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Aliases for ATF6 Gene

Aliases for ATF6 Gene

  • Activating Transcription Factor 6 2 3 5
  • CAMP-Dependent Transcription Factor ATF-6 Alpha 3 4
  • Activating Transcription Factor 6 Alpha 2 4
  • Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha 3
  • ATF6-Alpha 4
  • ACHM7 3
  • ATF6A 3

External Ids for ATF6 Gene

Previous GeneCards Identifiers for ATF6 Gene

  • GC01P159370
  • GC01P157386
  • GC01P158432
  • GC01P158923
  • GC01P158467
  • GC01P160002
  • GC01P161736
  • GC01P132981

Summaries for ATF6 Gene

Entrez Gene Summary for ATF6 Gene

  • This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

GeneCards Summary for ATF6 Gene

ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 and Achromatopsia. Among its related pathways are ERK Signaling and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is ATF6B.

UniProtKB/Swiss-Prot for ATF6 Gene

  • Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5-CCAC[GA]-3half of the ER stress response element (ERSE) (5-CCAAT-N(9)-CCAC[GA]-3) and of ERSE II (5-ATTGG-N-CCACG-3). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Gene Wiki entry for ATF6 Gene

Additional gene information for ATF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF6 Gene

Genomics for ATF6 Gene

GeneHancer (GH) Regulatory Elements for ATF6 Gene

Promoters and enhancers for ATF6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J161764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 668.3 -0.2 -167 2.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF610 ATF6 LOC102724329 USP21 DEDD B4GALT3 DUSP12 PPOX UAP1 TSTD1 FCRLB
GH01J161130 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.9 -633.9 -633863 3.9 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 DEDD UFC1 USP21 DUSP12 ENSG00000228606 B4GALT3 PPOX NCSTN ATF6 DCAF8
GH01J161398 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 38.7 -366.8 -366806 3.2 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC PIR55576 TRV-CAC1-1 RNU6-481P ENSG00000283696 USP21 DEDD PPOX B4GALT3 ATF6 DUSP12
GH01J161096 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.8 -668.6 -668566 2.9 YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MCM3 KLHDC9 USP21 DUSP12 PPOX ENSG00000228606 DEDD NCSTN RPSAP18 LOC148430 DCAF8
GH01J161611 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.3 -153.9 -153943 2.6 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 GC01P161612 TRL-CAA6-1 GC01P161613 USP21 DEDD FCGR2B DUSP12 B4GALT3 ATF6 FCGR2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ATF6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ATF6 gene promoter:
  • CREB
  • deltaCREB
  • ATF6
  • USF-1
  • USF1
  • AML1a
  • c-Myb
  • Tal-1
  • E47

Genomic Locations for ATF6 Gene

Genomic Locations for ATF6 Gene
chr1:161,766,244-161,964,070
(GRCh38/hg38)
Size:
197,827 bases
Orientation:
Plus strand
chr1:161,736,084-161,933,860
(GRCh37/hg19)
Size:
197,777 bases
Orientation:
Plus strand

Genomic View for ATF6 Gene

Genes around ATF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF6 Gene

Proteins for ATF6 Gene

  • Protein details for ATF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18850-ATF6A_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-6 alpha
    Protein Accession:
    P18850
    Secondary Accessions:
    • O15139
    • Q5VW62
    • Q6IPB5
    • Q9UEC9

    Protein attributes for ATF6 Gene

    Size:
    670 amino acids
    Molecular mass:
    74585 Da
    Quaternary structure:
    • Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF. Interacts (via lumenal domain) with THBS1 (By similarity). Interacts with THBS4 (via EGF-like 3; calcium-binding domain) which facilitates its processing, activation and nuclear translocation (PubMed:22682248). Interacts with XBP1 isoform 2; the interaction occurs in a ER stress-dependent manner (PubMed:17765680).

neXtProt entry for ATF6 Gene

Post-translational modifications for ATF6 Gene

  • During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.
  • N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR).
  • Phosphorylated in vitro by MAPK14/P38MAPK.
  • Glycosylation at posLast=643643, posLast=584584, and posLast=472472
  • Ubiquitination at Lys436 and Lys424
  • Modification sites at PhosphoSitePlus

Other Protein References for ATF6 Gene

No data available for DME Specific Peptides for ATF6 Gene

Domains & Families for ATF6 Gene

Gene Families for ATF6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ATF6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18850

UniProtKB/Swiss-Prot:

ATF6A_HUMAN :
  • The basic domain functions as a nuclear localization signal.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • The basic domain functions as a nuclear localization signal.
  • The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF6: view

Function for ATF6 Gene

Molecular function for ATF6 Gene

UniProtKB/Swiss-Prot Function:
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5-CCAC[GA]-3half of the ER stress response element (ERSE) (5-CCAAT-N(9)-CCAC[GA]-3) and of ERSE II (5-ATTGG-N-CCACG-3). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Phenotypes From GWAS Catalog for ATF6 Gene

Gene Ontology (GO) - Molecular Function for ATF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 16469704
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11779464
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 24269637
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC --
genes like me logo Genes that share ontologies with ATF6: view
genes like me logo Genes that share phenotypes with ATF6: view

Human Phenotype Ontology for ATF6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ATF6 Gene

MGI Knock Outs for ATF6:
  • Atf6 Atf6<tm1.1Rjk>
  • Atf6 Atf6<tm1Kamo>

Animal Model Products

Transcription Factor Targets for ATF6 Gene

Selected GeneGlobe predicted Target genes for ATF6

Clone Products

  • Addgene plasmids for ATF6

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for ATF6 Gene

Localization for ATF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF6 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF6 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
mitochondrion 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus TAS,IDA 11163209
GO:0005635 nuclear envelope TAS 10866666
GO:0005654 nucleoplasm TAS --
GO:0005783 endoplasmic reticulum IDA 11256944
genes like me logo Genes that share ontologies with ATF6: view

Pathways & Interactions for ATF6 Gene

genes like me logo Genes that share pathways with ATF6: view

SIGNOR curated interactions for ATF6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ATF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development IMP 26029869
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 10564271
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ATF6: view

Drugs & Compounds for ATF6 Gene

(7) Drugs for ATF6 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target, inhibitor 666

(2) Additional Compounds for ATF6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF6: view

Transcripts for ATF6 Gene

mRNA/cDNA for ATF6 Gene

Unigene Clusters for ATF6 Gene

Activating transcription factor 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for ATF6

Alternative Splicing Database (ASD) splice patterns (SP) for ATF6 Gene

No ASD Table

Relevant External Links for ATF6 Gene

GeneLoc Exon Structure for
ATF6
ECgene alternative splicing isoforms for
ATF6

Expression for ATF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATF6 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for ATF6 Gene

This gene is overexpressed in Serum (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF6 Gene



Protein tissue co-expression partners for ATF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATF6 Gene:

ATF6

SOURCE GeneReport for Unigene cluster for ATF6 Gene:

Hs.492740

mRNA Expression by UniProt/SwissProt for ATF6 Gene:

P18850-ATF6A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ATF6 Gene

  • Pancreas(4.5)
  • Nervous system(4.2)
  • Liver(3)
  • Kidney(2.9)
  • Heart(2.7)
  • Lung(2.7)
  • Muscle(2.4)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF6 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • eyelid
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with ATF6: view

Orthologs for ATF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF6 34 33
  • 99.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATF6 34 33
  • 91.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATF6 34 33
  • 89.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Atf6 16 34 33
  • 84.91 (n)
rat
(Rattus norvegicus)
Mammalia Atf6 33
  • 84.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ATF6 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATF6 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATF6 34 33
  • 68.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATF6 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf6 33
  • 62.06 (n)
zebrafish
(Danio rerio)
Actinopterygii atf6 34 33
  • 54.69 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atf6 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for ATF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF6 Gene

ENSEMBL:
Gene Tree for ATF6 (if available)
TreeFam:
Gene Tree for ATF6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ATF6: view image

Paralogs for ATF6 Gene

Paralogs for ATF6 Gene

(1) SIMAP similar genes for ATF6 Gene using alignment to 1 proteins:

  • ATF6A_HUMAN
genes like me logo Genes that share paralogs with ATF6: view

Variants for ATF6 Gene

Sequence variations from dbSNP and Humsavar for ATF6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs749537392 likely-pathogenic, Macular dystrophy 161,819,741(+) G/A/C coding_sequence_variant, missense_variant
rs761129859 pathogenic, Achromatopsia 7 161,821,166(+) G/A/C intron_variant
rs761357250 pathogenic, Achromatopsia 7, Achromatopsia 7 (ACHM7) [MIM:616517] 161,819,693(+) C/T coding_sequence_variant, missense_variant
rs765383904 likely-pathogenic, Achromatopsia 161,791,470(+) T/TT coding_sequence_variant, stop_gained
rs796065053 pathogenic, Achromatopsia 7, Achromatopsia 7 (ACHM7) [MIM:616517] 161,863,292(+) T/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ATF6 Gene

Variant ID Type Subtype PubMed ID
esv3304870 CNV mobile element insertion 20981092
esv3336606 CNV duplication 20981092
esv33393 CNV gain+loss 17666407
esv3450329 CNV insertion 20981092
esv3578231 CNV loss 25503493
esv3587736 CNV gain 21293372
esv3587737 CNV loss 21293372
nsv1007108 CNV gain 25217958
nsv1014340 CNV loss 25217958
nsv1137819 CNV deletion 24896259
nsv3276 CNV insertion 18451855
nsv428257 CNV loss 18775914
nsv464184 CNV gain 19166990
nsv464206 CNV gain 19166990
nsv470744 CNV gain 18288195
nsv548075 CNV gain 21841781
nsv548077 CNV gain 21841781
nsv831747 CNV loss 17160897

Variation tolerance for ATF6 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.62; 93.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ATF6 Gene

Human Gene Mutation Database (HGMD)
ATF6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF6 Gene

Disorders for ATF6 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ATF6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
achromatopsia 7
  • achm7
achromatopsia
  • achm
retinitis pigmentosa
  • retinitis pigmentosa 1
wolfram syndrome 1
  • wfs1
wolfram syndrome
  • wfs
- elite association - COSMIC cancer census association via MalaCards
Search ATF6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ATF6A_HUMAN
  • Achromatopsia 7 (ACHM7) [MIM:616517]: A form of achromatopsia, an ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. {ECO:0000269 PubMed:26029869, ECO:0000269 PubMed:26063662}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ATF6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ATF6: view

No data available for Genatlas for ATF6 Gene

Publications for ATF6 Gene

  1. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. (PMID: 9837962) Yoshida H … Mori K (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Interaction of ATF6 and serum response factor. (PMID: 9271374) Zhu C … Prywes R (Molecular and cellular biology 1997) 2 3 4 22 58
  3. The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. (PMID: 19667116) Meex SJ … Glembotski CC (Arteriosclerosis, thrombosis, and vascular biology 2009) 3 22 44 58
  4. Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. (PMID: 17440018) Meex SJ … de Bruin TW (The Journal of clinical endocrinology and metabolism 2007) 3 22 44 58
  5. Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. (PMID: 17327457) Chu WS … Elbein SC (Diabetes 2007) 3 22 44 58

Products for ATF6 Gene

  • Addgene plasmids for ATF6

Sources for ATF6 Gene