Aliases for SIRT3 Gene
- Sirtuin 3 2 3 5
- Regulatory Protein SIR2 Homolog 3 3 4
- SIR2-Like Protein 3 3 4
- SIR2L3 3 4
- Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae) 2
- Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3 2
- Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase 3
- Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3 3
External Ids for SIRT3 Gene
Previous GeneCards Identifiers for SIRT3 Gene
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIRT3 Gene
SIRT3 (Sirtuin 3) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Central carbon metabolism in cancer. Gene Ontology (GO) annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is SIRT2.
UniProtKB/Swiss-Prot for SIRT3 Gene
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.