Aliases for ALG11 Gene
External Ids for ALG11 Gene
Previous GeneCards Identifiers for ALG11 Gene
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
GeneCards Summary for ALG11 Gene
ALG11 (ALG11 Alpha-1,2-Mannosyltransferase) is a Protein Coding gene. Diseases associated with ALG11 include Congenital Disorder Of Glycosylation, Type Ip and Congenital Disorders Of N-Linked Glycosylation And Multiple Pathway. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. An important paralog of this gene is ALG2.
UniProtKB/Swiss-Prot Summary for ALG11 Gene
Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.