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Aliases for PPP2R5C Gene

Aliases for PPP2R5C Gene

  • Protein Phosphatase 2 Regulatory Subunit B'Gamma 2 3
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Gamma Isoform 2 3
  • Renal Carcinoma Antigen NY-REN-29 3 4
  • PP2A B Subunit Isoform PR61-Gamma 3 4
  • PP2A B Subunit Isoform B56-Gamma 3 4
  • PP2A B Subunit Isoform R5-Gamma 3 4
  • PP2A B Subunit Isoform B-Gamma 3 4
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Gamma Isoform 3
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma Isoform 3
  • Protein Phosphatase 2 Regulatory Subunit B, Gamma 3
  • Protein Phosphatase 2 Regulatory Subunit Bgamma 5
  • B Alpha Regulatory Subunit 3
  • B56gamma 3
  • KIAA0044 4
  • PR61G 3
  • B56G 3

External Ids for PPP2R5C Gene

Previous GeneCards Identifiers for PPP2R5C Gene

  • GC14P099667
  • GC14P096091
  • GC14P100219
  • GC14P100266
  • GC14P101345
  • GC14P101298
  • GC14P102228
  • GC14P082408
  • GC14P101884
  • GC14P101907
  • GC14P102218
  • GC14P102385
  • GC14P102563
  • GC14P102735
  • GC14P102905
  • GC14P103081

Summaries for PPP2R5C Gene

Entrez Gene Summary for PPP2R5C Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R5C Gene

PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) is a Protein Coding gene. Diseases associated with PPP2R5C include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3. Among its related pathways are ERK Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot for PPP2R5C Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.

Gene Wiki entry for PPP2R5C Gene

Additional gene information for PPP2R5C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5C Gene

Genomics for PPP2R5C Gene

GeneHancer (GH) Regulatory Elements for PPP2R5C Gene

Promoters and enhancers for PPP2R5C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101807 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.8 +58.7 58729 22.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 PPP2R5C WDR20 DYNC1H1 ENSG00000258919 ENSG00000259088 ENSG00000256705
GH14J101760 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 660.8 +0.8 847 2.8 HDGF CLOCK FOXA2 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B ZNF766 PPP2R5C ENSG00000258919 LINC00239 WDR20 HSP90AA1 GC14P103465
GH14J101705 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -53.1 -53063 3.8 PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ETS1 POLR2B PPP2R5C MEG9 RPL26P4 ENSG00000258919 LINC00239 WDR20 LINC02320
GH14J101962 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 +204.3 204316 6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF143 FOS DYNC1H1 HSP90AA1 PPP2R5C WDR20 ZNF839 ENSG00000259013
GH14J101713 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 20.2 -44.3 -44283 5.2 HDAC1 PKNOX1 ATF1 NFRKB POLR2B SCRT2 ZFP91 ATF7 SMAD5 REST PPP2R5C ENSG00000258919 LINC00239 LINC02320 RPL26P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP2R5C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R5C gene promoter:

Genomic Locations for PPP2R5C Gene

Genomic Locations for PPP2R5C Gene
chr14:101,760,573-101,927,992
(GRCh38/hg38)
Size:
167,420 bases
Orientation:
Plus strand
chr14:102,228,135-102,394,329
(GRCh37/hg19)

Genomic View for PPP2R5C Gene

Genes around PPP2R5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5C Gene

Proteins for PPP2R5C Gene

  • Protein details for PPP2R5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13362-2A5G_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    Protein Accession:
    Q13362
    Secondary Accessions:
    • B4DYJ8
    • B5BUA5
    • F5GWP3
    • Q14391
    • Q15060
    • Q15174
    • Q6ZN33

    Protein attributes for PPP2R5C Gene

    Size:
    524 amino acids
    Molecular mass:
    61061 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGO1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation. Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209).
    SequenceCaution:
    • Sequence=AAC50387.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG63760.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPP2R5C Gene

    Alternative splice isoforms for PPP2R5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5C Gene

Post-translational modifications for PPP2R5C Gene

  • Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
  • Ubiquitination at Lys6
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP2R5C Gene

Domains & Families for PPP2R5C Gene

Protein Domains for PPP2R5C Gene

Graphical View of Domain Structure for InterPro Entry

Q13362

UniProtKB/Swiss-Prot:

2A5G_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5C: view

Function for PPP2R5C Gene

Molecular function for PPP2R5C Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon DNA damage.
GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 gamma isoform,expressed in cardiac and skeletal muscle

Phenotypes From GWAS Catalog for PPP2R5C Gene

Gene Ontology (GO) - Molecular Function for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 1328865
GO:0008233 peptidase activity IDA --
GO:0019888 protein phosphatase regulator activity NAS 8703017
genes like me logo Genes that share ontologies with PPP2R5C: view
genes like me logo Genes that share phenotypes with PPP2R5C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R5C Gene

Localization for PPP2R5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5C Gene

Nucleus. Chromosome, centromere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R5C gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex NAS 8703017
GO:0000775 chromosome, centromeric region IEA,IDA 16580887
GO:0005634 nucleus IEA,IDA 8703017
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2R5C: view

Pathways & Interactions for PPP2R5C Gene

SuperPathways for PPP2R5C Gene

SuperPathway Contained pathways
1 RET signaling
2 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
3 PI3K/AKT activation
4 Beta-Adrenergic Signaling
5 p70S6K Signaling
genes like me logo Genes that share pathways with PPP2R5C: view

SIGNOR curated interactions for PPP2R5C Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8703017
GO:0008285 negative regulation of cell proliferation IDA 17245430
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
GO:0016485 protein processing IDA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 16717086
genes like me logo Genes that share ontologies with PPP2R5C: view

Drugs & Compounds for PPP2R5C Gene

(2) Drugs for PPP2R5C Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid Experimental Pharma Target 0
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with PPP2R5C: view

Transcripts for PPP2R5C Gene

Unigene Clusters for PPP2R5C Gene

Protein phosphatase 2, regulatory subunit B, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP2R5C Gene

GeneLoc Exon Structure for
PPP2R5C
ECgene alternative splicing isoforms for
PPP2R5C

Expression for PPP2R5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5C Gene

This gene is overexpressed in Breast (14.1), Peripheral blood mononuclear cells (11.7), Brain (8.7), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R5C Gene



Protein tissue co-expression partners for PPP2R5C Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP2R5C Gene:

PPP2R5C

SOURCE GeneReport for Unigene cluster for PPP2R5C Gene:

Hs.368264

mRNA Expression by UniProt/SwissProt for PPP2R5C Gene:

Q13362-2A5G_HUMAN
Tissue specificity: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.

Evidence on tissue expression from TISSUES for PPP2R5C Gene

  • Nervous system(4.9)
  • Bone marrow(4.3)
  • Eye(4.2)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with PPP2R5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R5C Gene

Orthologs for PPP2R5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5C 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r5c 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R5C 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5C 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R5C 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R5C 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R5C 34
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R5C 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76127 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11152 33
zebrafish
(Danio rerio)
Actinopterygii ppp2r5cb 34
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta PP2A-B' 35
  • 79 (a)
BcDNA:LD34343 35
  • 73 (a)
PP2A-B 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W08G11.4 35
  • 66 (a)
C13G3.3b 35
  • 64 (a)
C13G3.3a 35
  • 64 (a)
pptr-2 34
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 36 34
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G25510 33
  • 54.87 (n)
rice
(Oryza sativa)
Liliopsida Os05g0555100 33
  • 57.1 (n)
Os.27452 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2648 34
  • 61 (a)
OneToMany
Cin.3438 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3438 33
Species where no ortholog for PPP2R5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R5C Gene

ENSEMBL:
Gene Tree for PPP2R5C (if available)
TreeFam:
Gene Tree for PPP2R5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R5C: view image

Paralogs for PPP2R5C Gene

Paralogs for PPP2R5C Gene

(23) SIMAP similar genes for PPP2R5C Gene using alignment to 17 proteins:

  • 2A5G_HUMAN
  • G3V292_HUMAN
  • G3V2U3_HUMAN
  • G3V5T2_HUMAN
  • H0YJ12_HUMAN
  • H0YJ35_HUMAN
  • H0YJ49_HUMAN
  • H0YJ75_HUMAN
  • H0YJU0_HUMAN
  • H0YJZ3_HUMAN
  • H0YK25_HUMAN
  • H0YK26_HUMAN
  • H0YN58_HUMAN
  • H0YN84_HUMAN
  • H0YNJ3_HUMAN
  • H0YNR8_HUMAN
  • Q96B13_HUMAN

Pseudogenes.org Pseudogenes for PPP2R5C Gene

genes like me logo Genes that share paralogs with PPP2R5C: view

Variants for PPP2R5C Gene

Sequence variations from dbSNP and Humsavar for PPP2R5C Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs193920829 uncertain-significance, Malignant tumor of prostate 101,893,025(+) C/G coding_sequence_variant, missense_variant
rs869320755 uncertain-significance, not provided 101,882,240(+) CAAC/C coding_sequence_variant, inframe_deletion
rs1000007215 -- 101,814,116(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000020103 -- 101,853,262(+) AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA intron_variant
rs1000051801 -- 101,876,422(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5C Gene

Variant ID Type Subtype PubMed ID
dgv1137n106 CNV deletion 24896259
dgv1138n106 CNV deletion 24896259
esv2565595 CNV insertion 19546169
esv2656703 CNV deletion 23128226
esv2749146 CNV deletion 23290073
esv2749147 CNV deletion 23290073
esv3552066 CNV deletion 23714750
esv3568442 CNV gain 25503493
esv3581408 CNV loss 25503493
esv3635536 CNV loss 21293372
esv3635537 CNV gain 21293372
nsv1038990 CNV gain 25217958
nsv1069820 CNV deletion 25765185
nsv1070239 CNV deletion 25765185
nsv1070658 CNV deletion 25765185
nsv1113672 CNV deletion 24896259
nsv1131076 CNV deletion 24896259
nsv1136182 CNV deletion 24896259
nsv512375 CNV loss 21212237
nsv518045 CNV loss 19592680
nsv84885 CNV deletion 16902084
nsv952250 CNV deletion 24416366
nsv952251 CNV deletion 24416366
nsv974372 CNV duplication 23825009

Variation tolerance for PPP2R5C Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R5C Gene

Human Gene Mutation Database (HGMD)
PPP2R5C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5C Gene

Disorders for PPP2R5C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2R5C Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP2R5C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPP2R5C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5C Gene

Publications for PPP2R5C Gene

  1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B … Virshup DM (The Journal of biological chemistry 1995) 2 3 4 58
  2. Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. (PMID: 28174209) Wang J … Westermarck J (EMBO reports 2017) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. A genome-wide scan for common alleles affecting risk for autism. (PMID: 20663923) Anney R … Hallmayer J (Human molecular genetics 2010) 3 44 58
  5. Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. (PMID: 17967874) Shouse GP … Liu X (Molecular and cellular biology 2008) 3 4 58

Products for PPP2R5C Gene

Sources for PPP2R5C Gene