Aliases for SLC25A5 Gene
- Solute Carrier Family 25 Member 5 2 3 4 5
- Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 2 3
- ADP,ATP Carrier Protein, Fibroblast Isoform 3 4
- ANT2 3 4
- Adenine Nucleotide Translocator 2 (Fibroblast) 3
- Adenine Nucleotide Translocator 2 4
- ADP,ATP Carrier Protein 2 4
External Ids for SLC25A5 Gene
Previous HGNC Symbols for SLC25A5 Gene
Previous GeneCards Identifiers for SLC25A5 Gene
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
GeneCards Summary for SLC25A5 Gene
SLC25A5 (Solute Carrier Family 25 Member 5) is a Protein Coding gene. Diseases associated with SLC25A5 include Oncocytoma and Non-Syndromic Intellectual Disability. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include adenine transmembrane transporter activity. An important paralog of this gene is SLC25A6.
UniProtKB/Swiss-Prot for SLC25A5 Gene
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.