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Aliases for PGC Gene

Aliases for PGC Gene

  • Progastricsin 2 3 5
  • Pepsinogen C 2 3 4
  • Progastricsin (Pepsinogen C) 2
  • Pepsinogen Group II 3
  • Preprogastricsin 3
  • EC 4
  • Gastricsin 3
  • Pepsin C 3
  • PEPC 3
  • PGII 3

External Ids for PGC Gene

Previous GeneCards Identifiers for PGC Gene

  • GC06M041706
  • GC06M041751
  • GC06M041813
  • GC06M041704
  • GC06M041423

Summaries for PGC Gene

Entrez Gene Summary for PGC Gene

  • This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

GeneCards Summary for PGC Gene

PGC (Progastricsin) is a Protein Coding gene. Diseases associated with PGC include Gastritis and Atrophic Gastritis. Gene Ontology (GO) annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is PGA3.

UniProtKB/Swiss-Prot for PGC Gene

  • Hydrolyzes a variety of proteins.

Gene Wiki entry for PGC Gene

Additional gene information for PGC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGC Gene

Genomics for PGC Gene

GeneHancer (GH) Regulatory Elements for PGC Gene

Promoters and enhancers for PGC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J041746 Promoter/Enhancer 1.5 EPDnew ENCODE 650.4 +6.5 6506 2.9 FOXA2 ARID4B DMAP1 ETS1 SLC30A9 TCF12 ZNF766 GATA2 ATF7 NFKBIZ PGC TFEB
GH06J041718 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +26.6 26597 17.6 MLX DMAP1 YBX1 IRF4 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 TFEB PGC ENSG00000124593 ENSG00000231102
GH06J041704 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +47.6 47643 4.9 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF48 ARID2 ZNF207 GC06M041707 GC06M041708 TFEB TAF8 PGC MED20 UBR2 MDFI TREML3P ENSG00000124593
GH06J041711 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.7 +40.6 40630 3.8 HDGF ZSCAN4 KLF17 STAT5A BATF IRF4 YY1 ATF7 FOS ETV6 GC06P043169 TFEB PGC MDFI GC06M041707 GC06M041708
GH06J041715 Enhancer 1 Ensembl ENCODE dbSUPER 12.8 +37.1 37127 2.3 ZNF687 ZNF792 EBF1 ZIC2 ZFHX2 ZKSCAN8 GLIS1 FOS SPI1 PGC MDFI ENSG00000124593 GC06P043169 ENSG00000231102 TFEB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PGC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PGC gene promoter:
  • p53
  • FOXD1
  • C/EBPbeta
  • Brachyury
  • MZF-1
  • p300
  • CP2
  • Meis-1b
  • Meis-1
  • HOXA9B

Genomic Locations for PGC Gene

Genomic Locations for PGC Gene
17,399 bases
Minus strand
17,399 bases
Minus strand

Genomic View for PGC Gene

Genes around PGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGC Gene

Proteins for PGC Gene

  • Protein details for PGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DVZ3
    • Q5T3D7
    • Q5T3D8

    Protein attributes for PGC Gene

    388 amino acids
    Molecular mass:
    42426 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA60062.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PGC Gene

    Alternative splice isoforms for PGC Gene


neXtProt entry for PGC Gene

Post-translational modifications for PGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGC Gene

No data available for DME Specific Peptides for PGC Gene

Domains & Families for PGC Gene

Gene Families for PGC Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PGC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase A1 family.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with PGC: view

Function for PGC Gene

Molecular function for PGC Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes a variety of proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr- -Xaa bonds. High activity on hemoglobin.
GENATLAS Biochemistry:
progastricsin (pepsinogen C)

Enzyme Numbers (IUBMB) for PGC Gene

Phenotypes From GWAS Catalog for PGC Gene

Gene Ontology (GO) - Molecular Function for PGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity TAS,IMP 12759353
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PGC: view
genes like me logo Genes that share phenotypes with PGC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PGC

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PGC Gene

Localization for PGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGC Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGC gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
mitochondrion 2
cytosol 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS,IDA 12759353
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with PGC: view

Pathways & Interactions for PGC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002803 positive regulation of antibacterial peptide production IMP 12759353
GO:0006508 proteolysis TAS,IEA --
GO:0006914 autophagy IBA --
GO:0007586 digestion IEA --
GO:0030163 protein catabolic process IBA --
genes like me logo Genes that share ontologies with PGC: view

No data available for Pathways by source and SIGNOR curated interactions for PGC Gene

Drugs & Compounds for PGC Gene

(1) Drugs for PGC Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ecabet Approved, Investigational Pharma 5

(1) Additional Compounds for PGC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PGC: view

Transcripts for PGC Gene

mRNA/cDNA for PGC Gene

Unigene Clusters for PGC Gene

Progastricsin (pepsinogen C):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: - -

Relevant External Links for PGC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGC Gene

This gene is overexpressed in Stomach (x51.9).

Protein differential expression in normal tissues from HIPED for PGC Gene

This gene is overexpressed in Stomach (49.9) and Cardia (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PGC Gene

NURSA nuclear receptor signaling pathways regulating expression of PGC Gene:


SOURCE GeneReport for Unigene cluster for PGC Gene:


Evidence on tissue expression from TISSUES for PGC Gene

  • Stomach(5)
  • Liver(4.2)
  • Lung(2.5)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PGC: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGC Gene

Orthologs for PGC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGC 34 33
  • 99.57 (n)
(Bos Taurus)
Mammalia PGC 34 33
  • 86.56 (n)
(Monodelphis domestica)
Mammalia PGC 34
  • 80 (a)
(Rattus norvegicus)
Mammalia Pgc 33
  • 79.98 (n)
(Mus musculus)
Mammalia Pgc 16 34 33
  • 78.87 (n)
(Canis familiaris)
Mammalia PGC 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia PGC 34
  • 44 (a)
(Gallus gallus)
Aves PGC 34 33
  • 71.25 (n)
(Anolis carolinensis)
Reptilia PGC 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496913 33
  • 66.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia pgc-A 33
fruit fly
(Drosophila melanogaster)
Insecta CG17134 35
  • 43 (a)
CG13095 35
  • 43 (a)
CG6508 35
  • 42 (a)
pcl 35
  • 41 (a)
CG10104 35
  • 39 (a)
CG5860 35
  • 37 (a)
CG17283 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea asp-2 35
  • 34 (a)
Y39B6A.23 35
  • 34 (a)
C11D2.2 35
  • 34 (a)
asp-6 35
  • 33 (a)
F21F8.4 35
  • 33 (a)
Y39B6A.24 35
  • 32 (a)
asp-5 35
  • 32 (a)
Y39B6A.21 35
  • 32 (a)
F59D6.2 35
  • 31 (a)
C15C8.3 35
  • 31 (a)
Y39B6A.22 35
  • 31 (a)
F28A12.4 35
  • 31 (a)
F59D6.3 35
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR144W 33
  • 50.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPS3 36
Species where no ortholog for PGC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PGC Gene

Gene Tree for PGC (if available)
Gene Tree for PGC (if available)
Evolutionary constrained regions (ECRs) for PGC: view image

Paralogs for PGC Gene

Paralogs for PGC Gene

(7) SIMAP similar genes for PGC Gene using alignment to 3 proteins:

  • A2A3L9_HUMAN
  • Q4VXA6_HUMAN Pseudogenes for PGC Gene

genes like me logo Genes that share paralogs with PGC: view

Variants for PGC Gene

Sequence variations from dbSNP and Humsavar for PGC Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000033663 -- 41,747,796(-) T/A/G upstream_transcript_variant
rs1000188570 -- 41,746,252(-) G/A intron_variant
rs1000408957 -- 41,746,533(-) G/A intron_variant
rs1000831353 -- 41,740,290(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000985009 -- 41,747,612(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PGC Gene

Variant ID Type Subtype PubMed ID
dgv10637n54 CNV gain 21841781
esv2211967 CNV deletion 18987734
esv2731977 CNV deletion 23290073
esv2731978 CNV deletion 23290073
nsv602988 CNV loss 21841781

Variation tolerance for PGC Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PGC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGC Gene

Disorders for PGC Gene

MalaCards: The human disease database

(4) MalaCards diseases for PGC Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute gastric mucosal erosion
atrophic gastritis
  • gastric atrophy
  • dyspepsia, indigestion
stomach disease
  • gastric disease
- elite association - COSMIC cancer census association via MalaCards
Search PGC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PGC

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PGC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGC Gene

Publications for PGC Gene

  1. Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin. (PMID: 9406551) Khan AR … James MN (Nature structural biology 1997) 3 4 22 58
  2. Crystal and molecular structures of human progastricsin at 1.62 A resolution. (PMID: 7714902) Moore SA … James MN (Journal of molecular biology 1995) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. [Correlation of pepsinogen C (PGC) gene insertion/deletion polymorphism to PGC protein expression in gastric mucosa and serum]. (PMID: 19624876) Sun LP … Yuan Y (Ai zheng = Aizheng = Chinese journal of cancer 2009) 3 44 58
  5. Impact of pepsinogen C polymorphism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population. (PMID: 19132389) Sun LP … Yuan Y (Journal of cancer research and clinical oncology 2009) 3 44 58

Products for PGC Gene

Sources for PGC Gene

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