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Aliases for HPX Gene

Aliases for HPX Gene

  • Hemopexin 2 3 3 5
  • Beta-1B-Glycoprotein 3 4
  • HX 3

External Ids for HPX Gene

Previous GeneCards Identifiers for HPX Gene

  • GC11M007195
  • GC11M006912
  • GC11M006411
  • GC11M006416
  • GC11M006408
  • GC11M006112

Summaries for HPX Gene

Entrez Gene Summary for HPX Gene

  • This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

GeneCards Summary for HPX Gene

HPX (Hemopexin) is a Protein Coding gene. Diseases associated with HPX include Blackwater Fever and Testicular Yolk Sac Tumor. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include heme transporter activity.

UniProtKB/Swiss-Prot for HPX Gene

  • Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Gene Wiki entry for HPX Gene

Additional gene information for HPX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPX Gene

Genomics for HPX Gene

GeneHancer (GH) Regulatory Elements for HPX Gene

Promoters and enhancers for HPX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006440 Promoter 1.2 EPDnew 650.7 +1.6 1610 0.1 FOXA2 ARID4B ZSCAN9 RAD21 RARA YY1 EGR1 CREM THAP11 MIXL1 HPX APBB1
GH11J006443 Enhancer 0.7 ENCODE 650.7 -1.0 -979 0.2 CTCF TAF1 ZFP64 MAX RAD21 YY1 MTA3 HNF4G ZNF143 SMC3 HPX APBB1 ARFIP2 TIMM10B SMPD1 GC11P006457
GH11J006400 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 +39.2 39247 5.5 SIN3A BATF IRF4 SCRT2 ETV6 BCLAF1 IKZF2 RUNX3 CREM CBFB SMPD1 HPX ARFIP2 TIMM10B CAVIN3 APBB1 GC11P006400 PIR40798
GH11J006439 Enhancer 0.7 ENCODE 0.7 +3.5 3451 0.2 ELF3 CTCF PKNOX1 ZNF792 ARID4B MAX SIN3A RAD21 TEAD3 ZNF143 HPX APBB1
GH11J006438 Enhancer 0.4 ENCODE 0.7 +4.4 4431 0.2 MITF MAX SPI1 HPX APBB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HPX gene promoter:
  • c-Jun
  • ATF-2
  • GATA-2
  • p300
  • C/EBPalpha
  • CHOP-10
  • E2F
  • E2F-1

Genomic Locations for HPX Gene

Genomic Locations for HPX Gene
chr11:6,431,038-6,442,617
(GRCh38/hg38)
Size:
11,580 bases
Orientation:
Minus strand
chr11:6,452,268-6,463,847
(GRCh37/hg19)
Size:
11,580 bases
Orientation:
Minus strand

Genomic View for HPX Gene

Genes around HPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPX Gene

Proteins for HPX Gene

  • Protein details for HPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02790-HEMO_HUMAN
    Recommended name:
    Hemopexin
    Protein Accession:
    P02790
    Secondary Accessions:
    • B2R957

    Protein attributes for HPX Gene

    Size:
    462 amino acids
    Molecular mass:
    51676 Da
    Quaternary structure:
    • Interacts with HEV ORF3 protein. Interacts with FLVCR1.
    Miscellaneous:
    • The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).
    SequenceCaution:
    • Sequence=CAA26382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HPX Gene

Post-translational modifications for HPX Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.
  • Glycosylation at Asn453, isoforms=246, isoforms=240, Asn187, isoforms=64, Thr29, and isoforms=24
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HEMO_HUMAN (757)

Other Protein References for HPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPX Gene

Domains & Families for HPX Gene

Gene Families for HPX Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for HPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02790

UniProtKB/Swiss-Prot:

HEMO_HUMAN :
  • Belongs to the hemopexin family.
Family:
  • Belongs to the hemopexin family.
genes like me logo Genes that share domains with HPX: view

Function for HPX Gene

Molecular function for HPX Gene

UniProtKB/Swiss-Prot Function:
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
GENATLAS Biochemistry:
hemopexin,beta 1 glycoprotein of blood serum

Gene Ontology (GO) - Molecular Function for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20610401
GO:0015232 heme transporter activity IEA,TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HPX: view
genes like me logo Genes that share phenotypes with HPX: view

Animal Models for HPX Gene

MGI Knock Outs for HPX:
  • Hpx Hpx<tm1Altr>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HPX Gene

Localization for HPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPX Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPX gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 19433579
GO:0070062 extracellular exosome HDA 19056867
GO:0071682 endocytic vesicle lumen TAS --
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with HPX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HPX Gene

Pathways & Interactions for HPX Gene

genes like me logo Genes that share pathways with HPX: view

Gene Ontology (GO) - Biological Process for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0006879 cellular iron ion homeostasis TAS,IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0015886 heme transport TAS,IEA --
genes like me logo Genes that share ontologies with HPX: view

No data available for SIGNOR curated interactions for HPX Gene

Drugs & Compounds for HPX Gene

(17) Drugs for HPX Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(16) Additional Compounds for HPX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
15438-31-0
genes like me logo Genes that share compounds with HPX: view

Transcripts for HPX Gene

mRNA/cDNA for HPX Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(287) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPX Gene

Hemopexin:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for HPX Gene

GeneLoc Exon Structure for
HPX
ECgene alternative splicing isoforms for
HPX

Expression for HPX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPX Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for HPX Gene

This gene is overexpressed in Synovial fluid (21.2), Plasma (10.4), and Serum (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HPX Gene



Protein tissue co-expression partners for HPX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HPX Gene:

HPX

SOURCE GeneReport for Unigene cluster for HPX Gene:

Hs.426485

mRNA Expression by UniProt/SwissProt for HPX Gene:

P02790-HEMO_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for HPX Gene

  • Liver(5)
  • Nervous system(4.4)
  • Saliva(4.2)
  • Bone marrow(4.1)
  • Blood(2.8)
  • Kidney(2.5)
  • Lung(2.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with HPX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HPX Gene

Orthologs for HPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPX 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HPX 34 33
  • 85.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hpx 33
  • 82.57 (n)
mouse
(Mus musculus)
Mammalia Hpx 16 34 33
  • 81.84 (n)
cow
(Bos Taurus)
Mammalia HPX 34 33
  • 81.05 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HPX 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HPX 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves HPX 34 33
  • 57.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPX 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495728 33
  • 54.95 (n)
zebrafish
(Danio rerio)
Actinopterygii hpx 34 33
  • 50.65 (n)
OneToMany
HPX (2 of 2) 34
  • 38 (a)
OneToMany
Species where no ortholog for HPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPX Gene

ENSEMBL:
Gene Tree for HPX (if available)
TreeFam:
Gene Tree for HPX (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPX: view image

Paralogs for HPX Gene

No data available for Paralogs for HPX Gene

Variants for HPX Gene

Sequence variations from dbSNP and Humsavar for HPX Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000336543 -- 6,435,231(-) C/A/T intron_variant
rs1000383822 -- 6,435,105(-) A/G/T intron_variant
rs1000397560 -- 6,441,118(-) G/T upstream_transcript_variant
rs1000887153 -- 6,430,646(-) T/C downstream_transcript_variant
rs1000955089 -- 6,436,742(-) G/A intron_variant

Variation tolerance for HPX Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HPX Gene

Disorders for HPX Gene

MalaCards: The human disease database

(4) MalaCards diseases for HPX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
blackwater fever
  • black water fever
testicular yolk sac tumor
  • yolk sac tumor
pediatric multiple sclerosis
  • ms pediatric
atransferrinemia
  • hypotransferrinemia, familial
- elite association - COSMIC cancer census association via MalaCards
Search HPX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HPX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPX Gene

Publications for HPX Gene

  1. Structure of the human hemopexin gene and evidence for intron-mediated evolution. (PMID: 2842511) Altruda F … Silengo L (Journal of molecular evolution 1988) 2 3 4 58
  2. The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. (PMID: 2989777) Altruda F … Silengo L (Nucleic acids research 1985) 2 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. (PMID: 20610401) Yang Z … Abkowitz JL (The Journal of biological chemistry 2010) 3 4 58
  5. The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II. (PMID: 18211098) Ratra R … Lal SK (Biochemistry 2008) 4 22 58

Products for HPX Gene

  • Boster Bio Antibodies for HPX
  • Boster Bio ELISA Kits for HPX

Sources for HPX Gene

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