BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008] See more...

Aliases for BORA Gene

Aliases for BORA Gene

  • BORA Aurora Kinase A Activator 2 3 5
  • Protein Aurora Borealis 3 4
  • C13orf34 3 4
  • Chromosome 13 Open Reading Frame 34 2
  • Bora, Aurora Kinase A Activator 2
  • HsBora 4

External Ids for BORA Gene

Previous HGNC Symbols for BORA Gene

  • C13orf34

Previous GeneCards Identifiers for BORA Gene

  • GC13P073302

Summaries for BORA Gene

Entrez Gene Summary for BORA Gene

  • BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

GeneCards Summary for BORA Gene

BORA (BORA Aurora Kinase A Activator) is a Protein Coding gene. Diseases associated with BORA include Oculoglandular Tularemia and Branchiootic Syndrome. Among its related pathways are DNA Damage and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot Summary for BORA Gene

Additional gene information for BORA Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BORA Gene

Genomics for BORA Gene

GeneHancer (GH) Regulatory Elements for BORA Gene

Promoters and enhancers for BORA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J072726 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 511.6 +0.2 152 3.8 FOXK2 ZBTB40 SIN3A NRF1 POLR2G SP1 PHF8 FOS ZFX ZIC2 BORA MZT1 HSALNG0097884 PIBF1 DIS3
GH13J073039 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.8 +312.6 312552 4.2 TCF12 TCF7 EP300 ATF2 OSR2 FOXA2 TCF7L2 BRCA1 SIX5 NCOR1 BORA PIBF1 RF00017-1445 lnc-KLF5-4
GH13J072970 Enhancer 0.8 Ensembl ENCODE 13.1 +243.2 243244 1.8 ZNF510 ZNF266 FOS ZNF426 ZNF189 ZNF529 ZNF664 ZNF34 ZFP37 ZNF781 DIS3 PIBF1 BORA NONHSAG013753.2 lnc-DIS3-2
GH13J073029 Enhancer 0.3 Ensembl 5.6 +302.8 302751 1 PRDM1 RF00017-1444 BORA lnc-DIS3-3
GH13J072716 Enhancer 0.2 Ensembl 5.1 -10.7 -10748 0.8 MZT1 BORA KLF5 KR153194-046
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BORA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BORA

Genomic Locations for BORA Gene

Genomic Locations for BORA Gene
chr13:72,727,749-72,756,198
(GRCh38/hg38)
Size:
28,450 bases
Orientation:
Plus strand
chr13:73,302,042-73,330,336
(GRCh37/hg19)
Size:
28,295 bases
Orientation:
Plus strand

Genomic View for BORA Gene

Genes around BORA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORA Gene

Proteins for BORA Gene

  • Protein details for BORA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PGQ7-BORA_HUMAN
    Recommended name:
    Protein aurora borealis
    Protein Accession:
    Q6PGQ7
    Secondary Accessions:
    • B4DQ30
    • Q5W0P3
    • Q5W0P4
    • Q86YC6
    • Q96IW9
    • Q9H640

    Protein attributes for BORA Gene

    Size:
    559 amino acids
    Molecular mass:
    61203 Da
    Quaternary structure:
    • Interacts with AURKA.
    SequenceCaution:
    • Sequence=BAB15426.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for BORA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BORA Gene

Post-translational modifications for BORA Gene

No data available for DME Specific Peptides for BORA Gene

Domains & Families for BORA Gene

Gene Families for BORA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BORA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BORA Gene

GenScript: Design optimal peptide antigens:
  • FLJ22624 protein, isoform CRA_a (B5LMG6_HUMAN)
  • Protein aurora borealis (BORA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PGQ7

UniProtKB/Swiss-Prot:

BORA_HUMAN :
  • Belongs to the BORA family.
Family:
  • Belongs to the BORA family.
genes like me logo Genes that share domains with BORA: view

Function for BORA Gene

Molecular function for BORA Gene

UniProtKB/Swiss-Prot Function:
Required for the activation of AURKA at the onset of mitosis.

Gene Ontology (GO) - Molecular Function for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18521620
GO:0019901 protein kinase binding IBA,IPI 18521620
genes like me logo Genes that share ontologies with BORA: view
genes like me logo Genes that share phenotypes with BORA: view

Animal Model Products

CRISPR Products

miRNA for BORA Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BORA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BORA Gene

Localization for BORA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BORA gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0072687 colocalizes_with meiotic spindle IEA,IBA 21873635
genes like me logo Genes that share ontologies with BORA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BORA Gene

Pathways & Interactions for BORA Gene

genes like me logo Genes that share pathways with BORA: view

Pathways by source for BORA Gene

1 Cell Signaling Technology pathway for BORA Gene
1 GeneTex pathway for BORA Gene

SIGNOR curated interactions for BORA Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007088 regulation of mitotic nuclear division IMP,IBA 18521620
GO:0032147 activation of protein kinase activity IBA 21873635
GO:0032880 regulation of protein localization IMP 18521620
genes like me logo Genes that share ontologies with BORA: view

Drugs & Compounds for BORA Gene

No Compound Related Data Available

Transcripts for BORA Gene

mRNA/cDNA for BORA Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BORA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BORA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: - - -
SP4:

Relevant External Links for BORA Gene

GeneLoc Exon Structure for
BORA

Expression for BORA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BORA Gene

Protein differential expression in normal tissues from HIPED for BORA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BORA Gene



Protein tissue co-expression partners for BORA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BORA

SOURCE GeneReport for Unigene cluster for BORA Gene:

Hs.643464

Evidence on tissue expression from TISSUES for BORA Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with BORA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BORA Gene

Orthologs for BORA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BORA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BORA 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BORA 31 30
  • 90.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BORA 31 30
  • 87.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bora 30
  • 80.01 (n)
mouse
(Mus musculus)
Mammalia Bora 17 31 30
  • 77.59 (n)
oppossum
(Monodelphis domestica)
Mammalia BORA 31
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BORA 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves BORA 31 30
  • 68.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BORA 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bora 30
  • 62.1 (n)
zebrafish
(Danio rerio)
Actinopterygii bora 31 30
  • 53.09 (n)
OneToOne
Species where no ortholog for BORA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BORA Gene

ENSEMBL:
Gene Tree for BORA (if available)
TreeFam:
Gene Tree for BORA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BORA: view image

Paralogs for BORA Gene

(1) SIMAP similar genes for BORA Gene using alignment to 3 proteins:

  • BORA_HUMAN
  • B4DQ30_HUMAN
  • H3BLY2_HUMAN
genes like me logo Genes that share paralogs with BORA: view

No data available for Paralogs for BORA Gene

Variants for BORA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BORA Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs1146858 - p.Ser308Phe
rs9543107 - p.Ser210Leu

Additional dbSNP identifiers (rs#s) for BORA Gene

Structural Variations from Database of Genomic Variants (DGV) for BORA Gene

Variant ID Type Subtype PubMed ID
nsv1049859 CNV loss 25217958

Variation tolerance for BORA Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BORA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BORA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BORA Gene

Disorders for BORA Gene

MalaCards: The human disease database

(2) MalaCards diseases for BORA Gene - From: DISEASES

Disorder Aliases PubMed IDs
oculoglandular tularemia
branchiootic syndrome
  • branchiootic syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search BORA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BORA

genes like me logo Genes that share disorders with BORA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BORA Gene

Publications for BORA Gene

  1. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PMID: 16890155) Hutterer A … Knoblich JA (Developmental cell 2006) 2 3 4 54
  2. Aurora-A and hBora join the game of Polo. (PMID: 19487276) Macurek L … Medema RH (Cancer research 2009) 2 3 54
  3. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. (PMID: 18566290) Seki A … Fang G (Science (New York, N.Y.) 2008) 2 3 54
  4. Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. (PMID: 18378770) Seki A … Fang G (The Journal of cell biology 2008) 2 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for BORA Gene

Sources for BORA Gene