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Aliases for HLA-A Gene

Aliases for HLA-A Gene

  • Major Histocompatibility Complex, Class I, A 2 3 5
  • HLA Class I Histocompatibility Antigen, A-1 Alpha Chain 3 4
  • HLAA 3 4
  • LOW QUALITY PROTEIN: HLA Class I Histocompatibility Antigen, A-1 Alpha Chain 3
  • HLA Class I Histocompatibility Antigen, A-10 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-28 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-9 Alpha Chain 4
  • MHC Class I Antigen HLA-A Heavy Chain 3
  • Leukocyte Antigen Class I-A 3
  • MHC Class I Antigen A*11 4
  • MHC Class I Antigen A*23 4
  • MHC Class I Antigen A*24 4
  • MHC Class I Antigen A*25 4
  • MHC Class I Antigen A*26 4
  • MHC Class I Antigen A*29 4
  • MHC Class I Antigen A*30 4
  • MHC Class I Antigen A*31 4
  • MHC Class I Antigen A*32 4
  • MHC Class I Antigen A*33 4
  • MHC Class I Antigen A*34 4
  • MHC Class I Antigen A*36 4
  • MHC Class I Antigen A*43 4
  • MHC Class I Antigen A*66 4
  • MHC Class I Antigen A*68 4
  • MHC Class I Antigen A*69 4
  • MHC Class I Antigen A*74 4
  • MHC Class I Antigen A*80 4
  • MHC Class I Antigen A*1 4
  • MHC Class I Antigen A*2 4
  • MHC Class I Antigen A*3 4
  • Aw-19 4
  • Aw-24 4
  • Aw-33 4
  • Aw-34 4
  • Aw-36 4
  • Aw-43 4
  • Aw-66 4
  • Aw-68 4
  • Aw-69 4
  • Aw-74 4
  • Aw-80 4

External Ids for HLA-A Gene

Previous GeneCards Identifiers for HLA-A Gene

  • GC06P029953
  • GC06P029626
  • GC06P029902
  • GC06P030016
  • GC06P030019
  • GC06P030020
  • GC06P029916
  • GC06P029918
  • GC06P029921
  • GC06P029933
  • GC06P029949
  • GC06P030186
  • GC06P030205
  • GC06P030244
  • GC06P030355
  • GC06P030504
  • GC06P030707
  • GC06P030868
  • GC06P031028
  • GC06P031179

Summaries for HLA-A Gene

Entrez Gene Summary for HLA-A Gene

  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-A Gene

HLA-A (Major Histocompatibility Complex, Class I, A) is a Protein Coding gene. Diseases associated with HLA-A include Severe Cutaneous Adverse Reaction and Birdshot Chorioretinopathy. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include peptide antigen binding. An important paralog of this gene is HLA-B.

Gene Wiki entry for HLA-A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-A Gene

Genomics for HLA-A Gene

GeneHancer (GH) Regulatory Elements for HLA-A Gene

Promoters and enhancers for HLA-A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029940 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 690.2 +1.0 1001 3.7 HDGF PKNOX1 SMAD1 ARID4B DMAP1 ZNF2 YY1 GLIS2 ZNF143 ATF7 HLA-A HCG4P5 PIR61557 HLA-J HLA-T HLA-G HLA-H HLA-W HLA-K ZNRD1
GH06J029963 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 40.6 +25.0 24989 4.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 HLA-A HLA-K HCG4P3 ZNRD1 HLA-W TRIM39 HLA-H PPP1R10 MDC1 DHX16
GH06J030065 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.5 +125.5 125545 3 ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC PPP1R11 TRIM39 ZNRD1 HCG4P3 TRIM26 PPP1R10 NRM MDC1 HLA-A RPL7P4
GH06J030060 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.5 +120.5 120453 3.3 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNRD1 ENSG00000278773 GC06M030371 GC06M030373 GC06M030375 GC06M030380 GC06M030381 GC06M030383 GC06M030385 GC06M030386
GH06J029924 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 32.6 -15.2 -15187 3.6 MLX ARID4B DMAP1 RFX5 YY1 KLF11 RXRA SMAD5 CEBPB ZHX2 HLA-K GC06M030389 HCG4B HLA-A MICD ZFP57 HLA-J HLA-H HCG4P3 RPL23AP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HLA-A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLA-A gene promoter:
  • AP-1
  • NF-kappaB1
  • c-Jun
  • ATF-2
  • MyoD
  • AML1a

Genomic Locations for HLA-A Gene

Genomic Locations for HLA-A Gene
chr6:29,941,260-29,945,884
(GRCh38/hg38)
Size:
4,625 bases
Orientation:
Plus strand
chr6:29,909,037-29,913,661
(GRCh37/hg19)
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for HLA-A Gene

Genes around HLA-A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-A Gene

  • Protein details for HLA-A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01892-1A02_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, A-2 alpha chain
    Protein Accession:
    P01892
    Secondary Accessions:
    • O19619
    • P06338
    • P10313
    • P30444
    • P30445
    • P30446
    • P30514
    • Q29680
    • Q29837
    • Q29899
    • Q95352
    • Q95380
    • Q9TPX8
    • Q9TPX9
    • Q9TPY0
    • Q9TQH5
    • Q9TQI3

    Protein attributes for HLA-A Gene

    Size:
    365 amino acids
    Molecular mass:
    40922 Da
    Quaternary structure:
    • Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Interacts with HTLV-1 accessory protein p12I.
    SequenceCaution:
    • Sequence=CAA41022.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown extensively.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-A Gene

neXtProt entry for HLA-A Gene

Post-translational modifications for HLA-A Gene

Antibody Products

No data available for DME Specific Peptides for HLA-A Gene

Domains & Families for HLA-A Gene

Gene Families for HLA-A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P30443

UniProtKB/Swiss-Prot:

1A23_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-A: view

Function for HLA-A Gene

Molecular function for HLA-A Gene

UniProtKB/Swiss-Prot Function:
Involved in the presentation of foreign antigens to the immune system.
GENATLAS Biochemistry:
HLA-A,alpha chain,44kDa,class Ia ,ubiquitously expressed,except central nervous system,placenta,sperm cells (see MHC1)

Phenotypes From GWAS Catalog for HLA-A Gene

Gene Ontology (GO) - Molecular Function for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 23401559
GO:0030881 beta-2-microglobulin binding ISS --
GO:0042605 peptide antigen binding IDA,ISS --
genes like me logo Genes that share ontologies with HLA-A: view
genes like me logo Genes that share phenotypes with HLA-A: view

Human Phenotype Ontology for HLA-A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

  • Addgene plasmids for HLA-A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-A Gene

Localization for HLA-A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with HLA-A: view

Pathways & Interactions for HLA-A Gene

genes like me logo Genes that share pathways with HLA-A: view