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Aliases for SLC25A5 Gene

Aliases for SLC25A5 Gene

  • Solute Carrier Family 25 Member 5 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 2 3
  • ADP,ATP Carrier Protein, Fibroblast Isoform 3 4
  • ANT2 3 4
  • Adenine Nucleotide Translocator 2 (Fibroblast) 3
  • Adenine Nucleotide Translocator 2 4
  • ADP,ATP Carrier Protein 2 4
  • ADP/ATP Translocase 2 3
  • ANT 2 4
  • AAC2 3
  • 2F1 3
  • T2 3
  • T3 3

External Ids for SLC25A5 Gene

Previous HGNC Symbols for SLC25A5 Gene

  • ANT2

Previous GeneCards Identifiers for SLC25A5 Gene

  • GC0XP113420
  • GC0XP115588
  • GC0XP116577
  • GC0XP117356
  • GC0XP118384
  • GC0XP118486
  • GC0XP118602
  • GC0XP108095

Summaries for SLC25A5 Gene

Entrez Gene Summary for SLC25A5 Gene

  • This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

GeneCards Summary for SLC25A5 Gene

SLC25A5 (Solute Carrier Family 25 Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include Oncocytoma and Non-Syndromic Intellectual Disability. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A6.

UniProtKB/Swiss-Prot for SLC25A5 Gene

  • Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Additional gene information for SLC25A5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A5 Gene

Genomics for SLC25A5 Gene

GeneHancer (GH) Regulatory Elements for SLC25A5 Gene

Promoters and enhancers for SLC25A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119466 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 657.9 +0.8 809 4.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 SP3 SLC25A5-AS1 SLC25A5 PIR58034 SLC25A43 CXorf56 NKAPP1 UPF3B RNU1-67P ENSG00000237903 EEF1A1P30
GH0XJ119493 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.1 +27.1 27098 4.3 FOXA2 DMAP1 ZNF48 RARA CEBPA KDM1A HNF4A MYC FOXP1 ZBTB17 SLC25A43 CXorf56 SLC25A5 SLC25A5-AS1 ENSG00000226661 GC0XM119476 GC0XM119539
GH0XJ119512 Enhancer 1 Ensembl ENCODE dbSUPER 12.7 +44.1 44092 0.6 CTCF ZNF654 RB1 ARID4B REST ZNF384 RAD21 SP1 ZNF121 BCL6B CXorf56 SLC25A43 SLC25A5 SLC25A5-AS1 RNU1-67P ENSG00000237903 ENSG00000226661 GC0XM119539 GC0XM119476
GH0XJ119674 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 +216.3 216304 20.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B FEZF1 IRF4 YY1 POLR2B SEPT6 NKAPP1 EEF1A1P30 CUL4B NKAP NKRF UPF3B MIR766 CXorf56 SLC25A5-AS1
GH0XJ119564 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.3 +96.8 96824 1.6 CLOCK ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 SP3 NFYC CXorf56 SLC25A5 GC0XM119539
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC25A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A5 gene promoter:
  • AP-1
  • PPAR-alpha
  • STAT3
  • MyoD
  • c-Jun
  • ATF-2

Genomic Locations for SLC25A5 Gene

Genomic Locations for SLC25A5 Gene
chrX:119,468,400-119,471,396
(GRCh38/hg38)
Size:
2,997 bases
Orientation:
Plus strand
chrX:118,602,363-118,605,359
(GRCh37/hg19)
Size:
2,997 bases
Orientation:
Plus strand

Genomic View for SLC25A5 Gene

Genes around SLC25A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A5 Gene

Proteins for SLC25A5 Gene

  • Protein details for SLC25A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05141-ADT2_HUMAN
    Recommended name:
    ADP/ATP translocase 2
    Protein Accession:
    P05141
    Secondary Accessions:
    • B2RCV1
    • O43350

    Protein attributes for SLC25A5 Gene

    Size:
    298 amino acids
    Molecular mass:
    32852 Da
    Quaternary structure:
    • Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr.

neXtProt entry for SLC25A5 Gene

Post-translational modifications for SLC25A5 Gene

  • Ubiquitination at posLast=245245, posLast=166166, isoforms=105, and posLast=4343
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A5 Gene

Domains & Families for SLC25A5 Gene

Gene Families for SLC25A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC25A5 Gene

Graphical View of Domain Structure for InterPro Entry

P05141

UniProtKB/Swiss-Prot:

ADT2_HUMAN :
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Domain:
  • The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A5: view

Function for SLC25A5 Gene

Molecular function for SLC25A5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Gene Ontology (GO) - Molecular Function for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005471 ATP:ADP antiporter activity IBA --
GO:0005515 protein binding IPI 17715127
GO:0015207 adenine transmembrane transporter activity TAS --
GO:0022857 transmembrane transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A5: view
genes like me logo Genes that share phenotypes with SLC25A5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A5 Gene

Localization for SLC25A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A5 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IDA,IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2168878
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with SLC25A5: view

Pathways & Interactions for SLC25A5 Gene

genes like me logo Genes that share pathways with SLC25A5: view

Pathways by source for SLC25A5 Gene

1 GeneGo (Thomson Reuters) pathway for SLC25A5 Gene
2 Qiagen pathways for SLC25A5 Gene
1 Cell Signaling Technology pathway for SLC25A5 Gene

Gene Ontology (GO) - Biological Process for SLC25A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006839 mitochondrial transport IBA --
GO:0007059 chromosome segregation IEA --
GO:0008284 positive regulation of cell proliferation IMP 19154410
GO:0015853 adenine transport IEA --
GO:0015866 ADP transport IEA --
genes like me logo Genes that share ontologies with SLC25A5: view

No data available for SIGNOR curated interactions for SLC25A5 Gene

Drugs & Compounds for SLC25A5 Gene

(6) Drugs for SLC25A5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clodronate Approved, Investigational, Vet_approved Pharma inhibitor, Target 10
Atractyloside Dipotassium Salt Pharma ANT inhibitor 0

(1) Additional Compounds for SLC25A5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A5: view

Transcripts for SLC25A5 Gene

mRNA/cDNA for SLC25A5 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1324) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A5 Gene

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A5 Gene

No ASD Table

Relevant External Links for SLC25A5 Gene

GeneLoc Exon Structure for
SLC25A5
ECgene alternative splicing isoforms for
SLC25A5

Expression for SLC25A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A5 Gene

This gene is overexpressed in Nasal epithelium (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A5 Gene



Protein tissue co-expression partners for SLC25A5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A5 Gene:

SLC25A5

SOURCE GeneReport for Unigene cluster for SLC25A5 Gene:

Hs.632282

Evidence on tissue expression from TISSUES for SLC25A5 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Liver(4.6)
  • Skin(4.3)
  • Blood(4.2)
  • Lung(4.1)
  • Pancreas(3.7)
  • Intestine(3.6)
  • Kidney(3.6)
  • Muscle(2.6)
  • Stomach(2.6)
  • Heart(2.5)
  • Thyroid gland(2.4)
  • Lymph node(2.2)
  • Bone marrow(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SLC25A5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A5 Gene

Orthologs for SLC25A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A5 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A5 34 33
  • 94.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A5 34 33
  • 93.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a5 33
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Slc25a5 16 34 33
  • 92.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC25A6 34
  • 88 (a)
OneToOne
SLC25A5 33
  • 81.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 91 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75700 33
  • 80.81 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC25A5 (1 of 2) 34
  • 84 (a)
OneToMany
slc25a5 34 33
  • 81.98 (n)
OneToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta sesB 34 35
  • 77 (a)
ManyToMany
Ant2 34 35
  • 71 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T01B11.4 35
  • 71 (a)
K01H12.2 35
  • 71 (a)
ant-1.1 34
  • 68 (a)
ManyToMany
ant-1.3 34
  • 67 (a)
ManyToMany
W02D3.6 35
  • 67 (a)
C47E12.2 34 35
  • 49 (a)
ManyToMany
F25B4.7 34 35
  • 47 (a)
ManyToMany
R07E3.4 35
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAC3 34
  • 52 (a)
ManyToMany
AAC1 34
  • 50 (a)
ManyToMany
PET9 34
  • 50 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.23386 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2354 34
  • 53 (a)
ManyToMany
Species where no ortholog for SLC25A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A5 Gene

ENSEMBL:
Gene Tree for SLC25A5 (if available)
TreeFam:
Gene Tree for SLC25A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC25A5: view image

Paralogs for SLC25A5 Gene

Paralogs for SLC25A5 Gene

(5) SIMAP similar genes for SLC25A5 Gene using alignment to 2 proteins:

  • ADT2_HUMAN
  • Q6NVC0_HUMAN
genes like me logo Genes that share paralogs with SLC25A5: view

Variants for SLC25A5 Gene

Sequence variations from dbSNP and Humsavar for SLC25A5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs115513989 uncertain-significance, not specified 119,470,436(+) C/G coding_sequence_variant, missense_variant
rs73213195 benign, not specified 119,471,038(+) G/T coding_sequence_variant, stop_gained
rs77294853 benign, not specified 119,471,054(+) C/T coding_sequence_variant, missense_variant
rs80323990 benign, not specified 119,471,049(+) G/C coding_sequence_variant, missense_variant
rs1001107452 -- 119,471,471(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A5 Gene

Variant ID Type Subtype PubMed ID
esv2740427 CNV deletion 23290073
esv2740429 CNV deletion 23290073

Variation tolerance for SLC25A5 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A5 Gene

Human Gene Mutation Database (HGMD)
SLC25A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A5 Gene

Disorders for SLC25A5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC25A5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oncocytoma
  • oxyphilic adenoma
non-syndromic intellectual disability
  • intellectual disability, non syndromic
male reproductive organ benign neoplasm
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A5

genes like me logo Genes that share disorders with SLC25A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A5 Gene

Publications for SLC25A5 Gene

  1. Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches. (PMID: 8918809) Chen CN … Chen E (Nucleic acids research 1996) 3 4 22 58
  2. The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence. (PMID: 2168878) Ku DH … Wurzel J (The Journal of biological chemistry 1990) 2 3 4 58
  3. Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. (PMID: 2829183) Houldsworth J … Attardi G (Proceedings of the National Academy of Sciences of the United States of America 1988) 2 3 4 58
  4. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. (PMID: 20797633) Ito S … Tanaka K (Molecular cell 2010) 3 4 58
  5. Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis. (PMID: 19154410) Kashiwaya K … Nakagawa H (Cancer science 2009) 3 22 58

Products for SLC25A5 Gene

Sources for SLC25A5 Gene

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