Aliases for ZBTB14 Gene

Aliases for ZBTB14 Gene

  • Zinc Finger And BTB Domain Containing 14 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 14 3 4
  • Zinc Finger Protein 161 Homolog 3 4
  • Zinc Finger Protein 5 Homolog 3 4
  • ZFP161 Zinc Finger Protein 2 3
  • Zinc Finger Protein 478 3 4
  • ZFP161 3 4
  • ZNF478 3 4
  • ZF5 3 4
  • Zinc Finger Protein Homologous To Zfp161 In Mouse 3
  • Zinc Finger Protein 161 Homolog (Mouse) 2
  • Zinc Finger Protein 161 2
  • ZFP-161 3
  • Zfp-161 4
  • ZFP-5 3
  • Zfp-5 4
  • HZF5 4

External Ids for ZBTB14 Gene

Previous HGNC Symbols for ZBTB14 Gene

  • ZFP161

Summaries for ZBTB14 Gene

GeneCards Summary for ZBTB14 Gene

ZBTB14 (Zinc Finger And BTB Domain Containing 14) is a Protein Coding gene. Diseases associated with ZBTB14 include Hermansky-Pudlak Syndrome and Myopia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZBTB49.

UniProtKB/Swiss-Prot Summary for ZBTB14 Gene

  • Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.

Gene Wiki entry for ZBTB14 Gene

Additional gene information for ZBTB14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZBTB14 Gene

Genomics for ZBTB14 Gene

GeneHancer (GH) Regulatory Elements for ZBTB14 Gene

Promoters and enhancers for ZBTB14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J005293 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 506.1 +0.6 579 5.8 EP300 FOXK2 NRF1 POLR2G SP1 NCOR1 GTF2E2 PHF8 POLR2A KDM6A ZBTB14 lnc-ARHGAP28-18 LINC00667 AKAIN1 lnc-AKAIN1-4
GH18J005318 Enhancer 0.2 FANTOM5 2.8 -21.6 -21575 0.3 AKAIN1 ZBTB14 ENSG00000264254 piR-39858-290
GH18J005309 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -13.3 -13250 1.2 TBX21 CEBPG CEBPB POLR2A RUNX3 ENSG00000264254 ZBTB14
GH18J005766 Enhancer 0.2 FANTOM5 1.8 -469.8 -469794 0.1 ZBTB14 piR-38051-132 MIR3976HG
GH18J005294 Promoter/Enhancer 0.5 Ensembl dbSUPER 0.7 +3.8 3752 0.2 lnc-AKAIN1-4 ZBTB14 piR-31534-298
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZBTB14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZBTB14

Genomic Locations for ZBTB14 Gene

Genomic Locations for ZBTB14 Gene
chr18:5,289,019-5,297,053
(GRCh38/hg38)
Size:
8,035 bases
Orientation:
Minus strand
chr18:5,289,018-5,297,052
(GRCh37/hg19)
Size:
8,035 bases
Orientation:
Minus strand

Genomic View for ZBTB14 Gene

Genes around ZBTB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB14 Gene

Proteins for ZBTB14 Gene

  • Protein details for ZBTB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43829-ZBT14_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 14
    Protein Accession:
    O43829
    Secondary Accessions:
    • O00403
    • Q2TB80

    Protein attributes for ZBTB14 Gene

    Size:
    449 amino acids
    Molecular mass:
    50956 Da
    Quaternary structure:
    • Interacts with ZBTB21.

neXtProt entry for ZBTB14 Gene

Post-translational modifications for ZBTB14 Gene

  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB14 Gene

Domains & Families for ZBTB14 Gene

Gene Families for ZBTB14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB14 Gene

Blocks:
  • BTB/POZ domain
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBTB14 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 5 homolog (ZF161_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43829

UniProtKB/Swiss-Prot:

ZBT14_HUMAN :
  • The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZBTB14: view

Function for ZBTB14 Gene

Molecular function for ZBTB14 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.

Phenotypes From GWAS Catalog for ZBTB14 Gene

Gene Ontology (GO) - Molecular Function for ZBTB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZBTB14: view
genes like me logo Genes that share phenotypes with ZBTB14: view

Animal Model Products

CRISPR Products

miRNA for ZBTB14 Gene

miRTarBase miRNAs that target ZBTB14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB14 Gene

Localization for ZBTB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB14 Gene

Nucleus. Note=Colocalizes with ZBTB21 in nucleus in HEK293 cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB14 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZBTB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 17714511
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with ZBTB14: view

Pathways & Interactions for ZBTB14 Gene

PathCards logo

SuperPathways for ZBTB14 Gene

No Data Available

SIGNOR curated interactions for ZBTB14 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for ZBTB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0003170 heart valve development IEA --
GO:0003279 cardiac septum development IEA --
GO:0045892 negative regulation of transcription, DNA-templated IMP 17714511
GO:0060976 coronary vasculature development IEA --
genes like me logo Genes that share ontologies with ZBTB14: view

No data available for Pathways by source for ZBTB14 Gene

Drugs & Compounds for ZBTB14 Gene

(1) Drugs for ZBTB14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZBTB14: view

Transcripts for ZBTB14 Gene

mRNA/cDNA for ZBTB14 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZBTB14

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB14 Gene

No ASD Table

Relevant External Links for ZBTB14 Gene

GeneLoc Exon Structure for
ZBTB14

Expression for ZBTB14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB14 Gene

Protein differential expression in normal tissues from HIPED for ZBTB14 Gene

This gene is overexpressed in Heart (26.6), Pancreas (22.6), and Peripheral blood mononuclear cells (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBTB14 Gene



Protein tissue co-expression partners for ZBTB14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZBTB14

SOURCE GeneReport for Unigene cluster for ZBTB14 Gene:

Hs.592340
genes like me logo Genes that share expression patterns with ZBTB14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB14 Gene

Orthologs for ZBTB14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB14 31
  • 100 (a)
OneToOne
ZFP161 30
  • 98.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB14 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB14 31 30
  • 92.58 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB14 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb14 17 31 30
  • 87.6 (n)
rat
(Rattus norvegicus)
Mammalia Zfp161 30
  • 87.16 (n)
cow
(Bos Taurus)
Mammalia ZBTB14 31 30
  • 85.6 (n)
OneToOne
chicken
(Gallus gallus)
Aves ZFP161 31 30
  • 82.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB14 31
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb14 30
  • 77.4 (n)
Str.19698 30
zebrafish
(Danio rerio)
Actinopterygii zbtb14 31 30
  • 70.55 (n)
OneToOne
wufd57e03 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12466 30
Species where no ortholog for ZBTB14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB14 Gene

ENSEMBL:
Gene Tree for ZBTB14 (if available)
TreeFam:
Gene Tree for ZBTB14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZBTB14: view image

Paralogs for ZBTB14 Gene

(46) SIMAP similar genes for ZBTB14 Gene using alignment to 4 proteins:

  • ZBT14_HUMAN
  • J3KRQ2_HUMAN
  • J3QL74_HUMAN
  • J3QLI2_HUMAN

Pseudogenes.org Pseudogenes for ZBTB14 Gene

genes like me logo Genes that share paralogs with ZBTB14: view

Variants for ZBTB14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZBTB14 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs7235420 - p.Gln139Arg
rs7235740 - p.Glu77Gly

Additional dbSNP identifiers (rs#s) for ZBTB14 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB14 Gene

Variant ID Type Subtype PubMed ID
dgv184n21 CNV gain 19592680
dgv5825n54 CNV loss 21841781
dgv5826n54 CNV gain 21841781
dgv5827n54 CNV gain+loss 21841781
dgv5828n54 CNV gain+loss 21841781
dgv5829n54 CNV gain 21841781
dgv5830n54 CNV loss 21841781
esv23795 CNV loss 19812545
nsv1060440 CNV gain 25217958
nsv1136247 CNV deletion 24896259
nsv2195 CNV deletion 18451855
nsv511601 CNV gain 21212237
nsv576338 CNV loss 21841781
nsv576349 CNV gain+loss 21841781
nsv576351 CNV loss 21841781
nsv576352 CNV gain 21841781
nsv576357 CNV loss 21841781
nsv576362 CNV gain 21841781
nsv576364 CNV loss 21841781
nsv7301 OTHER inversion 18451855
nsv952405 CNV deletion 24416366

Variation tolerance for ZBTB14 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZBTB14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB14 Gene

Disorders for ZBTB14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZBTB14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hermansky-pudlak syndrome
  • albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZBTB14

genes like me logo Genes that share disorders with ZBTB14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB14 Gene

Publications for ZBTB14 Gene

No publications were found for ZBTB14 Gene.

Products for ZBTB14 Gene

Sources for ZBTB14 Gene