Aliases for PDE1B Gene
External Ids for PDE1B Gene
Previous HGNC Symbols for PDE1B Gene
Previous GeneCards Identifiers for PDE1B Gene
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PDE1B Gene
PDE1B (Phosphodiesterase 1B) is a Protein Coding gene. Among its related pathways are DAG and IP3 signaling and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calmodulin binding and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE1A.
UniProtKB/Swiss-Prot for PDE1B Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.