Aliases for GRM1 Gene
External Ids for GRM1 Gene
Previous GeneCards Identifiers for GRM1 Gene
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
GeneCards Summary for GRM1 Gene
GRM1 (Glutamate Metabotropic Receptor 1) is a Protein Coding gene. Diseases associated with GRM1 include Spinocerebellar Ataxia, Autosomal Recessive 13 and Spinocerebellar Ataxia 44. Among its related pathways are Transmission across Chemical Synapses and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM5.
UniProtKB/Swiss-Prot Summary for GRM1 Gene
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity).
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are divided into two subtypes, mGlu1 and mGlu5.