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Aliases for GGT3P Gene

Aliases for GGT3P Gene

  • Gamma-Glutamyltransferase 3 Pseudogene 2 3 5
  • Gamma-Glutamyltransferase 3 2 4
  • GGT3 3 4
  • Putative Gamma-Glutamyltranspeptidase 3 4
  • EC 3.4.19.13 4
  • EC 2.3.2.2 4
  • GGT 3 4

External Ids for GGT3P Gene

Previous HGNC Symbols for GGT3P Gene

  • GGT3

Previous GeneCards Identifiers for GGT3P Gene

  • GC22M017143
  • GC22M018765

Summaries for GGT3P Gene

GeneCards Summary for GGT3P Gene

GGT3P (Gamma-Glutamyltransferase 3 Pseudogene) is a Pseudogene. Diseases associated with GGT3P include Intrahepatic Cholestasis. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity and glutathione hydrolase activity.

UniProtKB/Swiss-Prot for GGT3P Gene

  • Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.

Additional gene information for GGT3P Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GGT3P Gene

Genomics for GGT3P Gene

GeneHancer (GH) Regulatory Elements for GGT3P Gene

Promoters and enhancers for GGT3P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J018833 Promoter 0.5 Ensembl 0.4 +9.9 9898 0.2 E2F6P1 GGT3P PIRC107
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GGT3P on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GGT3P gene promoter:
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • Arnt
  • AhR
  • IRF-2
  • GATA-2
  • CBF(2)
  • CBF-A

Genomic Locations for GGT3P Gene

Genomic Locations for GGT3P Gene
chr22:18,773,665-18,843,399
(GRCh38/hg38)
Size:
69,735 bases
Orientation:
Minus strand
chr22:18,761,178-18,830,912
(GRCh37/hg19)
Size:
69,735 bases
Orientation:
Minus strand

Genomic View for GGT3P Gene

Genes around GGT3P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGT3P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGT3P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGT3P Gene

Proteins for GGT3P Gene

  • Protein details for GGT3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGU5-GGT3_HUMAN
    Recommended name:
    Putative glutathione hydrolase 3 proenzyme
    Protein Accession:
    A6NGU5

    Protein attributes for GGT3P Gene

    Size:
    568 amino acids
    Molecular mass:
    61502 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In some epileptic patients treated with phenytoin, phenobarbital and carbamazepin, GGT3 is found, as an additional form of GGT. This group of patients has levels of ceruloplasmin and oxidase activity that were significantly higher than in the group of patients without GGT3. However, levels of ceruloplasmin and oxidase activity are significantly higher in this group of patients without GGT3 than those of the control group.

neXtProt entry for GGT3P Gene

Post-translational modifications for GGT3P Gene

  • Cleaved by autocatalysis into a large and a small subunit.
  • Glycosylation at Asn510, isoforms=344, Asn297, isoforms=266, Asn230, Asn120, and isoforms=95

No data available for DME Specific Peptides for GGT3P Gene

Domains & Families for GGT3P Gene

Gene Families for GGT3P Gene

Protein Domains for GGT3P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGT3P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGU5

UniProtKB/Swiss-Prot:

GGT3_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGT3P: view

Function for GGT3P Gene

Molecular function for GGT3P Gene

UniProtKB/Swiss-Prot Function:
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.
UniProtKB/Swiss-Prot CatalyticActivity:
A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione + H(2)O = L-cysteinylglycine + L-glutamate.

Enzyme Numbers (IUBMB) for GGT3P Gene

Gene Ontology (GO) - Molecular Function for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0036374 glutathione hydrolase activity IEA --
GO:0102953 hypoglycin A gamma-glutamyl transpeptidase activity IEA --
GO:0103068 leukotriene C4 gamma-glutamyl transferase activity IEA --
genes like me logo Genes that share ontologies with GGT3P: view
genes like me logo Genes that share phenotypes with GGT3P: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGT3P Gene

Localization for GGT3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGT3P Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GGT3P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GGT3P Gene

Pathways & Interactions for GGT3P Gene

genes like me logo Genes that share pathways with GGT3P: view

UniProtKB/Swiss-Prot A6NGU5-GGT3_HUMAN

  • Pathway: Sulfur metabolism; glutathione metabolism.

Interacting Proteins for GGT3P Gene

Selected Interacting proteins: A6NGU5-GGT3_HUMAN for GGT3P Gene via IID

Gene Ontology (GO) - Biological Process for GGT3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006750 glutathione biosynthetic process IEA --
GO:0006751 glutathione catabolic process IEA --
GO:0008150 biological_process ND --
GO:1901750 leukotriene D4 biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGT3P: view

No data available for SIGNOR curated interactions for GGT3P Gene

Drugs & Compounds for GGT3P Gene

(3) Drugs for GGT3P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Glutamic Acid Approved Nutra Full agonist, Agonist 251
Glutathione Approved, Investigational Nutra 0

(1) Additional Compounds for GGT3P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cysteinylglycine
  • CG
  • Cys-gly
  • N-L-Cysteinylglycine
  • L-Cysteinylglycine
  • N-Cysteinyl glycine
19246-18-5
genes like me logo Genes that share compounds with GGT3P: view

Transcripts for GGT3P Gene

mRNA/cDNA for GGT3P Gene

(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GGT3P Gene

Gamma-glutamyltransferase 3 pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGT3P Gene

No ASD Table

Relevant External Links for GGT3P Gene

GeneLoc Exon Structure for
GGT3P
ECgene alternative splicing isoforms for
GGT3P

Expression for GGT3P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GGT3P Gene

mRNA differential expression in normal tissues according to GTEx for GGT3P Gene

This gene is overexpressed in Kidney - Cortex (x24.3) and Thyroid (x15.9).

NURSA nuclear receptor signaling pathways regulating expression of GGT3P Gene:

GGT3P

SOURCE GeneReport for Unigene cluster for GGT3P Gene:

Hs.595809
genes like me logo Genes that share expression patterns with GGT3P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGT3P Gene

Orthologs for GGT3P Gene

Evolution for GGT3P Gene

ENSEMBL:
Gene Tree for GGT3P (if available)
TreeFam:
Gene Tree for GGT3P (if available)

No data available for Orthologs for GGT3P Gene

Paralogs for GGT3P Gene

(8) SIMAP similar genes for GGT3P Gene using alignment to 1 proteins:

  • GGT3_HUMAN
genes like me logo Genes that share paralogs with GGT3P: view

No data available for Paralogs for GGT3P Gene

Variants for GGT3P Gene

Sequence variations from dbSNP and Humsavar for GGT3P Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000175684 -- 18,776,403(-) T/C intron_variant
rs1000227865 -- 18,775,174(-) G/A non_coding_transcript_variant
rs1001134131 -- 18,783,715(-) G/T intron_variant
rs1001227425 -- 18,781,859(-) GG/G intron_variant
rs1005483885 -- 18,780,480(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GGT3P Gene

Variant ID Type Subtype PubMed ID
dgv1283e212 CNV gain 25503493
dgv169n111 CNV duplication 26073780
dgv173e55 CNV gain 17911159
dgv19e196 CNV duplication 17116639
dgv2565e59 CNV duplication 20981092
dgv2566e59 CNV duplication 20981092
dgv4466n100 CNV gain+loss 25217958
dgv4467n100 CNV gain 25217958
dgv4468n100 CNV gain+loss 25217958
dgv4469n100 CNV gain 25217958
dgv7963n54 CNV gain 21841781
dgv99e203 CNV gain+loss 21179565
esv22247 CNV gain+loss 19812545
esv2422290 CNV deletion 17116639
esv2751935 CNV loss 17911159
esv2758824 CNV gain+loss 17122850
esv32687 CNV gain+loss 17666407
esv3328287 CNV duplication 20981092
esv3369734 CNV duplication 20981092
esv3369963 CNV duplication 20981092
esv3385979 CNV duplication 20981092
esv3422899 CNV duplication 20981092
esv3432226 CNV duplication 20981092
esv3432286 CNV duplication 20981092
esv3575418 CNV gain 25503493
esv3584483 CNV gain 24956385
esv3893432 CNV gain 25118596
nsv1055756 CNV gain 25217958
nsv1061694 CNV gain 25217958
nsv1077932 CNV duplication 25765185
nsv1078507 CNV duplication 25765185
nsv1118686 CNV duplication 24896259
nsv1128852 CNV duplication 24896259
nsv1141410 CNV duplication 24896259
nsv1151039 CNV duplication 26484159
nsv428385 CNV gain+loss 18775914
nsv469578 CNV gain 16826518
nsv469851 CNV gain 16826518
nsv471339 CNV gain 19718026
nsv471594 CNV gain+loss 15918152
nsv516997 CNV gain+loss 19592680
nsv821058 CNV duplication 20802225
nsv953018 CNV duplication 24416366
nsv953688 CNV deletion 24416366
nsv966136 CNV duplication 23825009
nsv979631 CNV duplication 23825009

Additional Variant Information for GGT3P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGT3P

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GGT3P Gene

Disorders for GGT3P Gene

MalaCards: The human disease database

(1) MalaCards diseases for GGT3P Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
- elite association - COSMIC cancer census association via MalaCards
Search GGT3P in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GGT3P

genes like me logo Genes that share disorders with GGT3P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGT3P Gene

Publications for GGT3P Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N … Sneddon TP (Human genetics 2008) 2 3 4 58
  2. Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes. (PMID: 8104871) Figlewicz DA … Rouleau GA (Genomics 1993) 2 3 58
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  4. Characterization of ATP8B1 gene mutations and a hot-linked mutation found in Chinese children with progressive intrahepatic cholestasis and low GGT. (PMID: 20038848) Liu LY … Wang JS (Journal of pediatric gastroenterology and nutrition 2010) 22 58
  5. Refining the 22q11.2 deletion breakpoints in DiGeorge syndrome by aCGH. (PMID: 19420922) Bittel DC … Cooley LD (Cytogenetic and genome research 2009) 22 58

Products for GGT3P Gene

Sources for GGT3P Gene

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