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Aliases for UBE2B Gene

Aliases for UBE2B Gene

  • Ubiquitin Conjugating Enzyme E2 B 2 3 5
  • Ubiquitin-Conjugating Enzyme E2B (RAD6 Homolog) 2 3
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 3 4
  • E2 Ubiquitin-Conjugating Enzyme B 3 4
  • Ubiquitin Carrier Protein B 3 4
  • Ubiquitin-Protein Ligase B 3 4
  • RAD6 Homolog B 3 4
  • HHR6B 3 4
  • RAD6B 3 4
  • HR6B 3 4
  • Ubiquitin-Conjugating Enzyme E2 B 3
  • Ubiquitin Conjugating Enzyme E2B 3
  • Ubiquitin-Conjugating Enzyme E2B 2
  • EC 2.3.2.23 4
  • E2 Protein 3
  • E2-17kDa 3
  • UBC2 3

External Ids for UBE2B Gene

Previous GeneCards Identifiers for UBE2B Gene

  • GC05P133355
  • GC05P134221
  • GC05P133737
  • GC05P133783
  • GC05P133734
  • GC05P133706
  • GC05P128891

Summaries for UBE2B Gene

Entrez Gene Summary for UBE2B Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2B Gene

UBE2B (Ubiquitin Conjugating Enzyme E2 B) is a Protein Coding gene. Diseases associated with UBE2B include Halothane Hepatitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2A.

UniProtKB/Swiss-Prot for UBE2B Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11-, as well as Lys-48- and Lys-63-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. May be involved in neurite outgrowth.

Gene Wiki entry for UBE2B Gene

Additional gene information for UBE2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2B Gene

Genomics for UBE2B Gene

GeneHancer (GH) Regulatory Elements for UBE2B Gene

Promoters and enhancers for UBE2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J134369 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 408 3.6 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC UBE2B ENSG00000273345 CDKL3 C5orf15 DDX46 SKP1 JADE2 SEC24A ENSG00000248559 C5orf66
GH05J134546 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +180.9 180883 10.1 HDGF PKNOX1 ARNT SIN3A YBX1 ZBTB7B ZNF207 ZNF143 FOS DEK DDX46 SEC24A C5orf66 CAMLG PPP2CA JADE2 CATSPER3 UBE2B TXNDC15 CDKL3
GH05J134113 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 -240.7 -240650 34.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 ZNF2 IRF4 TCF7 VDAC1 SKP1 CDKL3 MTND4LP30 JADE2 CDKN2AIPNL SAR1B UBE2B PPP2CA
GH05J134561 Enhancer 0.8 ENCODE dbSUPER 4.8 +190.7 190693 1.3 CTCF STAT1 JUN MAFG RAD21 NR2F2 ZNF316 NFIC SMC3 NFE2 JADE2 UBE2B GC05M134578 GC05M134520
GH05J134249 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -121.2 -121176 1.7 PKNOX1 ATF1 TCF12 ZNF766 E2F8 ATF7 KLF13 ATF4 SMARCA4 MYNN DDX46 C5orf66 SKP1 SEC24A PPP2CA UBE2B RPS13P6 ENSG00000270177 CDKL3 ENSG00000273345
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBE2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2B gene promoter:
  • Sp1
  • GR-alpha
  • GR
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP-TF
  • COUP
  • ARP-1

Genomic Locations for UBE2B Gene

Genomic Locations for UBE2B Gene
chr5:134,371,176-134,392,108
(GRCh38/hg38)
Size:
20,933 bases
Orientation:
Plus strand
chr5:133,706,870-133,727,799
(GRCh37/hg19)
Size:
20,930 bases
Orientation:
Plus strand

Genomic View for UBE2B Gene

Genes around UBE2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2B Gene

Proteins for UBE2B Gene

  • Protein details for UBE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63146-UBE2B_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 B
    Protein Accession:
    P63146
    Secondary Accessions:
    • B2R503
    • D3DQA2
    • P23567
    • Q4PJ15
    • Q9D0J6

    Protein attributes for UBE2B Gene

    Size:
    152 amino acids
    Molecular mass:
    17312 Da
    Quaternary structure:
    • Interacts with RAD18, UBR2 and WAC.

    Three dimensional structures from OCA and Proteopedia for UBE2B Gene

neXtProt entry for UBE2B Gene

Post-translational modifications for UBE2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2B Gene

No data available for DME Specific Peptides for UBE2B Gene

Domains & Families for UBE2B Gene

Gene Families for UBE2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2B Gene

Suggested Antigen Peptide Sequences for UBE2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63146

UniProtKB/Swiss-Prot:

UBE2B_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2B: view

Function for UBE2B Gene

Molecular function for UBE2B Gene

UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11-, as well as Lys-48- and Lys-63-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. May be involved in neurite outgrowth.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2B,involved in post replication repair,containing a CGG repeat in 5utr

Enzyme Numbers (IUBMB) for UBE2B Gene

Phenotypes From GWAS Catalog for UBE2B Gene

Gene Ontology (GO) - Molecular Function for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 18339854
GO:0005515 protein binding IPI 12776193
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0019787 ubiquitin-like protein transferase activity IBA --
genes like me logo Genes that share ontologies with UBE2B: view
genes like me logo Genes that share phenotypes with UBE2B: view

Animal Models for UBE2B Gene

MGI Knock Outs for UBE2B:
  • Ube2b Ube2b<tm1b(EUCOMM)Wtsi>
  • Ube2b Ube2b<tm1Jhjh>
  • Ube2b Ube2b<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for UBE2B Gene

miRTarBase miRNAs that target UBE2B

Clone Products

  • Addgene plasmids for UBE2B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2B Gene

Localization for UBE2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2B Gene

Cell membrane. Nucleus. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250 UniProtKB:P63149}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2B gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISS,IEA --
GO:0000790 nuclear chromatin IEA --
GO:0001741 XY body IEA --
GO:0005634 nucleus IDA,IEA 18339854
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with UBE2B: view

Pathways & Interactions for UBE2B Gene

genes like me logo Genes that share pathways with UBE2B: view

Pathways by source for UBE2B Gene

1 R&D Systems pathway for UBE2B Gene
1 Cell Signaling Technology pathway for UBE2B Gene

UniProtKB/Swiss-Prot P63146-UBE2B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IMP 18339854
GO:0001701 in utero embryonic development IEA --
GO:0006281 DNA repair IGI 1717990
GO:0006301 postreplication repair NAS 1559696
GO:0006344 maintenance of chromatin silencing IEA --
genes like me logo Genes that share ontologies with UBE2B: view

No data available for SIGNOR curated interactions for UBE2B Gene

Drugs & Compounds for UBE2B Gene

(5) Drugs for UBE2B Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
TZ9 Pharma 0

(1) Additional Compounds for UBE2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(1) ApexBio Compounds for UBE2B Gene

Compound Action Cas Number
TZ9 1002789-86-7
genes like me logo Genes that share compounds with UBE2B: view

Drug Products

Transcripts for UBE2B Gene

mRNA/cDNA for UBE2B Gene

Unigene Clusters for UBE2B Gene

Ubiquitin-conjugating enzyme E2B:
Representative Sequences:

Clone Products

  • Addgene plasmids for UBE2B

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -

Relevant External Links for UBE2B Gene

GeneLoc Exon Structure for
UBE2B
ECgene alternative splicing isoforms for
UBE2B

Expression for UBE2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2B Gene

This gene is overexpressed in Urine (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBE2B Gene



NURSA nuclear receptor signaling pathways regulating expression of UBE2B Gene:

UBE2B

SOURCE GeneReport for Unigene cluster for UBE2B Gene:

Hs.612096

Evidence on tissue expression from TISSUES for UBE2B Gene

  • Nervous system(4.8)
  • Bone marrow(4.4)
  • Lung(2.4)
  • Heart(2.1)
  • Muscle(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with UBE2B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2B Gene

Orthologs for UBE2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2B 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2B 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2B 34 33
  • 98.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2B 34 33
  • 97.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2b 16 34 33
  • 95.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2B 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2b 33
  • 92.32 (n)
chicken
(Gallus gallus)
Aves LOC100857678 33
  • 87.39 (n)
UBE2B 34
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2B 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2b 33
  • 85.75 (n)
Str.11129 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17466 33
zebrafish
(Danio rerio)
Actinopterygii ube2b 34 33
  • 76.54 (n)
ManyToMany
wufc79h10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9365 33
fruit fly
(Drosophila melanogaster)
Insecta UbcD6 34 35
  • 86 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-1 34 35
  • 67 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05632g 33
  • 64.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 34 33
  • 63.6 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR156C 33
  • 57.24 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7559 33
barley
(Hordeum vulgare)
Liliopsida Hv.679 33
corn
(Zea mays)
Liliopsida Zm.3859 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6239 34
  • 80 (a)
OneToMany
Cin.6140 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp6 33
  • 63.31 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09731 33
  • 61.15 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6140 33
Species where no ortholog for UBE2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2B Gene

ENSEMBL:
Gene Tree for UBE2B (if available)
TreeFam:
Gene Tree for UBE2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for UBE2B: view image

Paralogs for UBE2B Gene

Paralogs for UBE2B Gene

(37) SIMAP similar genes for UBE2B Gene using alignment to 4 proteins:

  • UBE2B_HUMAN
  • D6RDW8_HUMAN
  • H0Y9V2_HUMAN
  • H0YA80_HUMAN
genes like me logo Genes that share paralogs with UBE2B: view

Variants for UBE2B Gene

Sequence variations from dbSNP and Humsavar for UBE2B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs367537996 not-provided, not provided 134,371,618(+) G/C coding_sequence_variant, missense_variant
rs1000090740 -- 134,370,530(+) C/A upstream_transcript_variant
rs1000179830 -- 134,385,972(+) C/T intron_variant
rs1000191349 -- 134,371,377(+) C/G 5_prime_UTR_variant
rs1000199793 -- 134,371,197(+) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2B Gene

Variant ID Type Subtype PubMed ID
esv8462 CNV gain 19470904

Variation tolerance for UBE2B Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2B Gene

Human Gene Mutation Database (HGMD)
UBE2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2B Gene

Disorders for UBE2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2B Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
halothane hepatitis
  • hepatitis halothane
- elite association - COSMIC cancer census association via MalaCards
Search UBE2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UBE2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with UBE2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2B Gene

Publications for UBE2B Gene

  1. The human RAD18 gene product interacts with HHR6A and HHR6B. (PMID: 10908344) Xin H … Wang Z (Nucleic acids research 2000) 3 4 22 58
  2. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (PMID: 1559696) Koken MH … Hoeijmakers JH (Genomics 1992) 2 3 22 58
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 58
  4. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 44 58
  5. Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. (PMID: 18363965) Tsuji Y … Tateishi S (Genes to cells : devoted to molecular & cellular mechanisms 2008) 3 22 58

Products for UBE2B Gene

  • Addgene plasmids for UBE2B

Sources for UBE2B Gene

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