Aliases for ANXA4 Gene
External Ids for ANXA4 Gene
Previous HGNC Symbols for ANXA4 Gene
Previous GeneCards Identifiers for ANXA4 Gene
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
GeneCards Summary for ANXA4 Gene
ANXA4 (Annexin A4) is a Protein Coding gene. Diseases associated with ANXA4 include Papillary Serous Adenocarcinoma and Ovarian Clear Cell Adenocarcinoma. Among its related pathways are Prostaglandin Synthesis and Regulation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is ANXA5.
UniProtKB/Swiss-Prot Summary for ANXA4 Gene
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.