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Aliases for YPEL5 Gene

Aliases for YPEL5 Gene

  • Yippee Like 5 2 3 5
  • Yippee-Like 5 (Drosophila) 2
  • Protein Yippee-Like 5 3
  • CGI-127 3

External Ids for YPEL5 Gene

Previous GeneCards Identifiers for YPEL5 Gene

  • GC02P030345
  • GC02P030281
  • GC02P030223
  • GC02P030369

Summaries for YPEL5 Gene

GeneCards Summary for YPEL5 Gene

YPEL5 (Yippee Like 5) is a Protein Coding gene. Among its related pathways are Innate Immune System. An important paralog of this gene is YPEL1.

Additional gene information for YPEL5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YPEL5 Gene

Genomics for YPEL5 Gene

GeneHancer (GH) Regulatory Elements for YPEL5 Gene

Promoters and enhancers for YPEL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J030145 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 658.2 +1.1 1062 5.7 HDGF PKNOX1 CLOCK ARID4B SIN3A ZNF2 ZBTB7B IRF4 YY1 SLC30A9 YPEL5 LOC101929418 ALK LBH PIR52638
GH02J030113 Enhancer 1 Ensembl ENCODE 17.1 -32.3 -32283 2.7 ELF3 RAD21 ZNF335 ZNF366 SCRT2 ZNF143 RCOR1 FOS ZNF654 REST YPEL5 LOC101929418 ENSG00000225943
GH02J030264 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +119.5 119508 4.4 CHAMP1 NR2F2 GABPA CC2D1A ZFHX2 JUND ZNF316 POLR2A NCOR1 EGR1 SNORA10B LBH YPEL5 GC02P030258 LOC102723594
GH02J030332 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.3 +189.4 189350 7.5 HDGF PKNOX1 RB1 STAT5A BATF KLF5 IRF4 ZBTB40 RAD21 ZNF207 SNORA10B YPEL5 LBH LINC01936 LOC102723594
GH02J030221 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6 +77.7 77664 6.3 BMI1 BATF ZNF366 ATF7 ETV6 IKZF2 RUNX3 CREM SMARCA5 CEBPB YPEL5 LBH ENSG00000231712
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around YPEL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the YPEL5 gene promoter:
  • MZF-1
  • STAT5A
  • FOXF2
  • ATF6
  • FOXO3b
  • FOXO3
  • FOXO3a
  • POU6F1 (c2)
  • POU2F1a

Genomic Locations for YPEL5 Gene

Genomic Locations for YPEL5 Gene
13,650 bases
Plus strand
13,650 bases
Plus strand

Genomic View for YPEL5 Gene

Genes around YPEL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YPEL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YPEL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YPEL5 Gene

Proteins for YPEL5 Gene

  • Protein details for YPEL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein yippee-like 5
    Protein Accession:
    Secondary Accessions:
    • D6W568
    • Q65Z97
    • Q8R174
    • Q9D6M1
    • Q9UMX7
    • Q9Y3C9

    Protein attributes for YPEL5 Gene

    121 amino acids
    Molecular mass:
    13842 Da
    Quaternary structure:
    No Data Available

neXtProt entry for YPEL5 Gene

Post-translational modifications for YPEL5 Gene

  • Ubiquitination at posLast=4747
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for YPEL5
  • Boster Bio Antibodies for YPEL5

No data available for DME Specific Peptides for YPEL5 Gene

Domains & Families for YPEL5 Gene

Gene Families for YPEL5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for YPEL5 Gene

Suggested Antigen Peptide Sequences for YPEL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the yippee family.
  • Belongs to the yippee family.
genes like me logo Genes that share domains with YPEL5: view

Function for YPEL5 Gene

Phenotypes From GWAS Catalog for YPEL5 Gene

Gene Ontology (GO) - Molecular Function for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with YPEL5: view
genes like me logo Genes that share phenotypes with YPEL5: view

Animal Model Products

miRNA for YPEL5 Gene

miRTarBase miRNAs that target YPEL5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YPEL5 Gene

Localization for YPEL5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YPEL5 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:1904724 tertiary granule lumen TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with YPEL5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for YPEL5 Gene

Pathways & Interactions for YPEL5 Gene

genes like me logo Genes that share pathways with YPEL5: view

Pathways by source for YPEL5 Gene

3 Reactome pathways for YPEL5 Gene

Gene Ontology (GO) - Biological Process for YPEL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with YPEL5: view

No data available for SIGNOR curated interactions for YPEL5 Gene

Drugs & Compounds for YPEL5 Gene

No Compound Related Data Available

Transcripts for YPEL5 Gene

Unigene Clusters for YPEL5 Gene

Yippee-like 5 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YPEL5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - -
SP10: -

Relevant External Links for YPEL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YPEL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YPEL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YPEL5 Gene

This gene is overexpressed in Hair follicle (36.6) and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for YPEL5 Gene

Protein tissue co-expression partners for YPEL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of YPEL5 Gene:


SOURCE GeneReport for Unigene cluster for YPEL5 Gene:


Evidence on tissue expression from TISSUES for YPEL5 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Lung(3.3)
  • Kidney(3)
  • Blood(2.4)
  • Bone marrow(2.3)
  • Spleen(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with YPEL5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YPEL5 Gene

Orthologs for YPEL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YPEL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia YPEL5 34
  • 100 (a)
(Pan troglodytes)
Mammalia YPEL5 34 33
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia YPEL5 34
  • 100 (a)
(Bos Taurus)
Mammalia YPEL5 34 33
  • 96.69 (n)
(Rattus norvegicus)
Mammalia Ypel5 33
  • 96.42 (n)
(Canis familiaris)
Mammalia YPEL5 34 33
  • 96.14 (n)
(Mus musculus)
Mammalia Ypel5 16 34 33
  • 95.87 (n)
(Gallus gallus)
Aves YPEL5 34 33
  • 86.5 (n)
(Anolis carolinensis)
Reptilia YPEL5 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ypel5 33
  • 81.82 (n)
Str.5006 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26158 33
(Danio rerio)
Actinopterygii ypel5 34
  • 93 (a)
LOC100332089 33
  • 79.89 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10271 33
fruit fly
(Drosophila melanogaster)
Insecta Yippee 34 33
  • 66.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000780 33
  • 64.62 (n)
(Caenorhabditis elegans)
Secernentea B0546.3 34
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOH1 34
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40110 33
  • 48.18 (n)
(Oryza sativa)
Liliopsida Os03g0698500 33
  • 50.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3746 34
  • 74 (a)
Cin.1753 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1753 33
Species where no ortholog for YPEL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YPEL5 Gene

Gene Tree for YPEL5 (if available)
Gene Tree for YPEL5 (if available)
Evolutionary constrained regions (ECRs) for YPEL5: view image

Paralogs for YPEL5 Gene

Paralogs for YPEL5 Gene

(4) SIMAP similar genes for YPEL5 Gene using alignment to 1 proteins:

  • YPEL5_HUMAN Pseudogenes for YPEL5 Gene

genes like me logo Genes that share paralogs with YPEL5: view

Variants for YPEL5 Gene

Sequence variations from dbSNP and Humsavar for YPEL5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000094465 -- 30,147,199(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000136868 -- 30,158,240(+) A/G intron_variant
rs1000474197 -- 30,154,044(+) A/G intron_variant
rs1000525914 -- 30,153,878(+) A/C intron_variant
rs1001031987 -- 30,160,712(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for YPEL5 Gene

Variant ID Type Subtype PubMed ID
nsv953763 CNV duplication 24416366
nsv581259 CNV gain+loss 21841781
esv34904 CNV gain 17911159
esv29927 CNV loss 19812545
esv2759035 CNV gain 17122850
dgv6747n54 CNV gain 21841781

Variation tolerance for YPEL5 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for YPEL5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YPEL5 Gene

Disorders for YPEL5 Gene

Additional Disease Information for YPEL5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for YPEL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YPEL5 Gene

Publications for YPEL5 Gene

  1. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. (PMID: 15556292) Hosono K … Shimizu N (Gene 2004) 2 3 4 22 58
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. (PMID: 11240639) Roxström-Lindquist K … Faye I (Insect molecular biology 2001) 3 4 58

Products for YPEL5 Gene

Sources for YPEL5 Gene

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