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Aliases for HLA-B Gene

Aliases for HLA-B Gene

  • Major Histocompatibility Complex, Class I, B 2 3 3 5
  • HLAB 3 4
  • HLA Class I Histocompatibility Antigen, B-12 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-21 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-5 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B Alpha Chain 3
  • MHC Class I Antigen HLA-B Alpha Chain 3
  • MHC Class I Antigen HLA-B Heavy Chain 3
  • MHC HLA-B Transmembrane Glycoprotein 3
  • MHC HLA-B Cell Surface Glycoprotein 3
  • Leukocyte Antigen Class I-B 3
  • HLA Class I Antigen HLA-B 3
  • MHC Class I Antigen SHCHA 3
  • MHC Class I Antigen B*13 4
  • MHC Class I Antigen B*14 4
  • MHC Class I Antigen B*15 4
  • MHC Class I Antigen B*18 4
  • MHC Class I Antigen B*27 4
  • MHC Class I Antigen B*35 4
  • MHC Class I Antigen B*37 4
  • MHC Class I Antigen B*38 4
  • MHC Class I Antigen B*39 4
  • MHC Class I Antigen B*40 4
  • MHC Class I Antigen B*41 4
  • MHC Class I Antigen B*42 4
  • MHC Class I Antigen B*44 4
  • MHC Class I Antigen B*45 4
  • MHC Class I Antigen B*46 4
  • MHC Class I Antigen B*47 4
  • MHC Class I Antigen B*48 4
  • MHC Class I Antigen B*49 4
  • MHC Class I Antigen B*50 4
  • MHC Class I Antigen B*51 4
  • MHC Class I Antigen B*52 4
  • MHC Class I Antigen B*53 4
  • MHC Class I Antigen B*54 4
  • MHC Class I Antigen B*55 4
  • MHC Class I Antigen B*56 4
  • MHC Class I Antigen B*57 4
  • MHC Class I Antigen B*58 4
  • MHC Class I Antigen B*59 4
  • MHC Class I Antigen B*67 4
  • MHC Class I Antigen B*73 4
  • MHC Class I Antigen B*78 4
  • MHC Class I Antigen B*81 4
  • MHC Class I Antigen B*82 4
  • MHC Class I Antigen B*7 4
  • MHC Class I Antigen B*8 4
  • Ankylosing Spondylitis 2
  • MHC Class I Molecule 3
  • MHC Class 1 Antigen 3
  • B-4901 3
  • Bw-22 4
  • Bw-41 4
  • Bw-44 4
  • Bw-45 4
  • Bw-46 4
  • Bw-47 4
  • Bw-48 4
  • Bw-50 4
  • Bw-52 4
  • Bw-53 4
  • Bw-54 4
  • Bw-55 4
  • Bw-56 4
  • Bw-57 4
  • Bw-58 4
  • Bw-60 4
  • Bw-4 4
  • BDT 4
  • AS 3

External Ids for HLA-B Gene

Previous HGNC Symbols for HLA-B Gene

  • AS

Previous GeneCards Identifiers for HLA-B Gene

  • GC06M031376
  • GC06M031426
  • GC06M031342
  • GC06M031429
  • GC06M031345
  • GC06M031321
  • GC06M031112
  • GC06M031354

Summaries for HLA-B Gene

Entrez Gene Summary for HLA-B Gene

  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-B Gene

HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Severe Cutaneous Adverse Reaction and Spondyloarthropathy 1. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and peptide antigen binding. An important paralog of this gene is HLA-C.

Gene Wiki entry for HLA-B Gene

PharmGKB "VIP" Summary for HLA-B Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-B Gene

Genomics for HLA-B Gene

GeneHancer (GH) Regulatory Elements for HLA-B Gene

Promoters and enhancers for HLA-B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031352 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 677 +1.0 1020 7 HDGF PKNOX1 ATF1 SMAD1 ZNF2 IRF4 GLIS2 ZNF207 ZNF143 FOS HLA-B ENSG00000271581 GC06M031413 GC06M031414 MIR6891 PIR40863 HLA-C DDX39B MICA LY6G5B
GH06J031269 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +85.8 85751 4.4 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A GLI4 ZNF2 IRF4 YY1 HLA-C PIR41455 PSORS1C3 PPT2 TNXB LSM2 PSORS1C2 HCG18 HCG27 ENSG00000229836
GH06J031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 -380.2 -380243 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 MSH5-SAPCD1 DDX39B LY6G5B ATF6B LSM2 SKIV2L CSNK2B GPANK1
GH06J031619 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -264.0 -264015 4 CLOCK ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SNORA38 PRRC2A GC06P031991 GC06P031994 GC06P032031 GC06P032039 GC06P032042 GC06P032176 GC06P032224 GC06P032226
GH06J032175 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 -820.5 -820548 5.1 DMAP1 YBX1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 NR2C1 RNF5 AGPAT1 BRD2 DDX39B LY6G5B LSM2 ATF6B CSNK2B GPANK1 MICA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HLA-B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLA-B gene promoter:

Genomic Locations for HLA-B Gene

Genomic Locations for HLA-B Gene
chr6:31,269,491-31,357,212
(GRCh38/hg38)
Size:
87,722 bases
Orientation:
Minus strand
chr6:31,321,649-31,324,989
(GRCh37/hg19)

Genomic View for HLA-B Gene

Genes around HLA-B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-B Gene

  • Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30461-1B13_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, B-13 alpha chain
    Protein Accession:
    P30461
    Secondary Accessions:
    • O02956
    • O78180
    • Q29661
    • Q29933
    • Q9GIY5

    Protein attributes for HLA-B Gene

    Size:
    362 amino acids
    Molecular mass:
    40474 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

neXtProt entry for HLA-B Gene

Other Protein References for HLA-B Gene

No data available for DME Specific Peptides for HLA-B Gene

Domains & Families for HLA-B Gene

Gene Families for HLA-B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P01889

UniProtKB/Swiss-Prot:

1B27_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-B: view

Function for HLA-B Gene

Phenotypes From GWAS Catalog for HLA-B Gene

Gene Ontology (GO) - Molecular Function for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 18322206
GO:0042605 peptide antigen binding ISS,IBA --
genes like me logo Genes that share ontologies with HLA-B: view
genes like me logo Genes that share phenotypes with HLA-B: view

Human Phenotype Ontology for HLA-B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-B Gene

Localization for HLA-B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-B gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane IBA,TAS --
GO:0005887 integral component of plasma membrane NAS --
genes like me logo Genes that share ontologies with HLA-B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HLA-B Gene

Pathways & Interactions for HLA-B Gene

genes like me logo Genes that share pathways with HLA-B: view