This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript... See more...

Aliases for HSP90AB1 Gene

Aliases for HSP90AB1 Gene

  • Heat Shock Protein 90 Alpha Family Class B Member 1 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1 2 3
  • Heat Shock 90kD Protein 1, Beta 2 3
  • Heat Shock Protein HSP 90-Beta 3 4
  • Heat Shock 84 KDa 3 4
  • HSP90B 3 4
  • HSPC2 3 4
  • HSPCB 3 4
  • HSP84 3 4
  • Heat Shock Protein 90kDa Alpha Family Class B Member 1 3
  • Heat Shock 90kDa Protein 1, Beta 2
  • Heat Shock Protein 90 KDa 3
  • HSP90-Beta 3
  • D6S182 3
  • HSP 84 4
  • HSP 90 4

External Ids for HSP90AB1 Gene

Previous HGNC Symbols for HSP90AB1 Gene

  • HSPC2
  • HSPCB

Previous GeneCards Identifiers for HSP90AB1 Gene

  • GC06P044323
  • GC06P044324
  • GC06P044214
  • GC06P043936

Summaries for HSP90AB1 Gene

Entrez Gene Summary for HSP90AB1 Gene

  • This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

GeneCards Summary for HSP90AB1 Gene

HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and NOD-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is HSP90AA1.

UniProtKB/Swiss-Prot Summary for HSP90AB1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823).

Tocris Summary for HSP90AB1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Gene Wiki entry for HSP90AB1 Gene

Additional gene information for HSP90AB1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSP90AB1 Gene

Genomics for HSP90AB1 Gene

GeneHancer (GH) Regulatory Elements for HSP90AB1 Gene

Promoters and enhancers for HSP90AB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSP90AB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSP90AB1 gene promoter:
  • CP2
  • Egr-4
  • Elk-1
  • Lmo2
  • MZF-1
  • NF-1
  • p300
  • Sp1
  • YY1

Genomic Locations for HSP90AB1 Gene

Genomic Locations for HSP90AB1 Gene
chr6:44,246,166-44,253,888
(GRCh38/hg38)
Size:
7,723 bases
Orientation:
Plus strand
chr6:44,214,824-44,221,620
(GRCh37/hg19)
Size:
6,797 bases
Orientation:
Plus strand

Genomic View for HSP90AB1 Gene

Genes around HSP90AB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AB1 Gene

Proteins for HSP90AB1 Gene

  • Protein details for HSP90AB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08238-HS90B_HUMAN
    Recommended name:
    Heat shock protein HSP 90-beta
    Protein Accession:
    P08238
    Secondary Accessions:
    • B2R5P0
    • Q5T9W7
    • Q9NQW0
    • Q9NTK6

    Protein attributes for HSP90AB1 Gene

    Size:
    724 amino acids
    Molecular mass:
    83264 Da
    Quaternary structure:
    • Monomer (PubMed:24880080). Homodimer (PubMed:7588731, PubMed:18400751). Forms a complex with CDK6 and CDC37 (PubMed:9482106, PubMed:25486457). Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (PubMed:16478993). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7 (PubMed:18620420). Interacts with FKBP4 (PubMed:15159550). May interact with NWD1 (PubMed:24681825). Interacts with SGTA (PubMed:16580629). Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with XPO1 and AHSA1 (PubMed:22022502, PubMed:25486457). Interacts with BIRC2 (PubMed:25486457). Interacts with KCNQ4; promotes cell surface expression of KCNQ4 (PubMed:23431407). Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2 (PubMed:18239673). Interacts with NOS3 (PubMed:23585225). Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255 (PubMed:15581363). Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation (PubMed:24880080). Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner (PubMed:20353823). Interacts with HSP90AA1; interaction is constitutive (PubMed:20353823). HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation (PubMed:23428871). Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression (PubMed:22843495). Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation (PubMed:15358771). Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (PubMed:20599762). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity).
    SequenceCaution:
    • Sequence=AAD14062.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66478.1; Type=Frameshift; Positions=709; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSP90AB1 Gene

neXtProt entry for HSP90AB1 Gene

Post-translational modifications for HSP90AB1 Gene

  • Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
  • ISGylated.
  • S-nitrosylated; negatively regulates the ATPase activity.
  • Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide (PubMed:23585225). Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction (PubMed:15581363).
  • Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
  • Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
  • Glycosylation at Asn46, Asn389, Ser434, and Ser452
  • Ubiquitination at Lys306, Lys411, Lys428, Lys435, Lys438, Lys481, Lys491, Lys505, and Lys624
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HS90B_HUMAN (1302)

Antibody Products

No data available for DME Specific Peptides for HSP90AB1 Gene

Domains & Families for HSP90AB1 Gene

Gene Families for HSP90AB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HSP90AB1 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock 84 kDa (HS90B_HUMAN)
  • Heat shock protein 90kDa alpha (Cytosolic), class B member 1 (Q5T9W4_HUMAN)
  • Heat shock protein 90kDa alpha (Cytosolic), class B member 1 (Q5T9W5_HUMAN)
  • Heat shock protein 90kDa alpha (Cytosolic), class B member 1 (Q5T9W6_HUMAN)
  • HSP90AB1 protein (Q6PK50_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08238

UniProtKB/Swiss-Prot:

HS90B_HUMAN :
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
  • Belongs to the heat shock protein 90 family.
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AB1: view

Function for HSP90AB1 Gene

Molecular function for HSP90AB1 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823).
UniProtKB/Swiss-Prot EnzymeRegulation:
In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for ATP {ECO:0000269 PubMed:18400751};
UniProtKB/Swiss-Prot Induction:
By heat shock.

Phenotypes From GWAS Catalog for HSP90AB1 Gene

Gene Ontology (GO) - Molecular Function for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002134 UTP binding IEA --
GO:0002135 CTP binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 11036079
genes like me logo Genes that share ontologies with HSP90AB1: view
genes like me logo Genes that share phenotypes with HSP90AB1: view

Animal Model Products

CRISPR Products

miRNA for HSP90AB1 Gene

miRTarBase miRNAs that target HSP90AB1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSP90AB1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSP90AB1 Gene

Localization for HSP90AB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AB1 Gene

Cytoplasm. Melanosome. Nucleus. Secreted. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). {ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:18239673, ECO:0000269 PubMed:20599762}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSP90AB1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
endoplasmic reticulum 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 18239673
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IBA 10791971
GO:0005739 mitochondrion HDA 20833797
genes like me logo Genes that share ontologies with HSP90AB1: view

Pathways & Interactions for HSP90AB1 Gene

genes like me logo Genes that share pathways with HSP90AB1: view

SIGNOR curated interactions for HSP90AB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEA --
GO:0006457 protein folding IBA 21873635
GO:0006805 xenobiotic metabolic process TAS --
GO:0006986 response to unfolded protein NAS 2768249
GO:0007004 telomere maintenance via telomerase IDA 10197982
genes like me logo Genes that share ontologies with HSP90AB1: view

Drugs & Compounds for HSP90AB1 Gene

(52) Drugs for HSP90AB1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2286
Geldanamycin Experimental, Investigational Pharma Target Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 10
Radicicol Experimental Pharma Target ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic 0
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE Experimental Pharma Target 0
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE Experimental Pharma Target 0

(7) Additional Compounds for HSP90AB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7
KRIBB11
342639-96-7

(4) Tocris Compounds for HSP90AB1 Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor 75747-14-7
Geldanamycin Selective Hsp90 inhibitor 30562-34-6
KRIBB11 HSF1 inhibitor 342639-96-7
Radicicol Hsp90 inhibitor. Antifungal antibiotic 12772-57-5

(21) ApexBio Compounds for HSP90AB1 Gene

Compound Action Cas Number
17-AAG (KOS953) Hsp90 inhibitor 75747-14-7
17-DMAG (Alvespimycin) HCl Hsp90 inhibitor 467214-21-7
AT13387 Hsp90 inhibitor 912999-49-6
AUY922 (NVP-AUY922) Potent Hsp90 inhibitor 747412-49-3
BIIB021 Hsp90 inhibitor,selective and competitive 848695-25-0
CH5138303 959763-06-5
Ganetespib (STA-9090) Hsp90 inhibitor,non-geldanamycin 888216-25-9
Geldanamycin Hsp90 inhibitor,potent and specific 30562-34-6
HSP990 (NVP-HSP990) 934343-74-5
IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective 857402-63-2
KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, 819812-04-9
MPC-3100 Hsp90 inhibitor 958025-66-6
NMS-E973 Hsp90 inhibitor,potent and selective 1253584-84-7
NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic 847559-80-2
PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective 908115-27-5
PU-H71 Hsp90 inhibitor,potent and selective 873436-91-0
PU-WS13 Grp94-specific Hsp90 inhibitor 1454619-14-7
SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective 908112-43-6
VER-49009 558640-51-0
VER-50589 747413-08-7
XL-888 Hsp90 inhibitor 1149705-71-4
genes like me logo Genes that share compounds with HSP90AB1: view

Transcripts for HSP90AB1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSP90AB1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - -
SP10:
SP11: -
SP12:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSP90AB1 Gene

GeneLoc Exon Structure for
HSP90AB1
ECgene alternative splicing isoforms for
HSP90AB1

Expression for HSP90AB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSP90AB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSP90AB1 Gene

This gene is overexpressed in Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSP90AB1 Gene



Protein tissue co-expression partners for HSP90AB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSP90AB1 Gene:

HSP90AB1

SOURCE GeneReport for Unigene cluster for HSP90AB1 Gene:

Hs.509736

Evidence on tissue expression from TISSUES for HSP90AB1 Gene

  • Intestine(5)
  • Liver(5)
  • Skin(5)
  • Nervous system(5)
  • Blood(4.9)
  • Kidney(4.9)
  • Lung(4.9)
  • Muscle(4.9)
  • Pancreas(4.9)
  • Eye(4.8)
  • Spleen(4.2)
  • Heart(4.1)
  • Thyroid gland(3.8)
  • Stomach(3.6)
  • Adrenal gland(2.6)
  • Gall bladder(2.2)
  • Lymph node(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with HSP90AB1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AB1 Gene

Orthologs for HSP90AB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AB1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLC29A1 33
  • 100 (a)
OneToOne
HSP90AB1 32
  • 91.39 (n)
chimpanzee
(Pan troglodytes)
Mammalia HSP90AB1 33 32
  • 99.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSP90AB1 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSP90AB1 33 32
  • 90.84 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsp90ab1 32
  • 89.83 (n)
mouse
(Mus musculus)
Mammalia Hsp90ab1 17 33 32
  • 89.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90AB1 33
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSP90AB1 33 32
  • 81.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90AB1 33
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90ab1 32
  • 80.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29353 32
zebrafish
(Danio rerio)
Actinopterygii hsp90ab1 33 32
  • 79.89 (n)
OneToOne
-- 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1282 32
fruit fly
(Drosophila melanogaster)
Insecta Hsp83 33 32
  • 71.78 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta HSP83_ANOGA 32
  • 71.78 (n)
worm
(Caenorhabditis elegans)
Secernentea daf-21 33 32
  • 70.95 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL148C 32
  • 61.82 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12958g 32
  • 60.59 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP82 33 32
  • 60.53 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP90.1 32
  • 65.8 (n)
rice
(Oryza sativa)
Liliopsida Os08g0500700 32
  • 68.09 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.217 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11103 33
  • 78 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04142 32
  • 67.48 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hsp90 32
  • 62.7 (n)
Species where no ortholog for HSP90AB1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSP90AB1 Gene

ENSEMBL:
Gene Tree for HSP90AB1 (if available)
TreeFam:
Gene Tree for HSP90AB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSP90AB1: view image

Paralogs for HSP90AB1 Gene

Paralogs for HSP90AB1 Gene

(14) SIMAP similar genes for HSP90AB1 Gene using alignment to 3 proteins:

  • HS90B_HUMAN
  • Q5T9W8_HUMAN
  • Q6PK50_HUMAN
genes like me logo Genes that share paralogs with HSP90AB1: view

Variants for HSP90AB1 Gene

Sequence variations from dbSNP and Humsavar for HSP90AB1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000003153 -- 44,247,997(+) T/G 5_prime_UTR_variant, intron_variant
rs1000114763 -- 44,246,423(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000200257 -- 44,252,487(+) A/G intron_variant
rs1000491090 -- 44,247,757(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000530158 -- 44,247,353(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSP90AB1 Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv5282 CNV insertion 18451855
nsv603003 CNV gain 21841781
nsv969396 CNV duplication 23825009

Variation tolerance for HSP90AB1 Gene

Residual Variation Intolerance Score: 5.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSP90AB1 Gene

Human Gene Mutation Database (HGMD)
HSP90AB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90AB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AB1 Gene

Disorders for HSP90AB1 Gene

Additional Disease Information for HSP90AB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HSP90AB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSP90AB1 Gene

Publications for HSP90AB1 Gene

  1. Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. (PMID: 20353823) Cheng MB … Shen YF (Cellular signalling 2010) 3 4 23 56
  2. Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. (PMID: 18239673) Didelot C … Garrido C (Cell death and differentiation 2008) 3 4 23 56
  3. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B … Monteiro A (Genomics 2005) 2 3 23 56
  4. A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta). (PMID: 8180474) Takahashi I … Hashimoto K (Mammalian genome : official journal of the International Mammalian Genome Society 1994) 3 4 23 56
  5. Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (PMID: 2768249) Rebbe NF … Hickman S (The Journal of biological chemistry 1989) 2 3 4 56

Products for HSP90AB1 Gene