Aliases for RAP2B Gene
External Ids for RAP2B Gene
Previous GeneCards Identifiers for RAP2B Gene
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAP2B Gene
RAP2B (RAP2B, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP2B include Hypotrichosis 3 and Lung Squamous Cell Carcinoma. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAP2A.
UniProtKB/Swiss-Prot for RAP2B Gene
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.