liver(3.5)
  • Heart(3.1)
  • Kidney(2.7)
  • Muscle(2.7)
  • Blood(2.3)
  • Skin(2.3)
  • Intestine(2.1)
  • Stomach(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SERINC3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SERINC3 Gene

Orthologs for SERINC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERINC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERINC3 34 33
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SERINC3 34 33
  • 87.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SERINC3 34 33
  • 84.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Serinc3 16 34 33
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Serinc3 33
  • 80.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SERINC3 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SERINC3 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves SERINC3 34 33
  • 70.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SERINC3 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia serinc3 33
  • 66.81 (n)
Str.1226 33
zebrafish
(Danio rerio)
Actinopterygii LOC100535683 33
  • 61.92 (n)
SERINC3 34
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TMS1 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11H6.2 34
  • 43 (a)
ManyToMany
Y57E12AL.1 34
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMS1 36 34
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16180 33
  • 48.05 (n)
rice
(Oryza sativa)
Liliopsida Os02g0792900 33
  • 48.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
ManyToMany
-- 34
  • 49 (a)
ManyToMany
Species where no ortholog for SERINC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SERINC3 Gene

ENSEMBL:
Gene Tree for SERINC3 (if available)
TreeFam:
Gene Tree for SERINC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SERINC3: view image

Paralogs for SERINC3 Gene

Paralogs for SERINC3 Gene

(4) SIMAP similar genes for SERINC3 Gene using alignment to 5 proteins:

  • SERC3_HUMAN
  • B4DUE9_HUMAN
  • L8E9G1_HUMAN
  • L8ECD5_HUMAN
  • Q5H936_HUMAN

Pseudogenes.org Pseudogenes for SERINC3 Gene

genes like me logo Genes that share paralogs with SERINC3: view

Variants for SERINC3 Gene

Sequence variations from dbSNP and Humsavar for SERINC3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000174768 -- 44,513,250(-) C/A intron_variant
rs1000245326 -- 44,523,000(-) G/A upstream_transcript_variant
rs1000255314 -- 44,508,252(-) G/A intron_variant
rs1000283629 -- 44,517,069(-) T/C intron_variant
rs1000289603 -- 44,504,530(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SERINC3 Gene

Variant ID Type Subtype PubMed ID
nsv1061719 CNV gain 25217958
nsv586065 CNV gain 21841781

Variation tolerance for SERINC3 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SERINC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SERINC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERINC3 Gene

Disorders for SERINC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SERINC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carbuncle
  • carbuncle and furuncle of any part of face except eye
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SERINC3

genes like me logo Genes that share disorders with SERINC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERINC3 Gene

Publications for SERINC3 Gene

  1. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. (PMID: 10559794) Bossolasco M … Mes-Masson AM (Molecular carcinogenesis 1999) 2 3 4 58
  2. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. (PMID: 26416733) Usami Y … Göttlinger HG (Nature 2015) 3 4 58
  3. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. (PMID: 26416734) Rosa A … Pizzato M (Nature 2015) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for SERINC3 Gene

Sources for SERINC3 Gene

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